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t cells PhD Projects, Programmes & Scholarships
We have 57 t cells PhD Projects, Programmes & Scholarships
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Exploiting tumour-promoting paracrine signals in solid cancers to turbocharge genetically redirected T cells
Adoptive cell therapy (ACT) using tumour infiltrating lymphocytes (TILs) or genetically redirected T cells are some of the most promising approaches to emerge recently for the treatment of metastatic disease. Read more
MSc by Research: Regulation of T cell function by SIK3 in viral infection
T cells play critical roles in the host response to viral infection. Activated cytotoxic CD8 T cells are able to kill virally infected cells while… Read more
Developing Personalised Vaccines – the Next Generation in Vaccine Development (ref: SF22/HLS/APP/ANTONIOU)
The COVID-19 pandemic has seen unprecedented development and employment of new vaccine technologies that can be produced and administered quickly. Read more
PhD in Infection, Immunity, Antimicrobial Resistance & Repair - Clonal aging of anti-viral T cells impacts protective immunity
SUMMARY. The induction and persistence of effective antigen(Ag)-specific memory T-cell responses is required to bestow long-term protection against infectious diseases, and hence is critical to vaccine development. Read more
Understanding and exploiting antigen discrimination by T cells
T cells use their T-cell receptors (TCRs) to discriminate between lower-affinity self and higher affinity non-self pMHC antigens. Read more
Developing a pre-clinical human pancreatic cancer model to test novel immunotherapies.
Background. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in humans. There is a high unmet medical need to develop new therapies for the treatment of this disease. Read more
Understanding and rewiring tissue residency in Gamma-delta T cells
Stipend. £20,622 (inclusive of London allowance) per annum + Tuition Fees (Home) for 3 years. A consumables budget is also provided. Read more
The crosstalk between the duodenum and the pancreas: Profiling the immune system to identify the role of the gut in the pathogenesis of type 1 diabetes. MRC GW4 BioMed DTP PhD studentship 2024/25 Entry, PhD in Clinical and Biomedical Sciences
About the GW4 BioMed2 Doctoral Training Partnership. The partnership brings together the Universities of Bath, Bristol, Cardiff (lead) and Exeter to develop the next generation of biomedical researchers. Read more
Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity
The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more
How regulatory immunological cues (re)programme cellular metabolism to control effector T cell behaviour and function
Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more
Understanding tumour-mediated suppression of cytotoxic T cell function by rebuilding it in vitro
Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more
GW4 BioMed2 MRC DTP PhD project: Investigating how physical activity prevents cancers in humans: harnessing ‘big’ data to understand the genomic profile of human cancers that are preventable by physical activity.
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 20 studentships for entry in September 2024. Read more
MscR: Understanding tumour immune suppression using three-dimensional tumour target cell culture
Cytotoxic T cells have the potential to effectively kill tumour target cells. However, in the tumour microenvironment this potential is substantially suppressed. Read more
Elucidating T cell phenotype and function in frozen shoulder (NDORMS 2024/5)
Frozen shoulder is a disabling condition affecting 10% of the working population. Disease causes significant pain and immobility of the shoulder joint, reducing life quality of affected patients. Read more
Developing a novel cancer vaccine for low mutation burden tumours derived from the non-coding genome
Our laboratory aims to understand how mutation in tumour suppressors and oncogenes causes cancer. We focus on understanding the biochemical basis of oncogene and tumour suppressor activity in order to develop new cancer therapies. Read more