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virulence PhD Projects, Programmes & Scholarships
We have 25 virulence PhD Projects, Programmes & Scholarships
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EASTBIO: Analysis of factors underlying host-specificity and virulence of Salmonella serovars
Supervisors. Dr Massimiliano Baldassarre. - Institute of Medical Sciences, University of Aberdeen. Massimiliano.baldassarre@abdn.ac.uk. Read more
Mechanisms of growth and virulence in Mycobacterium tuberculosis and other pathogenic mycobacteria
Sequenced genomes of mycobacteria, including the human tuberculosis causing pathogen Mycobacterium tuberculosis, reveal a number of genes dedicated to lipid biosynthesis and transport. Read more
Structural and biological characterisation of virulence factor in Gram-negative pathogens affecting aquaculture
Gram-negative pathogens are responsible for major disease problems in humans and animals, and a better understanding of the mechanisms for how these bacteria cause infections is key to identifying more effective ways to prevent and treat outbreaks. Read more
MSc by Research: Mechanisms underlying aphid effector virulence activity
Pests and diseases are a major threat to food security with losses ranging between 20-40%. Aphids are one of the most devastating insect pests, globally. Read more
Exploiting the protein O-Glycosylation pathway in opportunistic bacteria as an novel antimicrobial target
The problem. Antibiotic resistance has become a global health problem of epidemic proportions, especially for infections caused by Gram-negative bacteria. Read more
Elucidating the mechanisms of outer membrane biogenesis in Gram-negative bacteria
The emergence of bacteria that are resistant to available antibiotics represents an enormous and growing global threat requiring new targets and strategies to combat infection. Read more
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Understanding the role of fungal effector proteins in antagonistic fungus–microbe interactions
Background. Fungi secrete a collection of proteins to their surrounding environments. In the case of plant-pathogenic fungi, many of these proteins are virulence factors, termed effectors, which function to promote host colonization through the modulation of plant physiology or immunity1. Read more
Investigating the impact of electronic cigarette vapour on respiratory microbiota and inflammation
The use of electronic cigarettes (e-cigs) are increasing, despite very limited knowledge as to their safety and effect on the lung microbiome and inflammatory… Read more
Understanding the commensal-to-pathogen transition – environmental cues and signalling cascades
Summary. The yeast Candida albicans is a common commensal of the human gastrointestinal tract. Using a combination of microbiology, molecular biology, protein biochemistry and proteomics methods, this project aims to define the role of a Hsp90 phospho-switch . Read more
Interactions between the pathogenic Neisseria (N. meningitidis and N. gonorrhoeae) and human cells
Neisseria meningitidis (the meningococcus) is usually a harmless commensal bacterium which colonises the human nasopharynx. As far as is known humans are its only natural reservoir. Read more
Targeting the control of antimicrobial efflux in Mycobacterium tuberculosis to combat MDR-TB
We need more drugs for tuberculosis (TB), particularly multi-drug resistant (MDR) TB. TB treatment length (currently up to 24 months) needs to be shortened by using more effective drug combinations. Read more
Developing gregarine apicomplexans as aquatic symbiosis model system
The Gordon and Betty Moore Foundation’s Symbiosis in Aquatic Systems Initiative, seeks to advance the understanding of aquatic symbioses that include microbial partners. Read more
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Ultrastructural insights into avian herpesvirus-host cell interactions
Marek’s disease virus (MDV) is a major avian alphaherpesvirus associated with Marek’s disease (MD) in poultry characterised by rapid-onset T-cell lymphomas, immunosuppression and paralysis causing annual economic losses of around $2 billion worldwide. Read more
Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year. Read more
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EASTBIO: Monoclonal antibodies targeting the fungal cell surface: next generation antifungal therapeutics
Supervisors. Professor Carol Munro -. University of Aberdeen, Institute of Medical Sciences - c.a.munro@abdn.ac.uk. Professor Daan Van Aalten. Read more
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