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We have 16 embryonic stem cells PhD Projects, Programmes & Scholarships

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embryonic stem cells PhD Projects, Programmes & Scholarships

We have 16 embryonic stem cells PhD Projects, Programmes & Scholarships

Exploring the role of interferon stimulated genes (ISGs) in stem cells of serous ovarian cancer

  Research Group: Institute of Cancer Therapeutics
Epithelial ovarian cancer (EOC) is the leading cause of mortality in women due to gynaecological cancers. High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of patients with EOC. Read more

Deriving functional neurons from hIPSCs

Neuronal networks grown on petri dishes encode information as electrical activity. This activity is dictated by their underlying structural and functional connectivity. Read more

Uncovering the mechanochemical signalling inputs that drive gastruloid axial patterning

How the early mammalian embryo converts a mass of identical cells in an organism with multiple axes of symmetry (anteroposterior, dorsoventral, mediolateral) is a critical question in developmental biology. Read more

Stochastic modelling and inference for live-cell gene expression time-series data to unravel the mechanisms of stem cell differentiation

  Research Group: Division of Statistics
This project will develop statistical methodology for noisy time-series data and stochastic computational models to analyse live-cell imaging data provided by the lab of our collaborator Dr Cerys Manning at the University of Manchester. Read more

Engineering extracellular vesicles/exosomes for the treatment of ocular disease

Extracellular vesicles, also referred to as exosomes, are membrane‐bound particles containing huge numbers of proteins as well as genetic material in the form of RNA (mRNA and miRNA). Read more

Vascularising human mini-brains in a dish

Blood vessels play a pivotal role in brain development and function. They promote tissue growth and survival by supplying nutrients and oxygen to surrounding tissues, signals to progenitor populations, as well as guiding neuronal migration. Read more

Understanding gene regulation by HDAC1 complexes in development and cancer

Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more
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