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We have 21 ubiquitin PhD Projects, Programmes & Scholarships

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ubiquitin PhD Projects, Programmes & Scholarships

We have 21 ubiquitin PhD Projects, Programmes & Scholarships

The role of ubiquitin-modifying enzymes in angiogenesis

The School of Molecular & Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

A versatile approach to targeting mechanosensitive deubiquitinating enzymes (DUBs) in tissue damage and chronic inflammation using Molecularly Imprinted Nanoparticle Inhibitors (MINIs).

Inflammation is an essential defence mechanism adapted by our bodies to eliminate damaged cells, irritants and pathogens. However, persisting inflammation that fails to resolve promotes or contributes to a number of chronic diseases including cancer, rheumatoid arthritis and musculoskeletal diseases. Read more

Structural biology tools to investigate and target ubiquitin system proteases in cancer

Ubiquitination targets proteins for degradation and regulates virtually all cellular signalling pathways in eukaryotes. The human genome encodes over 50 ubiquitin specific proteases (USPs) that cleave ubiquitin from modified proteins to salvage them from proteasomal degradation. Read more

Structural and functional characterisation of MALT1 ubiquitination to aid in the development of novel anti-cancer therapies

Nuclear factor-kappa B (NF-kB) is a family of transcription factors that play a crucial role in regulating various cellular processes; primarily related to immune responses, inflammation, and cell survival. Read more

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