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We have 23 ubiquitin PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
ubiquitin PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 23 ubiquitin PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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MSc by Research: Deciphering the ubiquitin codes that regulate protein degradation
Ubiquitin signalling, which involves the posttranslational modification (PTM) of proteins with ubiquitin, regulates almost every aspect of eukaryotic biology. Read more
Ubiquitin and ubiquitin-like proteins in the DNA damage response and cancer
A self-funded PhD studentship is available in the laboratories of Christine Schmidt, Stefan Meyer and Anthony Whetton. Read more
Ion mobility mass spectrometry investigations into the conformations and complexes of ubiquitin shuttle proteins
Summary. During this PhD project you will use ion mobility mass spectrometry to investigate the conformations of ubiquitin (Ub) shuttle proteins. Read more
Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation
Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more
(EPSRC DTP) Mapping ubiquitin-like protein interactions using tailored photo-crosslinking chemistry
Posttranslational modification (PTM) of proteins is key to virtually all cellular activities. This includes the DNA damage response (DDR), a signalling network critical for facilitating healthy ageing by preventing age-related diseases such as cancer and neurodegenerative pathologies. Read more
MycoTACs: Proteome targeting chimeras for Mycobacterium tuberculosis
PROteolysis Targeting Chimeras (PROTACs) are a promising and recent technological development utilised in the degradation of proteins in eukaryotes. Read more
How does the human fungal pathogen, Candida albicans, exploit its metabolic flexibility to enhance its virulence?
Research Group:
Edinburgh Infectious Diseases
Project offered for Ker Memorial PhD Studnetship in Infectious Diseases. Fungal pathogens kill over a million people every year. The most common human fungal pathogen is Candida albicans, a WHO-priority target. Read more
Structural and Mechanistic Chemical Biology of Degraders Mode of Actions
Pioneering discoveries from the Ciulli Laboratory have contributed to the establishment of a new modality of chemical intervention into biological systems. Read more
MSc by Research: Understanding the beginning of life: the role of non-canonical ubiquitylation in early embryonic development
Ubiquitin is a small, yet influential, protein that is attached to other substrates to control their stability or activity in a process called ubiquitylation. Read more
MSc By Research: Axonal Trafficking of opioid receptors
Opioid Receptors are responsible for the modulation and sensitivity to pain and are important targets for clinical analgesics such as morphine. Read more
MSc by Research: Targeted protein degradation in plants – developing “Green PROTACs” for functional analysis of lethal genes
Climate change is one of the biggest threats to global food production, leading to unpredictable weather patterns and geographical migration of pathogens. Read more
Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials
Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function. Read more
Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling
Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more
Understanding and controlling β-strand mediated PPIs using bespoke chemical modifications
Intrinsically disordered regions (IDRs)[1], are ubiquitous stretches of protein that do not adopt a stable structure, are a major class of protein structure found in all living organisms, and, are predicted to be present in around a third of eukaryotic proteins. Read more
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