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t cell PhD Projects, Programs & Scholarships

We have 100 t cell PhD Projects, Programs & Scholarships

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We have 100 t cell PhD Projects, Programs & Scholarships

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Function of CD8 T Cell communication during autoimmunity.

We are interested in understanding how cells of the adaptive immune system, called CD8 T cells, are recruited and organised in space and time in vivo in health and disease (1,2). Read more

Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity

The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more

How regulatory immunological cues (re)programme cellular metabolism to control effector T cell behaviour and function

Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more

B cell-T cell communication: the heart of the adaptive immune response

Talented and motivated students passionate about doing research are invited to apply for this PhD position. The successful applicant will join the Crick PhD Programme in September 2022 and will register for their PhD at one of the Crick partner universities (Imperial College London, King’s College London or UCL). Read more

Gene correlation network showing differences in gene expression of effector T cells derived from the bone marrow or peripheral tissues affected by GVHD.

Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more

Gene correlation network showing differences in gene expression of effector T cells derived from the bone marrow or peripheral tissues affected by GVHD.

Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more

Suppression of T cell immunity and antibody production during virus infection and sepsis

Summary. The generation of protective antibodies against infection is dependent on “help” from CD4+ T follicular helper (TFH) cells which are elicited in response to bacteria and viruses, such as influenza and SARS CoV-2. Read more

Elucidate the effects of chronic inflammation on CD8+T cell metabolism and exhaustion

Sustained inflammation causes immune cell dysfunction and forms the common pathological basis for many chronic inflammatory diseases including autoimmunity, chronic viral infection and cancer. Read more

Immune Modulation by ITIM Receptor Targeting

Commercial partner: . MiroBio. , Oxford. Signalling by inhibitory co-receptors, also termed immune checkpoint receptors, such as PD-1, reduces T cell function and promotes T cell exhaustion, compromising the immune response to pathogens and tumour cells. Read more

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