Chemical profiling of ubiquitin conjugation enzymes
Dr S Virdee
31 December 2018
A PhD project in the Virdee lab is available involving the development of chemical tools known as activity-based probes (ABPs). ABPs measure the activity of disease-relevant enzymes and the Virdee lab have developed these for the enzymes that conjugate ubiquitin to substrates (1-3).
Discovery of ubiquitin-conjugation enzyme inhibitors from marine natural products.
Institute of Quantitative Biology, Biochemistry and Biotechnology
Prof M Auer, Dr N Carragher
13 December 2018
Ubiquitination is a key biochemical event which regulates most cell processes. Proteins are modified with ubiquitin, or ubiquitinated, through a series of reactions involving the E1, E2 and E3 enzymes.