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transcription PhD Projects, Programs & Scholarships

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  Transcription regulation in the context of genome stability
  Dr M Saponaro
Applications accepted all year round
The DNA in our cells is a substrate for both RNA Pol II (RNAPII) transcription and DNA replication. Consequently, only one of the two processes can use the DNA as a template at any given time.
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round
MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
  Understanding transcription mediated methylation of intragenic CpG islands in health and disease
  Dr C Tufarelli, Prof S Cowley
Application Deadline: 5 May 2019
1. Project outline describing the scientific rationale of the project (max 4,000 characters incl. spaces and returns). DNA methylation is an epigenetic modification that affects gene expression without altering gene sequences.
  Structural mechanism of signal-dependent gene transcription
  Prof D Panne, Dr A Revyakin
Application Deadline: 5 May 2019
The control of gene transcription is one of the main regulatory steps for cellular gene regulation.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round
The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  New insights into cell cycle-dependent control of transcription: implications for cancer
  Prof A Sharrocks, Dr P Shore
Applications accepted all year round
Defects in the cell cycle are the underlying basis to cancer. Work in my lab is aimed at understanding the molecular basis to tumourigenesis through studying pathways which impact on the cell cycle and are deregulated in cancer.
  The role of the transcription factor FLC in growth habit, fruit dimorphism and plant defense of Aethionema arabicum
  Prof G Theißen, Prof J Gershenzon, Prof R Oelmüller
Application Deadline: 24 May 2019
Background. The genus Aethiomena has a phylogenetic position at the base of the crucifers (Brassicaceae) and is thus of interest for studying trait evolution in this ecologically and economically important plant family [1].
  Transcription factors mediating light input to the Arabidopsis circadian clock
  Dr P Devlin
Applications accepted all year round
The circadian clock is tightly tied to the light environment. Transcriptional feedback loops are able to generate a self-sustaining rhythm of approximately 24 hours which impinges on almost every aspect of physiology in higher organisms.
  Effects of transcription on genome stability
  Prof N J Savery
Applications accepted all year round
Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders.
  To study a cytoplasmic form of transcription factor AP4 that can control cell morphology and migration
  Dr S-K Chiu
Applications accepted all year round
Transcription factor AP4 is a nuclear protein known to control the gene expression related to cell proliferation, apoptosis, cell migration in human cancer cells.
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