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We have 75 transcription PhD Projects, Programmes & Scholarships

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transcription PhD Projects, Programmes & Scholarships

We have 75 transcription PhD Projects, Programmes & Scholarships

The Survivin Interactome in Health and Disease

Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more

Short and long-term genetic and behavioural consequences of traumatic brain injury in fruit flies

General background . How many fingers am I holding up? What day of the week is it? Follow my finger? These three questions are designed to test your sensory, memory and motor neural abilities following an accident; all three systems are affected by a severe deceleration of your brain. Read more

(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more

The role of NFIA fusion genes in erythroid leukaemia

It is clear that the process of haematopoietic (blood) development is ultimately coordinated by transcription factors, a view supported by the prevalence of transcription factor abnormalities found in leukaemia. Read more

Investigating the role of RNA dependent DNA repair in childhood cancer

Damage to our genetic material DNA is responsible for a wide range of human diseases including neurodegenerative diseases, haematological diseases, immune deficiencies, early ageing and cancers. Read more

The role of regulatory evolution in phage ecology

The regulation of genes crucially determines the fitness and function of all organisms. This is particularly relevant for bacteriophages, the viruses that infect bacteria, as they rely on a tightly scheduled program for a successful infection. Read more

Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis

Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development. Read more

The analysis of HIF function in DNA repair and genome stability

DNA damage is a factor that underlies many human diseases. Such damage results in mutations, and if such genetic alterations occur in tumour suppressor or proto-oncogenes it can lead to cancer. Read more

Retrotransposons in immunity

Only about 1-2% of our genome is made up of protein coding genes, the rest is non-coding and at least half of that is made up of repetitive DNA sequences known as transposable elements (TEs). Read more

Transcriptome homeostasis in cellular ageing and cancer

Project Summary. We have previously established the oncogenic mechanisms of the transcription factor FOXM1 in perturbation of genome stability (1, 2), epigenome (3, 4) and adult progenitor epithelial stem cell proliferation (5). Read more

Mechanisms controlling gene expression in hypoxia and inflammation

Oxygen is one of the most important molecules for life. Every member of the animal kingdom depends on oxygen to help metabolize its food and drive many critical processes in metabolism. Read more

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