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We have 23 ubiquitin PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

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ubiquitin PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

We have 23 ubiquitin PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

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Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

(EPSRC DTP) Mapping ubiquitin-like protein interactions using tailored photo-crosslinking chemistry

Posttranslational modification (PTM) of proteins is key to virtually all cellular activities. This includes the DNA damage response (DDR), a signalling network critical for facilitating healthy ageing by preventing age-related diseases such as cancer and neurodegenerative pathologies. Read more

How does the human fungal pathogen, Candida albicans, exploit its metabolic flexibility to enhance its virulence?

  Research Group: Edinburgh Infectious Diseases
Project offered for Ker Memorial PhD Studnetship in Infectious Diseases. Fungal pathogens kill over a million people every year. The most common human fungal pathogen is Candida albicans, a WHO-priority target. Read more

Structural and Mechanistic Chemical Biology of Degraders Mode of Actions

Pioneering discoveries from the Ciulli Laboratory have contributed to the establishment of a new modality of chemical intervention into biological systems. Read more

Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function. Read more

Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling

Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more

Understanding and controlling β-strand mediated PPIs using bespoke chemical modifications

Intrinsically disordered regions (IDRs)[1], are ubiquitous stretches of protein that do not adopt a stable structure, are a major class of protein structure found in all living organisms, and, are predicted to be present in around a third of eukaryotic proteins. Read more

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