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transcription PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

We have 60 transcription PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

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Epigenetic control of transcription factor regulation of adult neurogenesis in the dentate gyrus

In the adult brain, new neurons are continuously generated in the hippocampal dentate gyrus (DG). This neurogenesis process is highly regulated and consists of cell proliferation, neuronal differentiation, neuronal maturation and survival. Read more

Roles of negative transcriptional regulators in cancer cells

The aim of the project is to investigate how factors involved in mRNA synthesis alter gene expression in human cells. Precise control of transcription and RNA processing is essential for the correct regulation of gene expression in all eukaryotic organisms. Read more

Understanding the gene regulatory landscape of embryonic stem cells and cancer cells

Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more

The Survivin Interactome in Health and Disease

Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more
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Identification and functional analysis of human mitochondrial mRNA regulatory factors

Laboratory of RNA Biology IBB PAS. seeks a highly motivated PhD Student candidate who would like to join a mitochondrial research group working under the supervision of Dr Roman Szczesny. Read more

Circadian mechanisms in psoriasis: therapeutic opportunities

Hallmark features of psoriasis symptoms vary through time, suggesting an important role for circadian circuits in driving disease expression, and offering the potential of chronotherapy. Read more

Design, construction and testing of recombinant protein production systems for industrial biotechnology applications.

The production of recombinant biopharmaceuticals, e.g., antibody fragments and growth hormones, is a billion-dollar industry, with many therapeutic proteins being expressed in the bacterium Escherichia coli [1]. Read more

Role of the ribosomal exit tunnel in translation regulation

Ribosomes are the cellular machines that synthesise all proteins within cells. Cells regulate gene expression at multiple levels beyond transcription and control of translation is a key regulatory step both at a global level and for individual mRNAs. Read more

The analysis of HIF function in DNA repair and genome stability

DNA damage is a factor that underlies many human diseases. Such damage results in mutations, and if such genetic alterations occur in tumour suppressor or proto-oncogenes it can lead to cancer. Read more

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