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transcription PhD Projects, Programs & Scholarships

We have 80 transcription PhD Projects, Programs & Scholarships

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  Transcription regulation in the context of genome stability
University of Birmingham Institute of Cancer and Genomic Sciences
  Dr M Saponaro
Applications accepted all year round
The DNA in our cells is a substrate for both RNA Pol II (RNAPII) transcription and DNA replication. Consequently, only one of the two processes can use the DNA as a template at any given time.
Details
Type/Funding
  Development of treatment for Osteoarthritis by blocking metalloproteinases
University of Liverpool Institute of Ageing and Chronic Disease
  Prof G Bou-Gharios
Applications accepted all year round
MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
Details
Type/Funding
  Understanding transcription mediated methylation of intragenic CpG islands in health and disease
University of Leicester Department of Genetics and Genome Biology
  Dr C Tufarelli, Prof S Cowley
Application Deadline: 5 May 2019
1. Project outline describing the scientific rationale of the project (max 4,000 characters incl. spaces and returns). DNA methylation is an epigenetic modification that affects gene expression without altering gene sequences.
Details
Type/Funding
  Structural mechanism of signal-dependent gene transcription
University of Leicester Molecular and Cell Biology
  Prof D Panne, Dr A Revyakin
Application Deadline: 5 May 2019
The control of gene transcription is one of the main regulatory steps for cellular gene regulation.
Details
Type/Funding
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
University of Cambridge Department of Biochemistry
  Prof E D Laue
Applications accepted all year round
The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
Details
Type/Funding
  New insights into cell cycle-dependent control of transcription: implications for cancer
University of Manchester Faculty of Biology, Medicine and Health
  Prof A Sharrocks, Dr P Shore
Applications accepted all year round
Defects in the cell cycle are the underlying basis to cancer. Work in my lab is aimed at understanding the molecular basis to tumourigenesis through studying pathways which impact on the cell cycle and are deregulated in cancer.
Details
Type/Funding
  The role of the transcription factor FLC in growth habit, fruit dimorphism and plant defense of Aethionema arabicum
Max Planck Institute for Chemical Ecology International Max Planck Research School
  Prof G Theißen, Prof J Gershenzon, Prof R Oelmüller
Application Deadline: 24 May 2019
Background. The genus Aethiomena has a phylogenetic position at the base of the crucifers (Brassicaceae) and is thus of interest for studying trait evolution in this ecologically and economically important plant family [1].
Details
Type/Funding
  Transcription factors mediating light input to the Arabidopsis circadian clock
Royal Holloway, University of London School of Biological Sciences
  Dr P Devlin
Applications accepted all year round
The circadian clock is tightly tied to the light environment. Transcriptional feedback loops are able to generate a self-sustaining rhythm of approximately 24 hours which impinges on almost every aspect of physiology in higher organisms.
Details
Type/Funding
  Effects of transcription on genome stability
University of Bristol School of Biochemistry
  Prof N J Savery
Applications accepted all year round
Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders.
Details
Type/Funding
  To study a cytoplasmic form of transcription factor AP4 that can control cell morphology and migration
Xi’an Jiaotong-Liverpool University Biological Sciences
  Dr S-K Chiu
Applications accepted all year round
Transcription factor AP4 is a nuclear protein known to control the gene expression related to cell proliferation, apoptosis, cell migration in human cancer cells.
Details
Type/Funding
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