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ubiquitin PhD Projects, Programmes & Scholarships

We have 21 ubiquitin PhD Projects, Programmes & Scholarships

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We have 21 ubiquitin PhD Projects, Programmes & Scholarships

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Ubiquitin signals in Parkinson’s disease

Ubiquitin signalling controls almost every cellular process in humans, including targeting poorly folded proteins for destruction to prevent them harming the cell. Read more

Ubiquitin-like modifications underlying Cell Differentiation and Biology in Trypanosomes

Post-translational protein modifications are major regulators of eukaryotic cell functions and include modifications by attachment of polypeptides such as ubiquitin and ubiquitin-like proteins (UBLs). Read more

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

Institute of Molecular, Cell and Systems Biology

 Our institute houses a multi-disciplinary centre of excellence conducting fundamental and translational life science research underpinning health and food security. Read more

MSc by Research: Investigating mitochondrial autophagy mechanisms in Parkinson’s

Our lab has contributed to how two Parkinson’s disease-linked genes encoding the protein kinase, PINK1 and ubiquitin E3 ligase, Parkin, orchestrate a mitochondrial quality control pathway found in nearly every cell type including neurons. Read more
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(EPSRC DTP) Mapping SUMO interactions in DNA repair using EPR, NMR and molecular modelling

Understanding the process by which DNA double-strand breaks are repaired via non-homologous end joining (NHEJ) is vital for the design and precision of future anti-cancer medicines and the optimisation of CRISPR/Cas9-based gene editing. Read more

MSc by Research: Regulation of the stability of the Notch intracellular domain in iPS derived presomitic mesoderm cells

Notch is one of the major highly conserved signalling pathways that regulate cell-cell communication which involves gene regulation mechanisms that control multiple processes during development and adult life. Read more

MSc by Research: Non-canonical functions of SRSF protein kinase (SRPK) in pluripotent stem cells

The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. . Read more

MSc by Research: Does CDK1 regulate NICD turnover in a cell cycle dependant manner in Drosophila Melanogaster?

Notch is one of the major highly conserved signalling pathways that regulate cell-cell communication which involves gene regulation mechanisms that control multiple processes during development and adult life, including cell fate specification within progenitors. . Read more

Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more

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