T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more
'TO APPLY, PLEASE CLICK INSTITUTION WEBSITE'. Project outline. It is becoming clear that the duration, frequency, and intensity of T cell/APC interactions, determines the induction of immunological tolerance versus priming. Read more
Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more
Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more
Tuberculosis (TB) is a worldwide disease characterized by dramatic differences in individual outcomes. Many infected with the etiological agent never see any signs of disease while others succumb to rapid fulminant infection in the lung. Read more
T lymphocytes mediate long-term adaptive immunity to viruses and tumour cells. T lymphocytes recognize foreign antigens via specific interactions with the T cell receptor (TCR) that is expressed on the cell surface. Read more
The main objective of the projects is to study the host-pathogen interaction of PRRSV-1 with the host immune system in pigs. While PRRSV-1 can be resolved by the host before the appearance of neutralising antibodies in blood, a role for the adaptive immune system is envisaged. Read more
This project is one of a number that are in competition for funding from the University of Bath URSA competition, for entry in September 2025. Read more
Overview. Immune checkpoint pathways determine the abilities of human malignant tumours to escape cytotoxic immune attack and thus progress the disease. Read more
Overview. Immune checkpoint pathways determine the abilities of human malignant tumours to escape cytotoxic immune attack and thus progress the disease. Read more
Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more
The adaptive immune system, especially T cells, plays a central role in cancer evolution. Reawakening the immune system with immunotherapy can be remarkably effective at treating cancer. Read more
Whether a cell dies or not has profound consequences on health and disease. In healthy tissue, cells that acquire high levels of genetic damage are safely removed via a process of programmed cell death. Read more
Background. Stem cells have an essential role in homeostasis, repair, and regeneration of a tissue or organ. The adult skin is home to largest collection of multipotent stem cells, which are immature cells with unlimited ability to self-renew and capacity to differentiate into different skin cell lineages. Read more
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