Adoptive cell therapy (ACT) using tumour infiltrating lymphocytes (TILs) or genetically redirected T cells are some of the most promising approaches to emerge recently for the treatment of metastatic disease. Read more
T cells play critical roles in the host response to viral infection. Activated cytotoxic CD8 T cells are able to kill virally infected cells while… Read more
The COVID-19 pandemic has seen unprecedented development and employment of new vaccine technologies that can be produced and administered quickly. Read more
SUMMARY. The induction and persistence of effective antigen(Ag)-specific memory T-cell responses is required to bestow long-term protection against infectious diseases, and hence is critical to vaccine development. Read more
Background. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in humans. There is a high unmet medical need to develop new therapies for the treatment of this disease. Read more
About the GW4 BioMed2 Doctoral Training Partnership. The partnership brings together the Universities of Bath, Bristol, Cardiff (lead) and Exeter to develop the next generation of biomedical researchers. Read more
The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more
Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more
Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 20 studentships for entry in September 2024. Read more
Cytotoxic T cells have the potential to effectively kill tumour target cells. However, in the tumour microenvironment this potential is substantially suppressed. Read more
Frozen shoulder is a disabling condition affecting 10% of the working population. Disease causes significant pain and immobility of the shoulder joint, reducing life quality of affected patients. Read more
Our laboratory aims to understand how mutation in tumour suppressors and oncogenes causes cancer. We focus on understanding the biochemical basis of oncogene and tumour suppressor activity in order to develop new cancer therapies. Read more
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