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therapy PhD Projects, Programmes & Scholarships

We have 263 therapy PhD Projects, Programmes & Scholarships

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We have 263 therapy PhD Projects, Programmes & Scholarships

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ABM CDT The mechanisms of portable negative pressure wound therapy on wounds

Wounds are a major unmet healthcare burden that impact on millions of patients per year. From those undergoing simple surgeries to complex ulcers of the lower limbs, a common form of therapy is the use of negative pressure wound therapy. Read more

Fluorescent nanoparticle arrays for label-free monitoring of immunotherapy for bladder cancer

Download the full project proposal PDF here. The biological response to cancer therapy is extremely varied and complex. As a result, designing tools which monitor perturbations of specific proteins or nucleic acids in liquid biopsies can be challenging and often lead to low specificities and/or sensitivities. Read more

Macrophage driven therapy resistance in AML: from macrophage subset characterisation to therapeutic targeting. (Ref SHLS20065)

  Research Group: Molecular Mechanisms and Long Term Conditions
Reference. SHLS20065. Background. Acute Myeloid Leukaemia (AML) is a common blood cancer in adults; with its incidence increasing with age, AML cases are predicted to double by 2030. Read more

Gene therapy for Alkaptonuria

Alkaptonuria (AKU) is caused by deficient activity of the enzyme HGD, resulting from over 200 mutations in the HGD gene loci, leading to the accumulation of a tyrosine metabolite called homogentisic acid (HGA). Read more

Tissue tropism in PD-1 therapy

Programmed cell death protein 1 (PD1) is an immune checkpoint receptor expressed on immature thymocytes as well as peripheral CD4+ and CD8+ T cells, Natural Killer T (NKT) cells, B cells, monocytes and subsets of dendritic cells upon activation. Read more

Laser-driven Proton Beam Therapy

Radiation therapy, a cornerstone of cancer treatment, is used in over 50% of cancer patients. The most frequently used types of radiotherapy employ photon or electron beams with MeV-scale energies. Read more

Self funded BMS Project: Understanding the population dynamics of haematopoietic stem cells during gene therapy for sickle cell disease

Applications accepted for PhD Only. Background. This project builds on the recent discovery that whole genome sequencing approaches in blood stem and progenitor cells can be used to estimate the number of actively contributing blood stem cells in humans (Lee-Six et al., Nature 2018). Read more

The development of bacteriophage as bionanoparticles for gene therapy

Gene therapy is at the forefront of innovations in healthcare. The key unmet need for transformative exploitation of gene therapy is to deliver genes to the correct tissue safely and with efficacy. Read more

Ex vivo investigations on the safety and effectiveness of gold nanorods photothermal therapy for liver cancer treatment

Project summary. Recent developments in nanomedicine have demonstrated the effectiveness of gold nanorods (GNRs) as photo-absorbers in enhancing the heat absorption effects during photothermal therapy (PTT) (Khan et al., 2021; Liao et al., 2021; Zong et al., 2021). Read more

PRIORITIZING DRUG COMBINATIONS IN LEUKEMIA BASED ON ANALYSIS OF TARGETTED THERAPY IN VIVO

The inhibition of BCR-associated kinases by so-called B cell receptor signalling inhibitors in B cell leukemia and lymphomas is a potent therapeutic strategy, and several BTK and PI3K kinase inhibitors are available for clinical use (Ondrisova and Mraz, 2020). Read more

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