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t cells PhD Projects, Programmes & Scholarships
We have 66 t cells PhD Projects, Programmes & Scholarships
The role of immunity in cardiovascular disease
The immune system is integral to the cardiovascular health and disease. Targeting inflammation ameliorates cardiovascular outcomes. Read more
Single-molecule and whole transcriptome studies of the dynamic in vivo mRNA structures in immunological memory
About the Project. The Babraham Institute is a world-leader in fundamental biological research investigating the systems that underpin development and healthy ageing. Read more
Discovery of novel modulators of T cell receptor signalling in cancer
Discovery of novel modulators of T cell receptor signalling in cancer. In cancer and chronic infection, chronically stimulated T cells reduce their function through mechanisms that are not fully understood. Read more
Mechanical force matters in T-cell activation
In the last 20 years there has been an emerging recognition that tumours modulate their mechanics to evade the human immune system (1). Read more
Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity
The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more
Exploring tumour microenvironmental influences on T cell anti-cancer functions
Academic Supervisor. Hayley Sharpe. Industrial Partner. Cancer Research Technology Limited trading as Cancer Research Horizons. Read more
Understanding the biology of Foxp3+ CD8+ regulatory T cells and their potential role in multiple sclerosis
CD4+Foxp3+ regulatory T-cells (Tregs) are the most well characterised suppressive cell type in the immune system, with potent roles in suppressing autoimmunity. Read more
Self-funded PhD- Understanding tumour-mediated suppression of cytotoxic T cell function by rebuilding it in vitro
Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more
Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)
Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more
The role of EBV in multiple sclerosis
About the research project. Epstein-Barr virus (EBV) is a double stranded DNA herpes virus that can have a profound effect on the immune system. Read more
Understanding how to target the T cell compartment within related brain tumours
T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more
Mapping CD4+ T cell fate decisions and functional coordination within tissues during infection
CD4+ T cells are essential components of the immune system, orchestrating protection against infection. Read more
Genetic Engineering of Immune Effector Cells for CAR therapies using a Peptide Technology
Chimeric antigen receptor (CAR)-T therapies have demonstrated remarkable treatment outcomes and several CAR-T therapies now approved for treatment of haematological malignancies. Read more
Multiomics to decipher T cell development in the thymus
Project Overview. Ongoing projects in the Teichmann team are generating scRNA-seq and chromatin accessibility profiles of thymic cells using the 10X multiome kit, combined with multiplex protein staining. Read more
Improving chemical and immunological assessment to drive safer development of the new breed of drugs: PROTACS
Proteolysis-targeting chimeras (PROTACs) are a new class of drugs with immense potential across multiple therapeutic areas in drug development. Read more