We have 22 transcriptome PhD Projects, Programmes & Scholarships

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transcriptome PhD Projects, Programmes & Scholarships

We have 22 transcriptome PhD Projects, Programmes & Scholarships

Transcriptome homeostasis in cellular ageing and cancer

Project Summary. We have previously established the oncogenic mechanisms of the transcription factor FOXM1 in perturbation of genome stability (1, 2), epigenome (3, 4) and adult progenitor epithelial stem cell proliferation (5). Read more

Probing the Dark Transcriptome: Leveraging Third-Generation RNA-Sequencing, Proteomics, and Deep Learning for the Discovery of Expressed Transcripts

This collaborative project with QUB cancer vaccine Spin-Out AilseVax, is focussed on developing computational methodologies for identifying and validating novel tumour-specific antigens (TSAs) in the “dark transcriptome/translatome from multi-omic and mass spectrometry (MS) data. Read more

Transcriptome biomarkers and mechanisms of chemoresistance

Project Summary. This project aims to identify biomarkers linked to the most potent multimodal anticancer therapy with the least toxicity to counteract hemoresistance in head and neck squamous cell carcinoma (HNSCC). Read more

The role of non-productive RNA splicing in gene expression

RNA splicing is an important step in pre-mRNA processing, where introns are removed from the transcribed pre-mRNA and the remaining exons form mature mRNA. Read more

Elucidating the functions and regulations of mRNA isoforms and modifications in yeast and mammalian cells

Cell differentiation programs depend on dynamic and global changes in gene expression to ensure proper morphologic changes. How regulation of gene expression is controlled during cell fate changes is often not well understood. Read more

Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more
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Investigating the role of dysregulated RNA processing in neurodegeneration

The Langley Lab at the School of Biosciences at Cardiff University is looking for a PhD student to join their research program investigation dysregulated RNA processing in neurodegeneration. Read more

Manipulation of neuroimmune responses and behaviour by infectious agents

This project is available exclusively to self-funded students who wish to commence study for a PhD in the academic year 2023/24. The project focuses on how infectious agents modify the individuals that they infect and how neuroimmune responses to infection moderate behaviour changes in warm-blooded animals and humans. Read more

Systems immunology and multi-omics approaches to understand protective immunity to human malaria

This PhD project aims to develop and apply computational approaches that integrate systems biology and molecular immunology to understand host-pathogen immunity and predict immune control of malaria. Read more

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