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amyloid PhD Projects, Programs & Scholarships

We have 23 amyloid PhD Projects, Programs & Scholarships

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  An integrated approach to the study of cellular interactions with amyloid
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford
Applications accepted all year round

Funding Type

PhD Type

The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
  Mass spectrometry analysis of human tissue to characterise cleavage events resulting in amyloid deposition associated with aortic aneurysm and dissection
  Dr J Madine, Prof C E Eyers
Applications accepted all year round

Funding Type

PhD Type

The most common form of localised amyloid occurs in the aorta (aortic medial amyloid; AMA) and is estimated to occur in 97% of Caucasian people over 50.
  Investigating the links between osteoporosis & Alzheimer’s disease – effects of β-amyloid upon the mechanical set-point in bone
  Dr S McArthur, Dr SCF Rawlinson
Applications accepted all year round

Funding Type

PhD Type

Background. Individuals with Alzheimer’s disease are more likely to suffer from osteoporosis (the loss of bone mass and strength) than age-matched individuals; significantly contributing to the frailty associated with dementia.
  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
  Dr M Harte, Prof J Neill
Applications accepted all year round

Funding Type

PhD Type

Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
  Cryo-EM structural analysis of amyloid fibrils
  Prof M Fändrich, Dr M Schmidt
Applications accepted all year round

Funding Type

PhD Type

The Institute of Protein Biochemistry at Ulm University, Germany, investigates the molecular basis of amyloid diseases, such as Alzheimer’s disease and systemic amyloidosis.
  Protein Misfolding and the Molecular Basis of Alzheimer’s Disease
  Dr J Viles
Applications accepted all year round

Funding Type

PhD Type

Background. World-wide one in three people over the age of 65 will die with Alzheimer’s Disease (AD). The disease is characterised by deposits of amyloid plaques and fibrils of amyloid-beta peptide (Ab) are their main constituent.
  Characterisation of the neuronal receptor for soluble amyloid precursor protein: a route to new therapeutic targets for Alzheimer’s disease
  Prof N Hooper, Prof M J Humphries
Applications accepted all year round

Funding Type

PhD Type

Alzheimer’s disease (AD) is the commonest form of dementia for which currently there is no means of stopping or even slowing the disease.
  Inhibiting amyloid development using natural compounds: a molecular dynamics study
  Dr P Mulheran, Dr V A Ferro
Applications accepted all year round

Funding Type

PhD Type

Amyloid fibrils are highly ordered protein aggregates associated with many neurodegenerative diseases such as Alzheimer’s. Flavanoids, which are polyphenols such as curcumin present in the human diet, have been shown to inhibit fibril formation in tau protein which is abundant in neurons.
  Screening of chemical libraries using iPS models for investigating the role of prion protein in Alzheimer’s disease
  Prof B Chen
Applications accepted all year round

Funding Type

PhD Type

Background. AD has been identified as a protein misfolding disease (proteopathy). The disease is caused by accumulation of two major amyloids.
  The molecular basis of a genetic susceptibility gene in Alzheimer’s disease: the case of cystatin C
  Dr R Staniforth
Applications accepted all year round

Funding Type

PhD Type

Degenerative diseases associated with ageing occur sporadically and are associated with the misfolding and aggregation of a number of proteins in vivo.
  Investigating phenotypic, proteomic and functional changes in microglia in a preclinical model for sporadic Alzheimer’s disease research (Manchester-Melbourne Dual Award)
  Dr M Harte, Dr A Tirella
Application Deadline: 31 January 2020

Funding Type

PhD Type

Current treatments for Alzheimer’s disease (AD) are symptomatic and do little to slow down the progression of the disease. This has led to an array of research investigating hallmark pathologies in the search for novel therapeutic strategies.
  Ca2+ signalling in neurodegeneration and Alzheimer’s disease
  Research Group: School of Biology
  Prof I A Hope
Applications accepted all year round

Funding Type

PhD Type

Human variants of the ryanodine receptor, the main intracellular calcium ion channel, could be responsible for Alzheimer’s disease.
  Roles of post-translational modifications in neurodegenerative protein aggregation
  Dr F Aprile
Application Deadline: 29 February 2020

Funding Type

PhD Type

A fully funded PhD studentship position is available in the Aprile group in the Department of Chemistry at the White City Campus of Imperial College London.
  Are Tau fibrils induced by phosphorylation and the interaction with 14-3-3 proteins relevant for Alzheimer disease?
  Dr J Hritz, Dr JN Nováček, Dr J Pribyl
Application Deadline: 20 February 2020

Funding Type

PhD Type

Several neurodegenerative diseases are associated with the formation of fibrous protein aggregates. The fibrillization of amyloid beta peptide into amyloid plaques and the agregation of hyperphosphorylated tau protein into neurofibrillar tangles are main neuropatological signs of Alzheimer disease.
  Investigating the molecular mechanisms and consequences of ANP aggregation for cardiovascular disease; a computational and experimental approach
  Dr J Madine, Dr D J Rigden, Dr M Winn
Applications accepted all year round

Funding Type

PhD Type

Atrial natriuretic peptide (ANP) is a cardiovascular hormone synthesised and secreted by myocytes in the atrial wall where it regulates atrial blood volume and vasodilation.
  Role of phosphorylated 14-3-3 proteins
  Dr J Hritz, Assoc Prof V Bryja
Application Deadline: 1 February 2020

Funding Type

PhD Type

14-3-3 proteins play key role in the neurobiochemistry of brain and are also associated with neurodegenerative amyloid diseases such as Alzheimer and Parkinson disease.
  The role of SORL1 in B cell antigen trafficking
  Research Group: Centre for Experimental Medicine
  Dr D Malinova, Dr A Kissenpfennig
Application Deadline: 20 January 2020

Funding Type

PhD Type

B cells are a crucial element of adaptive immunity by producing antibodies to neutralise invading pathogens. For an effective antibody response, a B cell must interact with and internalise (endocytose) antigens through its surface B cell receptor.
  (BBSRC DTP) Selective knockdown of proinflammatory microRNAs to tackle neurodegeneration and cognitive decline: myth or reality?
  Dr E Bichenkova, Prof J Neill, Dr F Roncaroli, Prof D Clarke
Application Deadline: 31 January 2020

Funding Type

PhD Type

Neurodegenerative diseases (e.g. multiple and amyotrophic lateral sclerosis, Alzheimer’s and Parkinson’s diseases) have tremendous psychological, clinical and social impact, which becomes increasingly challenging in the global trend of population aging.
  Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
  Dr J L Penny, Dr C Demonacos
Applications accepted all year round

Funding Type

PhD Type

In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.
  Understanding cellular and network mechanisms underlying memory dysfunction in Alzheimer’s disease
  Research Group: Centre for Clinical Brain Sciences
  Dr S Wang, Prof S Grant
Application Deadline: 29 February 2020

Funding Type

PhD Type

Memory impairment is among the early signs in Alzheimer’s disease (AD) that significantly affects daily function. It is vital to understand how neurons encoding memory (i.e.
  A novel human 3D in vitro dynamic model with integrated sensors for studying neurovasculature inflammation
  Dr V Pensabene, Dr S Saha
Application Deadline: 30 April 2020

Funding Type

PhD Type

The brain microvasculature is composed of endothelial cells, pericytes and astrocytes. The endothelium forms the barrier between the blood and the brain cells (i.e “blood-brain barrier “, BBB).
  Bioactive Peptide Nanostructures: The relation between bioactivity and molecular self-assembly into diverse nanostructures
  Prof I W Hamley
Applications accepted all year round

Funding Type

PhD Type

Research into bioactive peptides includes work on antimicrobial peptides, amyloid-related peptides with relevance to protein misfolding diseases such as Alzheimers, lipopeptides with applications in immune therapies and for wound healing and skincare.
  Advanced Optical Techniques to Unveil the Molecular Nanoworld of Alzheimer’s Disease
  Research Group: Physics of Life - Biological Physics and Biophysics
  Dr S Quinn, Prof M Leake
Application Deadline: 21 February 2020

Funding Type

PhD Type

The devastating failure of Alzheimer’s disease (AD) therapies indicates a lack of mechanistic understanding of its pathogenesis. While major hallmarks of AD include aggregates of the amyloid beta protein (A-beta) and dysregulation of vital cellular contents, key gaps in our knowledge remain.
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