Cardiovascular disease is the leading cause of premature death in chronic kidney disease [1] and proteinuria is an independent risk factor of cardiovascular mortality [2]. Read more
Reduced blood flow and a breakdown of the protective blood-brain barrier (BBB) are major contributors to the development of cognitive decline and disease pathology in the early stages of dementia [1]. Read more
Cellular senescence is a mechanism that is activated in stressed cells to prevent the replication of damaged DNA. Senescent cells are found in vessel walls as well as in other tissues and have been shown to play a role in ageing and age-related diseases such as cardiovascular disease. Read more
Many chemotherapies and intravenous feeds require central venous access to allow the infusion of high osmolality fluids which would thrombose smaller, peripheral veins. Read more
G protein-coupled receptors (GPCRs) constitute a very large family of heptahelical, integral membrane proteins that mediate a wide variety of physiological processes ranging from the transmission of light and odorant signals to the mediation of neurotransmission and hormonal actions. Read more
Overview. Applications are invited for a fully funded PhD position on blood vessel function. The project will work across traditional scientific boundaries to explore vascular cell signalling in vascular tissues. Read more
Loughborough University is a top-ten rated university in England for research intensity (REF, 2014) and an outstanding 66% of the work of Loughborough’s academic staff who were eligible to be submitted to the REF was judged as ‘world-leading’ or ‘internationally excellent’, compared to a national average figure of 43%. Read more
Arterial damage is caused by caused by excess lipids, infections and other stresses. This can manifest as loss or damage to the innermost layer of artery walls, the endothelium. Read more
Despite significant advancements in its treatment coronary artery disease is the leading cause of death in both the UK and world-wide, accounting for over 66,000 deaths in the UK each year. Read more
Sprouting of new capillaries from pre-existing vessels (angiogenesis) promotes the formation of almost all blood vessels during development, growth and tissue regeneration. Read more
The brain’s vasculature forms part of a highly specialized structure called the blood-brain barrier (BBB). The primary role of the BBB is to prevent damaging compounds or pathogens in the blood from entering the brain, while efficiently delivering essential nutrients to brain tissue. Read more
Vitamin D3 deficiency is a common public health problem worldwide that is increasingly believed to contribute not only to decreased bone mineralisation but potentially to other serious medical conditions. Read more
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