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vivo PhD Projects, Programmes & Scholarships
We have 212 vivo PhD Projects, Programmes & Scholarships
Understanding the stress biology underlying human haematopoietic stem cell adaptation to clinically-relevant ex vivo culture
Project Overview. Haematopoietic Stem Cell (HSC) Gene Therapy (GT) is the only curative option for many monogenic inherited disorders. Read more
Last chance to apply
Mechanisms determining the protective impact of the farm environment in the development of early – life allergy and asthma
Applications are invited for a 3-year PhD studentship starting in mid-late autumn 2024 from candidates with a Master’s degree (Merit and above) in Immunology or a related discipline. Read more
Exploring the similarities between neointimal formation after vascular injury and tumour growth
Vascular smooth muscle cell (VSMC) proliferation leads to intimal thickening, which causes reoccurrence of symptoms (restenosis) in 30-50% of coronary artery disease patients receiving saphenous vein grafts and individual receiving stent implantation. Read more
Targeting acute inflammation to reduce coronary artery vein graft failure using bioengineering
The long saphenous vein (LSV) is the most commonly used conduit in cardiac surgery to treat patients with coronary artery disease; however, its use is complicated by high failure rates due to the development of vascular inflammation, intimal hyperplasia (IH) and accelerated atherosclerosis. Read more
Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy
Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more
Gene Editing approach as treatment for neurodevelopmental disorders
Background. Patients with neurodegenerative and neurodevelopmental disorders are currently offered in efficient therapeutic options that fails to slow down disease progression. Read more
Engineering Resolution – mRNA targeting of chronic inflammatory disease
mRNA based technologies have revolutionised vaccines and have the potential to modulate not just immunity to pathogens but also re-engineer immune responses to resolve chronic inflammatory disease. Read more
How do secreted phospho-proteins dictate fibroblast-neutrophil crosstalk in treatment resistant inflammatory bowel disease?
People who develop ulcerative inflammatory bowel disease (IBD) exhibit severe symptoms and do not respond to any current therapies. Pathology is driven… Read more
Microbiome metabolites as immune checkpoints
The symbiotic relationship between the gut microbiota and host immune system promotes homeostasis and a balanced microbial ecosystem. Read more
Development and Characterization of Hydrogel-Based Model(s) for Pancreatic Cancer
Pancreatic Ductal Adenocarcinoma (PDAC), which develops from cells lining pancreas ducts, represents 95% of all pancreatic cancer cases. Read more
Mapping CD4+ T cell fate decisions and functional coordination within tissues during infection
CD4+ T cells are essential components of the immune system, orchestrating protection against infection. Read more
Understanding how to target the T cell compartment within related brain tumours
T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more
The impact of nutritional scavenging on host-pathogen interactions, antifungal efficacy and emergence of antifungal resistance
Infections caused by Aspergillus fumigatus (Af) cause more deaths globally than any other fungal disease. Over 20 million are affected annually with four million having life threatening invasive and chronic infections with high morbidity and mortality up to 90%. Read more
Using a new translational in vivo model to understand the neurobiology underlying ADHD subtypes
Summary. In mice and humans loss-of-function of the steroid sulfatase (STS) enzyme results in inattention but enhanced motor response inhibition; we aim to understand the neurobiology underlying this dissociation using a new mouse model. Read more
Optoelectronic neural probes for in vivo manipulation of neural circuits
Optogenetics has become a powerful tool in neuroscience to study cortical circuit function. It relies on light sensitive proteins (opsins) that act as light switches, turning on or off specific populations of neurons in the brain. Read more