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therapeutic PhD Projects, Programmes & Scholarships
We have 314 therapeutic PhD Projects, Programmes & Scholarships
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(EPSRC DTP) Interactions and therapeutic potential of graphene materials with brain cancer organoids
Glioblastoma (GM) is the most common and most aggressive brain tumour, as less than 5% of the patients survive more than 5 years. Read more
Cell-type dependent pharmacological regulation of cellular mitophagy for therapeutic application in Parkinson’s disease
The cellular quality-control process of mitophagy, entailing selective degradation of defective mitochondria (following damage to their DNA) by the process of autophagy, has attracted considerable research interest. Read more
Investigate the novel therapeutic potential for treating heart failure in diabetes.
Heart failure is the most common cause of mortality in diabetes patients, but current diabetes therapies have a limited impact on the incidence of heart failure in diabetic populations. Read more
The generation of RBCs in vitro from stem cell sources and the molecular regulation of erythropoiesis in health and disease: towards new therapeutic approaches
Development of systems for the generation of red blood cells (RBCs) from stem cell sources (adult peripheral blood, cord blood and induced pluripotent stem… Read more
Evaluating novel therapeutic strategies to target tumour metastases
Metastases are a frequently incurable and devastating outcome for many cancer patients with advanced disease. Read more
PhD in Vision Sciences: Evaluating functional outcomes of novel therapies for mitochondrial optic neuropathy using ultra-high resolution multi-electrode array
Mitochondrial optic neuropathies result in blindness and are currently untreatable. They arise as a consequence of genetic mutations in either mitochondrial or nuclear DNA and share the common characteristic of primarily affecting retinal ganglion cell (RGC) survival. Read more
Evaluation of the therapeutic potential of pharmacological NRF2 activation in hepatic fibrosis
This project is one of 17 four year PhD Studentships funded by Medical Research Scotland (. https://www.medicalresearchscotland.org.uk. Read more
Identification of cis- and trans-acting genetic modifiers of somatic expansion as novel therapeutic targets in the repeat expansion disorders
At least 40 human disorders, including Huntington disease and myotonic dystrophy, are caused by the expansion of a simple sequence repeat [1]. Read more
Assessing therapeutic strategies to target the counter-regulatory renin-angiotensin system in cardiovascular disease
Project outline: . The renin angiotensin system (RAS) is a hormonal cascade mediating cardiovascular function. The RAS is key to the development of cardiovascular diseases, including cardiac remodelling in hypertension and heart failure and atherosclerosis. Read more
4-year PhD Studentship: Endothelial glycocalyx damage as a therapeutic target in cardiopulmonary bypass associated acute kidney injury
Patients undergoing cardiopulmonary bypass (CPB) often develop acute kidney injury (AKI) caused by myocardial ischemia reperfusion injury (MIRI). Read more
Identifying novel therapeutic targets in CMML
Chronic myelomonocytic leukaemia (CMML) is a clonal stem cell neoplasm defined by abnormal monocytosis and dysplasia. A quarter of CMML patients progress to acute myeloid leukaemia and these patients have dismal prognosis. Read more
Small G proteins and their effectors as therapeutic targets in cancer
For the majority of cancers the acquisition of invasive and metastatic characteristics leads to incurable disease in the host. Read more
Developing fingerprint sampling as a completely non-invasive approach for therapeutic drug monitoring
Developing fingerprint sampling as a completely non-invasive approach for therapeutic drug monitoring . Project Description. Read more
Understanding the role of IKK in the tumour microenvironment and establishing it as a novel therapeutic target in colorectal cancer
TO APPLY CLICK 'INSTITUTION WEBSITE' . Colorectal cancer (CRC) remains the 2nd most common cancer and 3rd most common cause of cancer-related death globally. Read more
Developing new cancer therapeutic agents from foodstuff: characterizing galectin interaction with novel inhibitors
Applications will be reviewed until a suitable candidate is appointed. Galectins are a family of carbohydrate-binding proteins that are commonly over-expressed by many types of cancers such as colorectal, lung, breast, prostate cancer and melanoma. Read more