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genes PhD Projects, Programs & Scholarships

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  Genomics, gene regulation and disease: how mammalian genes are regulated and how their deregulation is linked with human disease
  Assoc Prof J Hughes, Prof T Milne
Application Deadline: 26 July 2019

Funding Type

PhD Type

The Hughes group is interested in how mammalian genes are regulated and how their deregulation is linked with human disease. The ~22 thousand genes in the mammalian genome are present in the DNA of every cell but are used in complex patterns in different cell types and organs.
  Gene Regulation: How mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseases
  Prof D Higgs, Assoc Prof J Hughes, Dr R Gibbons, Dr V Buckle
Application Deadline: 26 July 2019

Funding Type

PhD Type

Other Potential Supervisors. Mira Kassouf. Our laboratory addresses the question of how mammalian genes are switched on and off during development, lineage commitment and differentiation.
  Investigation of the role of myopia susceptibility genes in early eye development.
  Prof L Erskine, Prof N Vargesson, Prof M Collinson
Application Deadline: 28 June 2019

Funding Type

PhD Type

The aim of this project is to determine the role of inherited refractive error risk factors in the pre-birth development of the eye.
  Application of data science to inherited genetic variants of apoptosis genes and susceptibility to breast cancer
  Prof A Cox, Dr K Walters
Application Deadline: 3 July 2019

Funding Type

PhD Type

Background. The identification of the breast and ovarian cancer genes BRCA1 and BRCA2 two decades ago has resulted in both improved patient risk assessment, and the use of PARP-inhibitors for treatment.
  Genetic Epidemiology of Cardiovascular Disease: Studying genetic variation in cardiomyopathy and coronary artery disease across the entire allele frequency spectrum in order to identify causative genes and susceptibility loci.
  Prof M Farrall, Dr AG Goel
Application Deadline: 26 July 2019

Funding Type

PhD Type

Studying genetic variation in cardiomyopathy and coronary artery disease across the entire allele frequency spectrum in order to identify causative genes and susceptibility loci.
  Engineering tRNA neochromosomes in yeast
  Prof P Cai, Prof D Delneri
Applications accepted all year round

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
  Using canine models of obesity to discover the mechanisms by which genes influence obesity.
  Dr E Raffan, Dr D Sargan
Applications accepted all year round

Funding Type

PhD Type

We are interested in discovering the mechanisms by which genes influence obesity. The dog is an excellent model organism for human comparative analyses.
  To address the functional significance of circadian clock genes in regulating the “stemness” and tumorigenesis of mammary cells
  Prof C Streuli, Dr Q-J Meng
Applications accepted all year round

Funding Type

PhD Type

Circadian (24 hourly) rhythms generated by our intrinsic biological clocks play critical roles in regulating physiology and behaviour.
  Single-molecule imaging in live cell to study gene geography and the role of DNA biophysics in regulating genes
  Research Group: Physics of Life - Biological Physics and Biophysics
  Prof M Leake, Prof C Dorman
Application Deadline: 1 September 2019

Funding Type

PhD Type

Your project will address the key question of what is the importance of the physical location of genes in determining their state of activity.
  The physiological roles of the Rasd1 interactome in the central control of hydromineral homeostasis
  Prof D Murphy, Dr M Greenwood
Applications accepted all year round

Funding Type

PhD Type

The brain mechanisms responsible for osmotic stability are located in the hypothalamo-neurohypophyseal system (HNS), which consists of magnocellular neurons located in the supraoptic nucleus (SON) and paraventicular nucleus (PVN), the axons of which terminate in the posterior pituitary gland.
  Functional coronary artery disease genetics: investigating the role of the candidate gene in models of In vivo cardiovascular disease
  Dr G Douglas, Prof K Channon
Application Deadline: 26 July 2019

Funding Type

PhD Type

Despite significant advancements in its treatment coronary artery disease is the leading cause of death in both the UK and world wide, accounting for over 66,000 deaths in the UK each year.
  Identification and characterisation of novel QTLs and genes for dietary fibre in grain of bread wheat
  Dr A Lovegrove, Prof P Shewry
Application Deadline: 30 September 2019

Funding Type

PhD Type

A PhD studentship is available to identify and characterise new genes controlling the content of dietary fibre (arabinoxylan) in wheat flour.
  Social networking: Understanding promiscuity in the transfer of bacterial virulence genes
  Research Group: Institute of Infection, Immunity & Inflammation
  Prof JR Penades
Application Deadline: 1 September 2019

Funding Type

PhD Type

The development of novel multiresistant hypervirulent strains from formerly avirulent or only weakly virulent strains is dramatically fuelled by the acquisition of mobile genetic elements carrying virulence factors.
  How acquisition of antimicrobial resistance genes enhance bacterial colonisation and virulence.
  Dr J Morrissey, Prof P W Andrew, Prof J M Ketley
Applications accepted all year round

Funding Type

PhD Type

The human immune system uses antimicrobial metals as part of its defence mechanism. Excess copper is highly toxic and accumulates at sites of infection and acting within macrophages to kill engulfed pathogens.
  Novel tools for bioengineering gut anaerobes
  Dr K Scott, Dr S Shaw
Application Deadline: 28 June 2019

Funding Type

PhD Type

Bioengineering is widely used to incorporate new activities into specific bacteria, for example the industrial production of 1,3-propanediol from glycerol by Clostridium butyricum (1).
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