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transcription PhD Projects, Programmes & Scholarships
We have 69 transcription PhD Projects, Programmes & Scholarships
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Transcription: molecular mechanisms & dynamics
This project is available through the MIBTP programme. The successful applicant will join the MIBTP cohort and will take part in all of the training offered by the programme. For further details. Read more
Coordination between RNAPII transcription and DNA replication
RNA Pol II (RNAPII) transcription and DNA replication are the two essential-for-life processes that use as a substrate the DNA in our cells, allowing the¬¬m to express the content of their genetic information and to propagate these instructions to daughter cells. Read more
Transcription factor complexes in Acute Myeloid Leukaemia
Acute Myeloid Leukaemia (AML) is a group of blood cancers, resulting from uncontrolled cellular proliferation of cells belonging to the myeloid lineage. Read more
Role of RNA-DNA hybrids and transcription-replication conflicts in colorectal cancer
Replication stress, or replication-associated DNA damage, occurs frequently in cancer. There is a growing interest in targeting oncogene-induced replication stress for cancer therapy. Read more
Defining the transcription roles of BRCA1 and BRCA2
BRCA1 and BRCA2 mutations predispose to both breast and ovarian cancers, with both factors playing many crucial roles in DNA damage repair and response. Read more
Effects of transcription on genome stability
Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders. Read more
The role of non-coding RNAs and epitranscriptomics in shaping 3D chromatin architecture in stem cells.
We are looking for an enthusiastic PhD student interested in working on non-coding RNAs and chromatin architecture at the Center for Human Technologies @IIT (Genova-Italy). Read more
Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more
Long noncoding RNA control of Drosophila Hox gene expression
Variation in gene regulation between animals often explains differences between species and individuals, and perturbed gene expression frequently underlies disease states. Read more
Going across temporal scales: how are oscillatory dynamics of protein expression decoded in the expression of downstream genes in neurogenesis?
In recent years, our understanding of gene expression dynamics has been transformed by single-cell, molecular and imaging technologies. It was thought that genes are simply “on” or “off”, but we now appreciate that the dynamics are more complex. Read more
How do individual histone modifications help cells make decisions?
We are looking for a highly-motivated, independent-thinking candidate to undertake a PhD project exploring the role of individual histone modifications in nuclear organisation, regulation of transcription, and the process of stem cell fate decisions. Read more
Laboratory of Gene Regulation
Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more
Laboratory of Gene Regulation
Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more
Nutritional enhancement of fruits and vegetables
Background. A wealth of scientific evidence now exists to show that diets rich in fruits and vegetables are beneficial to human well-being and health [1]. Read more
Diversifying the histone code: defining the role of non-canonical phosphorylation in chromatin structure
This opportunity will remain open until the position has been filled. Post-translational modifications (PTMs) of histones are known to direct chromatin structure and thus gene transcription. Read more