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x-ray crystallography PhD Projects, Programs & Scholarships

We have 67 x-ray crystallography PhD Projects, Programs & Scholarships

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  MRC DiMeN DTP: Dissecting INPP5K function: cell biology, structural determination by X-ray crystallography and enzymology of a key protein implicated in muscular dystrophy, insulin signalling, spastic paraplegias and Parkinsonism
  Dr L Swan, Dr S Antonyuk, Dr M Stagi
Application Deadline: 21 January 2019
The Swan laboratory (https://www.researchgate.net/profile/Laura_Swan), specialists in phosphoinositide lipid biology and the cell biology of membrane trafficking, in collaboration with international teams of clinicians and scientists, have recently discovered that mutations in a specific phosphatase cause a congenital muscular dystrophy with short stature, brain and eye manifestations (papers.
  The molecular structure and function of the synaptonemal complex in chromosome synapsis and recombination during meiosis
  Dr O Davies
Application Deadline: 11 January 2019
Meiosis, the process of reductive cell division, is essential for fertility and genetic diversity in all sexually reproducing organisms.
  Structural Studies on the Killing of Bacterial Prey by the Predatory Bacterium Bdellovibrio bacteriovorus
  Dr A Lovering
Applications accepted all year round
Bdellovibrio bacteriovorus is a small predatory bacterium able to invade and kill many different Gram-negative bacterial prey (including human, animal and crop pathogens; e.g.
  Structure and Function Studies on Proteins from Predatory Bacteria
  Dr A Lovering
Applications accepted all year round
Bdellovibrio bacteriovorus is a small predatory bacterium able to invade and kill many different Gram-negative bacterial prey (including human, animal and crop pathogens; e.g.
  Structure studies of centrosomal and ciliary proteins to understand the molecular mechanisms of ciliopathies
  Research Group: School of Molecular and Cellular Biology
  Dr T Ochi
Application Deadline: 17 December 2018
The aim of this PhD project is to determine the molecular assembly mechanism of a structure of the centriole / basal body by a combined approach of structure biology (cryo-EM and X-ray crystallography) and biochemistry in order to understand underlying mechanisms that cause ciliopathies and cancer.
  MRC DiMeN Doctoral Training Partnership: Breaking up the fight: Defining the spatial requirements for therapeutic modulation of signalling through FcγRIIa
  Dr j Robinson, Prof A Morgan, Prof A Goldman, Dr M E Webb
Application Deadline: 21 January 2019
Autoantibody-mediated inflammatory diseases are characterised by a proinflammatory feedback loop which leads to the destruction of tissues, prolonged pain, fatigue and subsequent reduction in life quality.
  Iron acquisition using host lactoferrin by the bacterial pathogen Campylobacter jejuni
  Prof J Ketley, Dr J Morrissey
Application Deadline: 6 January 2019
Campylobacter jejuni is the main cause of bacterial food-borne disease in the UK and is a global public health priority. Infection and transmission are usually linked with contaminated food or water, with chicken being a major source.
  Structural investigation of Sam68-driven transcription/splicing coupling
  Dr C Dominguez, Prof I C Eperon
Application Deadline: 6 January 2019
The identification of 20-25,000 human genes by the human genome project came as a big surprise since the estimated number of human proteins is around 130,000.
  Bacteriophages of Gram positive bacteria: gateways to infection control
  Dr G Xia, Prof J P Derrick
Applications accepted all year round
The rise in antibiotic resistance has prompted a renewed interest in bacteriophage research. A study of the molecular basis for recognition of the bacterial host has applications in detection, vaccine design and control of bacterial infections.
  Structure and function of key ABC Transporters in health and disease
  Prof L Carpenter, Dr H de Wet
Application Deadline: 25 January 2019
Human ABC transporters are a family 52 integral membrane proteins that transport diverse molecules across cell membranes. Mutations in ABC transporters causes a range of diseases, including diabetes (ABCC8 and ABCC9), cystic fibrosis (ABCC7, CFTR) and blindness (ABCA4).
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