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  Molecular Mechanisms for the Regulation of IL-10 Production in T Cells
  Dr A O’Garra.
Application Deadline: 12 November 2019

Funding Type

PhD Type

This 4-year PhD studentship is offered in Dr Anne O’Garra’s Group based at the Francis Crick Institute (the Crick). Interleukin (IL)-10 is critical for limiting the immune response to pathogens, therefore preventing immunopathology [1].
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round

Funding Type

PhD Type

MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Microenvironmental interactions and regulation of their crosstalk in malignant B-cells by transcription factors
  Prof M Mráz
Application Deadline: 31 October 2019

Funding Type

PhD Type

We are looking for a motivated PhD student that would like to work on the following project funded by the ERC (European Research Council) Starting grant.
  Stopping transcription at the end of mammalian protein coding genes: How is this achieved and why does this matter
  Prof N J Proudfoot
Application Deadline: 10 January 2020

Funding Type

PhD Type

This research project will focus on my lab’s recent development of genomic methodology for nascent transcription analysis (1).
  Selective control of tRNA gene transcription by steroid receptors and BRCA1.
  Prof R J White, Dr W Brackenbury
Application Deadline: 5 January 2020

Funding Type

PhD Type

BRCA1 is an important tumour suppressor protein with roles in DNA repair. and transcription. BRCA1 binds many tRNA genes, but its role there is.
  Evolution of gene regulatory networks after gene duplication
  Research Group: Lymphocyte Development
  Prof M Merkenschlager, Dr P Sarkies
Application Deadline: 1 December 2019

Funding Type

PhD Type

Throughout evolution multicellular organisms have experienced large-scale structural alterations, in which regions of the genome or even the entire genome have been duplicated (1-7).
  Epigenetic regulation of meiotic genes by the transcription factor Hac1i
  Dr M Schroeder
Applications accepted all year round

Funding Type

PhD Type

A self-funded PhD studentship to investigate how the transcription factor Hac1i achieves epigenetic regulation of early meiotic genes is available in the group of Dr.
  Transcription factors mediating light input to the Arabidopsis circadian clock
  Dr P Devlin
Applications accepted all year round

Funding Type

PhD Type

The circadian clock is tightly tied to the light environment. Transcriptional feedback loops are able to generate a self-sustaining rhythm of approximately 24 hours which impinges on almost every aspect of physiology in higher organisms.
  Effects of transcription on genome stability
  Prof N J Savery
Applications accepted all year round

Funding Type

PhD Type

Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders.
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