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We have 60 transcription PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
transcription PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 60 transcription PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Epigenetic control of transcription factor regulation of adult neurogenesis in the dentate gyrus
In the adult brain, new neurons are continuously generated in the hippocampal dentate gyrus (DG). This neurogenesis process is highly regulated and consists of cell proliferation, neuronal differentiation, neuronal maturation and survival. Read more
Roles of negative transcriptional regulators in cancer cells
The aim of the project is to investigate how factors involved in mRNA synthesis alter gene expression in human cells. Precise control of transcription and RNA processing is essential for the correct regulation of gene expression in all eukaryotic organisms. Read more
Deciphering the regulation of NKX2-5, a key transcription factor in heart development, to uncover the fundamental mechanisms of cardiac cell development from stem cells
Our understanding of cardiac cell development remains incomplete, specifically how the progenitor cells, which give rise to the heart, are programmed to acquire cardiac potential. Read more
Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more
Haematology: Oncogenic mechanisms causing malignant transformation of B cells and plasma cells
Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Read more
The Survivin Interactome in Health and Disease
Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more
Haustoria-omics with proteomics, transcriptomics, and gene silencing, to understand fungal pathogenicity and plant resistance during powdery mildew disease in food crops
Powdery mildews (PMs) are prevalent plant diseases that compromise the production of many valuable food and horticultural crops, including cereals, strawberry, cucurbits and pea. Read more
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Identification and functional analysis of human mitochondrial mRNA regulatory factors
Laboratory of RNA Biology IBB PAS. seeks a highly motivated PhD Student candidate who would like to join a mitochondrial research group working under the supervision of Dr Roman Szczesny. Read more
Circadian mechanisms in psoriasis: therapeutic opportunities
Hallmark features of psoriasis symptoms vary through time, suggesting an important role for circadian circuits in driving disease expression, and offering the potential of chronotherapy. Read more
Design, construction and testing of recombinant protein production systems for industrial biotechnology applications.
The production of recombinant biopharmaceuticals, e.g., antibody fragments and growth hormones, is a billion-dollar industry, with many therapeutic proteins being expressed in the bacterium Escherichia coli [1]. Read more
Cell-biological mechanisms mediating primary cilium mediated interpretation of Shh signalling during vertebrate neuronal differentiation
Newborn neurons undergo extensive morphological changes as they polarise to extend axons. In the developing spinal cord, newborn neurons extend axons towards their targets in response to cues from the surrounding tissues. Read more
Using synthetic biology to understand the evolution of antibiotic resistance
Imagine an architect, tasked with converting an old stadium into a building with a different function, without demolishing it. Read more
Using statistical and functional analysis to investigate the contrasting disease specific roles of IL6R and the chr17q12 locus in the development of rheumatoid arthritis and asthma
The Arthritis Research UK and Respiratory Centres at the University of Manchester have extensive research programmes investigating the genetic components of rheumatoid arthritis (RA) and asthma. Read more
Role of the ribosomal exit tunnel in translation regulation
Ribosomes are the cellular machines that synthesise all proteins within cells. Cells regulate gene expression at multiple levels beyond transcription and control of translation is a key regulatory step both at a global level and for individual mRNAs. Read more
The analysis of HIF function in DNA repair and genome stability
DNA damage is a factor that underlies many human diseases. Such damage results in mutations, and if such genetic alterations occur in tumour suppressor or proto-oncogenes it can lead to cancer. Read more