Understanding a molecular architecture of the centriole / basal body
Dr T Ochi
31 January 2019
The aim of this PhD project is to determine the molecular assembly mechanism of a structure of the centriole / basal body by a combined approach of structure biology (cryo-EM and X-ray crystallography) and biochemistry in order to understand underlying mechanisms that cause ciliopathies and cancer.
Bacteriophages of Gram positive bacteria: gateways to infection control
Dr G Xia, Prof J P Derrick
Applications accepted all year round
The rise in antibiotic resistance has prompted a renewed interest in bacteriophage research. A study of the molecular basis for recognition of the bacterial host has applications in detection, vaccine design and control of bacterial infections.
Structure and function of key ABC Transporters in health and disease
Prof L Carpenter, Dr H de Wet
25 January 2019
Human ABC transporters are a family 52 integral membrane proteins that transport diverse molecules across cell membranes. Mutations in ABC transporters causes a range of diseases, including diabetes (ABCC8 and ABCC9), cystic fibrosis (ABCC7, CFTR) and blindness (ABCA4).