We have 97 t cell PhD Projects, Programmes & Scholarships

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t cell PhD Projects, Programmes & Scholarships

We have 97 t cell PhD Projects, Programmes & Scholarships

Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity

The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more

How regulatory immunological cues (re)programme cellular metabolism to control effector T cell behaviour and function

Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more
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Acquired somatic mutations drive ageing immune remodelling

Clonal haematopoiesis of indeterminate potential (CHIP) is a significant age-related risk factor for multiple conditions including hematologic cancers, cardiovascular disease, ischemic stroke and all-cause mortality.1 CHIP occurs when a hematopoietic stem cell (HSC) acquires an advantageous somatic mutation that results in increased self-renewal. Read more

Identifying causal pathways to disease using DNA methylation predicted blood traits.

Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more

MSc by Research: Using genome editing to study the mechanisms of immune cell proliferation and differentiation

T lymphocytes mediate long-term adaptive immunity to viruses and tumour cells. T lymphocytes recognize foreign antigens via specific interactions with the T cell receptor (TCR) that is expressed on the cell surface. Read more

Vaccine Engineering

An opportunity exists for a PhD position in vaccine engineering. Vaccines are one of the most effective health care interventions but remain a challenge for many diseases, and in particular intracellular pathogens such as malaria where T cell responses are particularly desirable. Read more

Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more

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