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t cells PhD Projects, Programmes & Scholarships
We have 59 t cells PhD Projects, Programmes & Scholarships
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Understanding the pro- and anti-tumour functions of IFNγ-producing γδ T cells
TO APPLY CLICK 'INSTITUTION WEBSITE' . γδ T cells are a rare population of T cell receptor-expressing cells that function like innate immune cells.γδ T cells consist of several different subtypes that can promote or prevent cancer progression, depending on the cytokines and cytotoxic molecules they express. Read more
Exploiting tumour-promoting paracrine signals in solid cancers to turbocharge genetically redirected T cells
Adoptive cell therapy (ACT) using tumour infiltrating lymphocytes (TILs) or genetically redirected T cells are some of the most promising approaches to emerge recently for the treatment of metastatic disease. Read more
Last chance to apply
Pilot study of an extended exercise intervention on senescent T cells and inflammatory markers in older adults ( Ref: WD_2022_17_WSCH)
Post summary. As we age, changes occur in the profile of the immune system T cells, resulting in less “young” T cells and more “older”, potential dysfunctional and inflammatory T cells. Read more
MSc by Research: Regulation of T cell function by SIK3 in viral infection
T cells play critical roles in the host response to viral infection. Activated cytotoxic CD8 T cells are able to kill virally infected cells while… Read more
Role of tumour directed T cells in smouldering myeloma
The UCL Myeloma and Tumour Immunology groups are seeking a talented and enthusiastic PhD candidate to lead a project to identify and characterise tumour directed T cells in the bone marrow environment of patients with smouldering myeloma. Smouldering myeloma is a pre-cancerous condition that carries a 50% risk (over 5 years) of developing into the bone marrow cancer called multiple myeloma. Read more
Gene correlation network showing differences in gene expression of effector T cells derived from the bone marrow or peripheral tissues affected by GVHD.
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
Gene correlation network showing differences in gene expression of effector T cells derived from the bone marrow or peripheral tissues affected by GVHD.
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
Treating Cancer with CAR-T Therapy and Single Cell Transcriptomics
Oxford Brookes University. Faculty of Health and Life Sciences. Department of Biological and Medical Sciences, with Coding Bio Ltd. Read more
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Investigation of an uncharacterised, embryonically lethal gene in immune cell development
This project is available through the MIBTP programme. The successful applicant will join the MIBTP cohort and will take part in all of the training offered by the programme. Read more
How regulatory immunological cues (re)programme cellular metabolism to control effector T cell behaviour and function
Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more
Single-Cell Lineage Mapping of Elite CAR-NK Cells
The advance of chimeric antigen receptor (CAR) technology has been a breakthrough in cancer immunotherapy. However, it is not clear in which subpopulation of immune cells the endowment of CAR will be most effective in treating cancer. Read more
Understanding tumour-mediated suppression of cytotoxic T cell function by rebuilding it in vitro
Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more
The role of the cross-talk between T cells and synovial fibroblasts in inflammatory osteoarthritis
Research interests/description of main research theme. Background. Mesenchymal stromal fibroblasts have emerged as key mediators of the inflammatory response and drivers of localised inflammation. Read more
PhD studentship in Determining the regulation of immune checkpoint co-receptors in an ageing immune system
Overview. The human Immune system is designed to protect against harmful pathogens but the function of the immune system deteriorates with age. Read more
Identifying the impact of genetic variants of MICB associated with severe and symptomatic dengue virus infection on NK and CD8+ T cell function
Supervisors. Dr Laura Rivino (Bristol, lead supervisor), Dr Edward Wang (Cardiff), Dr Richard Stanton (Cardiff), Prof Nicholas Timpson (Bristol), Dr Sophie Yacoub (Oxford University Clinical Research Unit, HCMC, Vietnam). Read more