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  Cancer Research UK funded 4 year studentship: RNA Pol II subunits in the regulation of transcription and genome instability
  Dr M Saponaro, Dr A Gambus
Application Deadline: 15 February 2019
Applications are invited for a non-clinical PhD studentship at the Cancer Research UK (CRUK) Birmingham Centre.
  Transcription regulation in the context of genome stability
  Dr M Saponaro
Applications accepted all year round
The DNA in our cells is a substrate for both RNA Pol II (RNAPII) transcription and DNA replication. Consequently, only one of the two processes can use the DNA as a template at any given time.
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round
MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round
The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  New insights into cell cycle-dependent control of transcription: implications for cancer
  Prof A Sharrocks, Dr P Shore
Applications accepted all year round
Defects in the cell cycle are the underlying basis to cancer. Work in my lab is aimed at understanding the molecular basis to tumourigenesis through studying pathways which impact on the cell cycle and are deregulated in cancer.
  Transcription factors mediating light input to the Arabidopsis circadian clock
  Dr P Devlin
Applications accepted all year round
The circadian clock is tightly tied to the light environment. Transcriptional feedback loops are able to generate a self-sustaining rhythm of approximately 24 hours which impinges on almost every aspect of physiology in higher organisms.
  Effects of transcription on genome stability
  Prof N J Savery
Applications accepted all year round
Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders.
  Role of the antioxidant transcription factor Nrf2 in determining susceptibility to non-alcoholic steatohepatitis in a human liver cell model
  Prof J D Hayes, Dr J F Dillon
Applications accepted all year round
Non-alcoholic fatty liver disease (NAFLD) is a major public health concern in the UK as it is associated with obesity, and has huge economic significance.
  Study of pioneer transcription factor dynamics during vertebrate Zygotic Genome Activation
  Research Group: MRC Human Genetics Unit
  Dr D Papadopoulos
Application Deadline: 18 January 2019
How do transcription factors (TFs) regulate development at the correct time, dosage and place? How do they “know” how to “find” their target sites in live cells, with ultimate precision and specificity? Many developmental disorders are caused by haploinsufficiencies of TFs, thus their concentration and molecular behaviour is critical for directing correct embryonic development.
  MRC DiMeN Doctoral Training Partnership: Why do multiple pathogenic viruses including HIV, Influenza, Ebola, Herpesviruses and Adenovirus target the cellular transcription machinery?
  Prof S A Wilson, Prof A Whitehouse
Application Deadline: 21 January 2019
Viruses frequently hijack cellular processes as part of their life cycle. A recent proteomics screen revealed a core of mammalian proteins which are targeted by multiple viruses, defining four critical cellular nodes in viral infections (Nature 487:486-490).
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