Imperial College London Featured PhD Programmes
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career PhD Projects, Programs & Scholarships

We have 721 career PhD Projects, Programs & Scholarships

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  Detecting Schistisome Infection in Biomphalaria and Bulinus Snails
  Dr C M Wade, Dr S Goodacre
Applications accepted all year round

Funding Type

PhD Type

Schistosomiasis (bilharzia) is a neglected tropical disease that affects some 252 million people worldwide. It is caused by parasitic flatworms of the genus Schistosoma and is contracted through human contact with contaminated water.
  Discovering new DNA repair enzymes using archaea as a model for mammals
  Dr E Bolt, Dr T Allers
Applications accepted all year round

Funding Type

PhD Type

This PhD research project will combine protein biochemistry and molecular biology methods, and will provide detailed training into how to analyse gene and protein function.
  DNA replication, recombination and repair in Archaea
  Dr T Allers, Dr E Bolt
Applications accepted all year round

Funding Type

PhD Type

Additional Supervisor. Anita Marchfelder (University of Ulm, Germany). Archaea are the third domain of life, alongside eukaryotes and bacteria.
  Enzymes of endocannabinoid turnover in inflammatory responses
  Dr SPH Alexander
Applications accepted all year round

Funding Type

PhD Type

Over recent years, we have generated, developed and established a wide range of assays for different enzyme activities.
  Exploring relationships between Wild house mouse ecology and immunology
  Prof J Bradley
Applications accepted all year round

Funding Type

PhD Type

Understanding the causes of variability in the immune systems response underpins our knowledge of disease susceptibility, control of infectious diseases and ultimately, healthy aging.
  Functional characterization of Neisserial toxin-antitoxin systems
  Dr N Oldfield, Dr D Turner
Applications accepted all year round

Funding Type

PhD Type

Toxin-antitoxin (TA) systems are commonly found in both Gram-positive and Gram-negative bacteria and comprise a stable toxin able to stall bacterial replication and an antitoxin that neutralises the activity of the toxin.
  Hydrogen sulphide as a treatment for respiratory disease.
  Dr R Roberts, Dr SPH Alexander
Applications accepted all year round

Funding Type

PhD Type

We have demonstrated that hydrogen sulphide (H2S) is synthesised within the airways in the lungs. H2S synthesis in the airways occurs through activation of the enzymes cystathionine  lyase, cystathionine β synthase, and mercaptopyruvate sulphurtransferase (MPST).
  Mechanisms behind fetal vascular dysfunction in diabetic pregnancies
  Dr L Leach
Applications accepted all year round

Funding Type

PhD Type

The central research focus of our group is to understand the mechanisms regulating two key functions of human blood vessels. permeability and angiogenesis.
  Mechanisms of neuronal protection in diabetic neuropathy.
  Dr L Donaldson
Applications accepted all year round

Funding Type

PhD Type

Sensory neurons are particularly vulnerable to damage. This is now most commonly found in diabetes mellitus where hyperglycaemia results in the production of several factors (e.g.
  Natural toxins and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides
  Dr I R Mellor
Applications accepted all year round

Funding Type

PhD Type

The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural toxins and their synthetic analogues act on ion channels in the nervous system.
  Pyocins as alternatives to antibiotics against Pseudomonas aeruginosa infections
  Dr C Penfold
Applications accepted all year round

Funding Type

PhD Type

Pyocins are bacteriocins produced by Pseudomonas aeruginosa to kill closely related strains of the same species during times of environmental stress.
  Regulation of clostridial solvent production by quorum sensing
  Dr K Winzer, Dr Y Zhang
Applications accepted all year round

Funding Type

PhD Type

Background. The genus Clostridium comprises a large group of strictly anaerobic and metabolically diverse spore-forming bacteria.
  Role of lipids in regulating in vivo chemotaxis
  Dr A Renault
Applications accepted all year round

Funding Type

PhD Type

Aberrant cell migration is a critical factor in the progression of many diseases including cancer and atherosclerosis.
  Sequence variation and epigenomic mechanisms underlying human neuropsychiatric and neurodegenerative diseases
  Dr HM Knight
Applications accepted all year round

Funding Type

PhD Type

This is the decade of the ‘brain’ and this is also the decade of advancements in ‘genomic technologies’. This project aims to use cutting edge sequencing technologies to understand susceptibility to human disorders of the brain.
  Tackling the fungal threat to global food security
  Prof S Avery, Dr M Brock
Applications accepted all year round

Funding Type

PhD Type

Fungi cause diseases of crops and spoilage of foods that cause losses of up to a third of food yield. This is a major global challenge given the world’s growing population and need for more food, while climate change is predicted to limit food supply in the future.
  The analysis of genetic and environmental contributions to the risk of congenital heart disease
  Dr S Loughna, Prof J D Brook
Applications accepted all year round

Funding Type

PhD Type

According to BHF statistics 12 babies are born with heart defects in the UK each day and more cases. are diagnosed in later life.
  The impact of pain on the aging nervous system
  Dr G Hathway
Applications accepted all year round

Funding Type

PhD Type

The way in which pain is detected and processed changes significantly over the life-course.
  The molecular mechanisms of organelle transport by motor protein myosin-V
  Dr A Hume
Applications accepted all year round

Funding Type

PhD Type

Organelle transport is essential for cellular function and survival, and these processes are disrupted in many common diseases including cancer, diabetes and Alzheimer’s disease.
  To experimentally determine the environmental influences acting on P. aeruginosa virulence factor expression in biofilms and understand the catalytic mechanism of one of them (the surface tethered aminopeptidase AaaA)
  Dr K Hardie
Applications accepted all year round

Funding Type

PhD Type

Pseudomonas aeruginosa is an important opportunistic pathogen. It is a problem for the immunocompromised and has attained superbug notoriety since it is evident in hospitals and has inherent resistance to antibiotics.
  Understanding structure and drug binding in the multidrug pump ABCG2
  Dr I Kerr, Dr R Layfield
Applications accepted all year round

Funding Type

PhD Type

ABCG2 is one of three human ATP binding cassette transporters that are functionally capable of exporting a diverse range of substrates from cells.
  Modelling ocean wave dissipation through pancake ice fields
  Dr F Montiel, Dr A Suanda
Applications accepted all year round

Funding Type

PhD Type

In a warming climate, ocean wave activity is projected to intensify in the polar regions. Sea ice forms as pancake ice at the ocean surface under intense wave conditions.
  Academic Endocrine Unit: investigating the molecular basis of endocrine and metabolic disorders that principally affect calcium and phosphate homeostasis.
  Prof R Thakker, Dr K Lines, Dr M Stevenson, Dr K Kooblall
Application Deadline: 24 July 2020

Funding Type

PhD Type

Other Potential Supervisors. Dr Asha Bayliss. The Academic Endocrine Unit investigates the molecular basis of endocrine and metabolic disorders that principally affect calcium and phosphate homeostasis.
  Building the skull – normal and abnormal development
  Prof A Wilkie, Dr S Twigg
Application Deadline: 24 July 2020

Funding Type

PhD Type

Using a combination of patient samples and mouse models, we study the causes and developmental origins of skull malformation. The work ranges from scanning human genome sequences for new mutations, to use of genome editing and single cell transcriptomics to model the developmental causes of these malformations in mice.
  Cardiac energetics and integrative physiology: Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.
  Prof C Lygate, Dr S Zervou
Application Deadline: 24 July 2020

Funding Type

PhD Type

Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.
  Chromatin remodelling in health and disease
  Dr R Gibbons, Prof D Higgs
Application Deadline: 24 July 2020

Funding Type

PhD Type

It has become apparent that the regulation of chromatin structure is of paramount importance in a wide variety of fundamental nuclear processes including gene expression, DNA replication, repair and recombination.
  Circadian control of energy metabolism and inflammation
  Prof D Ray
Application Deadline: 24 July 2020

Funding Type

PhD Type

Employing a range of approaches to address the physiological importance of the circadian:nuclear receptor system, ranging from population genetics, Circadian mechanisms regulate most mammalian physiology, with particular importance in the regulation of innate immunity, through the macrophage in particular, and energy metabolism, regulating liver, adipose and muscle.
  Computational Functional Genomics
  Assoc Prof G Lunter
Application Deadline: 24 July 2020

Funding Type

PhD Type

We are interested in building computational models to understand and predict the functional consequences of mutations in the (human) genome.
  De Novo Mutations and Human Disease
  Prof A Goriely, Prof A Wilkie
Application Deadline: 24 July 2020

Funding Type

PhD Type

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
  Development of the hematopoietic/ immune system in the embryo
  Prof M DeBruijn
Application Deadline: 24 July 2020

Funding Type

PhD Type

Our aim is to obtain a mechanistic insight into the birth of hematopoietic stem and progenitor cells in embryonic development and determine the contribution of these cells to the emerging hematopoietic and immune systems of the embryo.
  Functional coronary artery disease genetics - Defining the function of new causal atherosclerosis genes from CAD GWAS loci using in vitro and in vivo models
  Dr G Douglas, Prof K Channon
Application Deadline: 24 July 2020

Funding Type

PhD Type

Despite significant advancements in its treatment coronary artery disease is the leading cause of death in both the UK and world wide, accounting for over 66,000 deaths in the UK each year.
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