Exploring the pathogenic roles of Rab GTPases in models of taupathy
Prof F Giorgini, Prof C P Kyriacou
28 January 2019
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and the predominant cause of dementia. The main pathological hallmarks of the disease in the brain are the presence of amyloid plaques and neurofibrilliary tangles composed of hyperphosphorylated forms of tau (P-tau).
Inhibiting amyloid development using natural compounds: a molecular dynamics study
Dr P Mulheran, Dr V A Ferro
Applications accepted all year round
Amyloid fibrils are highly ordered protein aggregates associated with many neurodegenerative diseases such as Alzheimer’s. Flavanoids, which are polyphenols such as curcumin present in the human diet, have been shown to inhibit fibril formation in tau protein which is abundant in neurons.