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We have 34 elisa PhD Projects, Programmes & Scholarships

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elisa PhD Projects, Programmes & Scholarships

We have 34 elisa PhD Projects, Programmes & Scholarships

Wearable Sample Collection for Biosensing

Measurement of low abundance proteins is key for enabling early detection of diseases [1]. A widely used method for the measurement of low abundance proteins is enzyme-linked immunosorbent assay (ELISA) [2]. Read more

Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury

Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organ systems in the hope the kidney will recover. Read more

Diagnostics for FMF patients and carrier survival in pandemics

Background. Familial Mediterranean Fever (FMF) is a rare inherited genetic disease where patients acquire a mutation on the pyrin gene leading to excessive inflammasome activation and excessive inflammation. Read more

Integrating Intelligence: Smart Textiles for Retrofitting and Monitoring Cultural Heritage Buildings

3 Year self funded project. The doctoral project will complete the activities of a European Union project focused on advancing hybrid structural retrofit solutions based on smart textiles with customized structural health monitoring for masonry cultural heritage building envelopes. Read more

Role of mechanical signals in a 3D human model of alveolar differentiation

Alveolar epithelial type I (AT1) and type II (AT2) cells are essential for normal lung function following birth. Abnormal differentiation of AT1 and AT2 cells during development results in pulmonary pathology with associated neonatal mortality and long-term morbidity. Read more

Manipulation of neuroimmune responses and behaviour by infectious agents

This project is available exclusively to self-funded students who wish to commence study for a PhD in the academic year 2023/24. The project focuses on how infectious agents modify the individuals that they infect and how neuroimmune responses to infection moderate behaviour changes in warm-blooded animals and humans. Read more

Using single cell transcriptomic and blood proteomic data to understand how pancreatic cancer causes diabetes and to find ways to detect the cancer earlier

Pancreatic cancer is the deadliest of the common cancers. Five-year survival remains low at 12%. Sadly for 80% of patients, by the time their cancer is diagnosed it has spread to distant organs making them ineligible for potentially curative surgery. Read more

Investigating the metabolic link between leukaemia and heart failure (RUSHWORTHS_U24BIGC)

Primary supervisor - Dr Stuart Rushworth. Secondary supervisor - Dr James Smith. Rushworth Lab. This 4-year PhD project funded by the Big C cancer charity represents an exciting opportunity to develop and conduct research at the forefront of cancer research. Read more

SLS 3: Investigating the anti-inflammatory effects of artemisinin compounds on macrophages under systemic inflammatory conditions

Artemisinin compounds are safe and effective antimalarials. Recent evidence in our lab has shown these compounds also exert a potent anti-inflammatory effect by inhibiting neutrophil migration and the release of cytokines, chemokines and neutrophil extracellular traps. Read more

Peptide-mediated nanocarrier drug delivery for enhanced brain targeting and treatment of inflammation

This project involves the study of nanoparticles and drug delivery to the brain. The student would be required to make and characterise novel nanoparticles from special lipid molecules of various compositions more suitable for blood-brain barrier (BBB) targeting. Read more

Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more

Developing therapies targeting inflammation and dysfunctional matrix biology in neurological and ocular disease

We are seeking talented, motivated students with a passion for research in inflammation and matrix biology in the eye and brain to join our team co-led by Dr Lisa Hill https://www.birmingham.ac.uk/staff/profiles/clinical-sciences/hill-lisa.aspx and Dr Hannah Botfield https://www.birmingham.ac.uk/staff/profiles/inflammation-ageing/botfield-hannah.aspx. Read more

Effect of androgens on preantral follicle development

Polycystic ovary syndrome (PCOS) is a condition that affects >5% of women of reproductive age and is the most common cause of menstrual dysfunction and is associated with metabolic abnormalities and increased risk to long-term health. Read more

Development of molecularly imprinted polymers (MIPs) assisted analytical methods for detection and monitoring of protein/enzyme biomarkers

Biomarkers have been used prolifically in the field of medicine to provide a rapid and easy method of monitoring many normal biochemical pathways and many pathological conditions without the need for any invasive procedures [1,2]. . Read more

Antisense technologies as potential treatments for Cushing’s disease

Cushing’s disease is a devastating condition caused by a pituitary corticotroph tumour that over-expresses the proopiomelanocortin gene (POMC) and secretes high levels of ACTH. Read more

Cancer: Understanding the immunosuppressive role of fibroblast and macrophages in Breast cancer

Oncolytic viruses (OVs) preferentially infect and kill cancer cells, and their clinical efficacy has been demonstrated against a number of different cancers. The most clinically advanced OV is a genetically engineered herpes simplex virus (T-VEC) which expresses GMCSF to aid the development of anti-tumour immune responses; T-VEC is approved for the treatment of metastatic melanoma. Read more

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