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  EASTBIO: Transcriptomics and Genomics of Brain Development: Identifying GLI3 and DMRTA2 Transcription Factor Target Genes in Regulation of Neural Progenitor Proliferation
  Dr T Theil, Prof S Hoppler
Application Deadline: 5 January 2020

Funding Type

PhD Type

Deanery of Biomedical Sciences. This project investigates how transcription factors control the proliferation and differentiation of neural stem cells in the developing cerebral cortex and thereby cortical growth.
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round

Funding Type

PhD Type

MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
  Post-translational regulation of transcription dynamics in plant immunity
  Research Group: Institute of Molecular Plant Sciences
  Dr S Spoel, Dr E Bayne
Application Deadline: 5 January 2020

Funding Type

PhD Type

Precise regulation of gene transcription is vital for all organisms. In eukaryotes, dynamic changes in gene transcription orchestrate cell development and cellular responses to the ever changing environment.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Biochemical analysis of the interaction of pluripotency transcription factors with RNA polymerase enzymes
  Research Group: Institute of Stem Cell Research
  Prof I Chambers
Application Deadline: 5 January 2020

Funding Type

PhD Type

Pluripotent stem cells possess the dual defining properties of self-renewal and multi-lineage differentiation potential. To retain an effective differentiation capacity, self-renewal must occur at high efficiency.
  Stopping transcription at the end of mammalian protein coding genes: How is this achieved and why does this matter
  Prof N J Proudfoot
Application Deadline: 10 January 2020

Funding Type

PhD Type

This research project will focus on my lab’s recent development of genomic methodology for nascent transcription analysis (1).
  Selective control of tRNA gene transcription by steroid receptors and BRCA1.
  Prof R J White, Dr W Brackenbury
Application Deadline: 5 January 2020

Funding Type

PhD Type

BRCA1 is an important tumour suppressor protein with roles in DNA repair. and transcription. BRCA1 binds many tRNA genes, but its role there is.
  Evolution of gene regulatory networks after gene duplication
  Research Group: Lymphocyte Development
  Prof M Merkenschlager, Dr P Sarkies
Application Deadline: 1 December 2019

Funding Type

PhD Type

Throughout evolution multicellular organisms have experienced large-scale structural alterations, in which regions of the genome or even the entire genome have been duplicated (1-7).
  Epigenetic regulation of meiotic genes by the transcription factor Hac1i
  Dr M Schroeder
Applications accepted all year round

Funding Type

PhD Type

A self-funded PhD studentship to investigate how the transcription factor Hac1i achieves epigenetic regulation of early meiotic genes is available in the group of Dr.
  Transcription factors mediating light input to the Arabidopsis circadian clock
  Dr P Devlin
Applications accepted all year round

Funding Type

PhD Type

The circadian clock is tightly tied to the light environment. Transcriptional feedback loops are able to generate a self-sustaining rhythm of approximately 24 hours which impinges on almost every aspect of physiology in higher organisms.
  (BBSRC DTP) Development of anti-cancer agents and biomarkers that target intrinsically disordered regions of transcription factors and protein kinases
  Prof J Waltho, Dr A Almond
Application Deadline: 31 January 2020

Funding Type

PhD Type

The controlled manipulation of transcription factors, protein kinases and protein phosphatases is central to improving our understanding of cellular processes and, importantly, in the development of next-generation therapeutics for a variety of cancers.
  Effects of transcription on genome stability
  Prof N J Savery
Applications accepted all year round

Funding Type

PhD Type

Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders.
  Precision Medicine DTP - Dissecting the biophysics of ocular transcription factors in vivo
  Research Group: MRC Human Genetics Unit
  Dr D Papadopoulos, Prof W Bickmore, Prof V Vukojevic
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Of the ~1,600 human TF genes, up to ~25% (~400 genes) are expected to be haploinsufficient with a plethora of them leading to developmental disorders1, underlining that transcription factor (TF) abundance (dosage) plays a major role during cell and tissue specification.
  Precision Medicine DTP - The role of transcription factors and the signaling environment in commitment of cells into the germline
  Research Group: Institute of Stem Cell Research
  Prof I Chambers, Dr T Chandra
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. In mammals, specification of the germline occurs shortly after implantation. Understanding how germ cells become specified is important both to inform the treatment of human infertility, for example through in-vitro spermatogenesis, and for the wider field of regenerative medicine.
  The role of cyclin-dependent kinases (CDKs) in transcription and cell cycle control.
  Prof C Norbury, Prof S Murphy
Application Deadline: 10 January 2020

Funding Type

PhD Type

Cyclin-dependent kinases (CDKs), including CDK1, 2, 4 and 6, act as master regulators of the cell cycle through phosphorylation of numerous protein targets (1).
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