The central dogma of molecular biology states that genetically encoded information flows from DNA to mRNA to protein. The flow from DNA to mRNA occurs through a process called transcription and the flow from mRNA to protein through a process called translation.
Hepatitis C virus (HCV) causes a clinically important disease affecting 3% of the world population (Chan 2014). About 75% of the infection will develop into chronic hepatitis, which can then progress into fibrosis, cirrhosis and hepatocellular carcinoma.
Language and Communication Studies has come fifth in the UK with 74 per cent of its research rated 4* (world leading) or 3* (internationally excellent) in The Research Excellence Framework (REF2014), a major Government analysis of university research quality.
Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.
The cultural history of translation in early modern Europe is a new and vibrant area of research. Applications are invited for PhD study in this area, to be supervised by Dr Hilary Brown, Lecturer in Translation Studies and German at the University of Birmingham.