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toxin PhD Projects, Programs & Scholarships

We have 10 toxin PhD Projects, Programs & Scholarships

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  Functional characterization of Neisserial toxin-antitoxin systems
  Dr N Oldfield, Dr D Turner
Applications accepted all year round

Funding Type

PhD Type

Toxin-antitoxin (TA) systems are commonly found in both Gram-positive and Gram-negative bacteria and comprise a stable toxin able to stall bacterial replication and an antitoxin that neutralises the activity of the toxin.
  Probing the organization and function of bacterial toxin-antitoxin complexes
  Dr F Hayes, Prof J P Derrick
Applications accepted all year round

Funding Type

PhD Type

Bacterial toxin-antitoxin (TA) modules typically consist of a pair of genes that encode for a stable toxin protein and an unstable cognate antitoxin molecule.
  Targeting pathogen subversion of cellular ageing to combat antimicrobial-resistant typhoid fever
  Dr D Humphreys, Dr T Darton
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial-resistant typhoid fever is fuelled by chronic Salmonella carriage. The world faces epidemics of untreatable typhoid fever caused by antimicrobial-resistant strains of Salmonella Typhi (~27 million cases/year).
  The role of pore-forming bacterial proteins in pneumonia and meningitis
  Prof T J Mitchell, Dr M Tomlinson
Applications accepted all year round

Funding Type

PhD Type

The bacterium Streptococcus pneumoniae (the pneumococcus) is carried in the nasopharynx of most children and some adults without causing disease.
  Molecular architecture of a DNA transfer machinery and its contribution to the dissemination of antibiotic resistance
  Prof T Forsyth, Dr D Traore
Application Deadline: 29 May 2020

Funding Type

PhD Type

Project title. Molecular architecture of a DNA transfer machinery and its contribution to the dissemination of antibiotic resistance genes.
  Molecular characterisation of novel virulence genes and vaccine candidates in pathogenic Corynebacterium diphtheria (Ref: SF20/APP/SANGAL)
  Dr V Sangal
Applications accepted all year round

Funding Type

PhD Type

Corynebacterium diphtheriae is a prominent human pathogen that causes diphtheria, a toxin mediated disease of upper respiratory tract, resulting in significant mortality and morbidity in humans.
  Temperate bacteriophages and Antimicrobial Resistance (AMR) (Ref: SF20/APP/SMITH2)
  Dr D Smith
Applications accepted all year round

Funding Type

PhD Type

Bacterial genomes are studded with prophage regions, some that can be stimulated to produce active phages that horizontally transfer their genomes between related bacterial species.
  Metabolic rewiring in liver cancer: Role of oxidative stress and the Nrf2 pathway
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Many of the major risks factors for developing liver cancer such as alcohol, obesity, smoking and toxin exposure share in common a role for oxidative stress.
  Dissipative particle dynamics (DPD)
  Research Group: Sustainable Electronic Technologies
  Prof A Brown
Application Deadline: 31 August 2020

Funding Type

PhD Type

Supervisor. Prof Andrew Brown. Project description. Scaling simulations of biological and chemical systems is reaching limits. the computational cost of simulating a physical system scales at least as fast as the cube of its linear dimension.
  Bacterial ABC transporters involved in antibiotic resistance and sensing
  Dr A Crow, Prof D Roper, Dr S Gebhard
Application Deadline: 7 June 2020

Funding Type

PhD Type

Type VII ABC transporters are a superfamily of ATP-powered membrane proteins that function in bacterial antibiotic resistance, toxin secretion, cell division and membrane biogenesis [1,2,3].
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