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  Understanding the role that the RNA helicase UPF1 plays in sorting ribonucleoprotein (RNP) complexes and the mechanism by which this role of UPF1 might reduce cellular stress and cell degeneration.
  Research Group: BBSRC MIBTP
  Dr S Brogna
Application Deadline: 7 January 2020

Funding Type

PhD Type

This project’s specific objective is to study the molecular role(s) that the RNA helicase UPF1 plays in RNA processing. UPF1 is a key player in nonsense-mediated mRNA decay (NMD), it is universally conserved in eukaryotes and is essential to the development of many organisms [1].
  The generation of RBCs in vitro from stem cell sources and the molecular regulation of erythropoiesis in health and disease
  Dr J Frayne
Applications accepted all year round

Funding Type

PhD Type

Development of systems for the generation of red blood cells (RBCs) from stem cell sources (adult peripheral blood, cord blood and pluripotent stem cells)…
  Identifying genomic and epigenetic factors in different subtypes of pancreatic cancer
  Prof J Carroll
Application Deadline: 15 November 2019

Funding Type

PhD Type

Despite recent advances in the treatment of pancreatic adenocarcinoma (PDAC), the median survival remains. Epigenetic pathway alterations are an emerging mechanism for PDA progression.
  Precision Medicine DTP - Synthetic chromosomes to understand genome instability
  Research Group: MRC Human Genetics Unit
  Prof N Gilbert, Prof A Marston
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Genomic instability in cancer has been known for many years; the advent of genomic analyses in the late 1990’s enabled these changes to be characterized in detail.
  EASTBIO Unravelling mechanisms controlling gene expression noise in S. cerevisiae during rapid adaptive responses and its application to biotechnology.
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr S Granneman
Application Deadline: 5 January 2020

Funding Type

PhD Type

Microbes are constantly subjected to changes in their environment and have to rapidly alter their transcriptome to adapt efficiently.
  Investigating the role of centromeric RNA transcripts for centromere function and inheritance
  Research Group: Institute of Cell Biology
  Dr P. Heun, Dr A Kerr
Application Deadline: 5 January 2020

Funding Type

PhD Type

The centromere is a unique chromatin domain important for proper segregation of chromosomes during mitosis.
  Unravelling mechanisms controlling gene expression noise in S. cerevisiae during rapid adaptive responses and its application to biotechnology.
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr S Granneman, Prof P Swain
Application Deadline: 5 January 2020

Funding Type

PhD Type

Microbes are constantly subjected to changes in their environment and have to rapidly alter their transcriptome to adapt efficiently.
  Hypoxia links the unfolded proteim response with the DNA damage response
  Prof E Hammond, Prof A Giaccia
Application Deadline: 10 January 2020

Funding Type

PhD Type

THE PROJECT. Regions of hypoxia (insufficient oxygen) occur in most if not all solid tumours and are clinically relevant as they correlate with poor patient prognosis and therapy resistance.
  Laboratory of Gene Regulation
  Prof D Higgs, Prof J Hughes, Dr R Gibbons, Dr V Buckle
Application Deadline: 10 January 2020

Funding Type

PhD Type

Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation.
  Laboratory of Gene Regulation
  Prof D Higgs, Prof J Hughes, Dr R Gibbons, Dr V Buckle
Application Deadline: 10 January 2020

Funding Type

PhD Type

Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation.
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