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  Structural investigation of Sam68-driven transcription/splicing coupling
  Dr C Dominguez, Prof I C Eperon
Application Deadline: 6 January 2019
The identification of 20-25,000 human genes by the human genome project came as a big surprise since the estimated number of human proteins is around 130,000.
  Interplay between RNA Pol II transcription and DNA replication
  Dr M Saponaro, Dr M Higgs
Application Deadline: 6 January 2019
Background. RNA Pol II transcription and DNA replication are the two essential processes that use as a substrate the DNA in our cells, allowing them to express the content of their genetic information and to propagate these instructions to daughter cells.
  Transcription regulation in the context of genome stability
  Dr M Saponaro
Applications accepted all year round
The DNA in our cells is a substrate for both RNA Pol II (RNAPII) transcription and DNA replication. Consequently, only one of the two processes can use the DNA as a template at any given time.
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round
We aim to understand how MMP13 is transcriptionally regulated and whether a newly identified enhancer is involved in normal and osteoarthritic cartilage.
  Post-translational regulation of transcription dynamics in plant immunity
  Research Group: Institute of Molecular Plant Sciences
  Dr S Spoel, Dr G van Ooijen
Application Deadline: 13 December 2018
Precise regulation of gene transcription is vital for all organisms. In eukaryotes, dynamic changes in gene transcription orchestrate cell development and cellular responses to the ever changing environment.
  Understanding transcription mediated methylation of intragenic CpG islands in health and disease
  Dr C Tufarelli, Prof S Cowley
Application Deadline: 6 January 2019
1. Project outline describing the scientific rationale of the project (max 4,000 characters incl. spaces and returns). DNA methylation is an epigenetic modification that affects gene expression without altering gene sequences.
  Structural mechanism of signal-dependent gene transcription
  Prof D Panne, Dr A Revyakin
Application Deadline: 6 January 2019
The control of gene transcription is one of the main regulatory steps for cellular gene regulation.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round
The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Collisions of replication and transcription machinery in Escherichia coli.
  Dr M Hawkins, Dr D Barilla, Dr A Wollman
Application Deadline: 7 January 2019
DNA duplication is essential for life. Numerous proteins bind and interact with DNA. When replication forks collide with proteins bound to DNA they can be blocked and this causes problems for genome stability.
  Biochemical analysis of the interaction of pluripotency transcription factors with RNA polymerase enzymes
  Research Group: Institute of Stem Cell Research
  Prof I Chambers
Application Deadline: 13 December 2018
Pluripotent stem cells possess the dual defining properties of self-renewal and multi-lineage differentiation potential. In order to retain an effective differentiation capacity, self-renewal must occur at high efficiency.
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