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flow cytometry PhD Projects, Programs & Scholarships

We have 104 flow cytometry PhD Projects, Programs & Scholarships

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  An integrated approach to the study of cellular interactions with amyloid
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford
Applications accepted all year round

Funding Type

PhD Type

The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
  Enhancing Oncolytic Virus-induced Immunotherapy using Eicosapentaenoic Acid (EPA)
  Dr F Errington-Mais, Dr MA Volpato
Applications accepted all year round

Funding Type

PhD Type

Breast cancer is the most commonly diagnosed cancer in women with triple-negative breast cancer (TNBC) having the worst prognosis, highest death rate and lowest overall survival.
  Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
  Dr S Papa
Applications accepted all year round

Funding Type

PhD Type

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow.
  Molecular modelling and analysis of plasma cell cancers
  Dr R Tooze, Dr G Doody, Dr R Owen
Application Deadline: 10 March 2020

Funding Type

PhD Type

Plasma cell neoplasms, including multiple myeloma, are cancers of the immune system that remain largely incurable despite major advances in therapy.
  Personalised anti-viral immunotherapies for hepatitis B and C virus-associated hepatocellular carcinoma
  Dr A Samson, Dr S Griffin
Application Deadline: 28 February 2020

Funding Type

PhD Type

Hepatocellular carcinoma (HCC) is a cancer of hepatocytes commonly caused by hepatitis B and C virus (HBV/HCV) infections. Only 12% of HCC patients survive for five-years, due to late diagnosis and inadequate non-personalised therapies.
  Defining the role of NF-𝜅B during embryonic stem cell differentiation
  Dr D Turner, Prof A McArdle
Applications accepted all year round

Funding Type

PhD Type

Mouse Embryonic stem cells (mESCs) are a useful system to probe early development. They can be maintained in a pluripotent state in culture, and differentiated using well-defined protocols to all tissue types of the embryo proper.
  Joint PhD with University of Manchester: Identifying the mechanisms of sub-clinical corneal inflammation during contact lens wear
  Dr L Downie, Dr C Maldonado-Codina
Application Deadline: 13 March 2020

Funding Type

PhD Type

Have you ever wondered what happens to the surface of the eye when you apply a contact lens? Some people suffer from red and painful eyes with their contact lenses and many wearers suffer from discomfort at the end of each lens-wear day.
  Expression systems for pluripotent stem cells and their differentiated derivatives
  Prof E Stanley, Prof AG Elefanty
Applications accepted all year round

Funding Type

PhD Type

Human pluripotent stem cells provide an opportunity to study normal development, to model disease and to generate cells and products for therapeutic use.
  In vitro models of type 1 diabetes.
  Prof E Stanley, Prof AG Elefanty
Applications accepted all year round

Funding Type

PhD Type

Type 1 diabetes is a condition in which the immune system destroys the cells that produce insulin, the hormone controlling the level of glucose in the blood stream.
  Making B-lymphocytes form pluripotent stem cells. pervisor
  Prof E Stanley, Prof AG Elefanty
Applications accepted all year round

Funding Type

PhD Type

B lymphocytes are a critical arm of the adaptive immune system. The in vitro generation of B cells from human pluripotent stem cells provides an opportunity to study normal immune development, to model disease and to generate cells and products for potential therapeutic use.
  Modelling T-cell Development using pluripotent stem cells
  Prof E Stanley, Prof AG Elefanty
Applications accepted all year round

Funding Type

PhD Type

T lymphocytes are a critical arm of the adaptive immune system. The in vitro generation of T cells from human pluripotent stem cells provides an opportunity to study normal immune development, to model disease and to generate cells and products for therapeutic use.
  Pre-clinical investigations of POLQ inhibitors
  Dr G Higgins, Prof T Humphrey
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. The aim of our research is to improve radiotherapy for cancer patients by making tumour cells more sensitive to radiation without affecting the sensitivity of normal cells.
  The role of the AXL Receptor Tyrosine Kinase in the DNA damage response
  Prof A Giaccia, Prof E Hammond
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. The Axl receptor tyrosine kinase is a critical driver of tumour progression and drug resistance, and has resulted in combining Axl inhibitors with both targeted and cytotoxic therapies.
  Defining protein degradation machinery in the endoplasmic reticulum underlying resistance mechanisms in cancer
  Assoc Prof J Christianson, Prof Udo Oppermann
Application Deadline: 3 March 2020

Funding Type

PhD Type

Cellular stress is a hallmark of cancers. The restorative homeostatic response mechanisms that often become constitutively engaged, serve to adapt populations to hyperproliferative and metabolically dysregulated states, stabilise malignancy, and elevate resistance to therapeutic agents.
  Academic Endocrine Unit: investigating the molecular basis of endocrine and metabolic disorders that principally affect calcium and phosphate homeostasis.
  Prof R Thakker, Dr K Lines, Dr M Stevenson, Dr K Kooblall
Application Deadline: 24 July 2020

Funding Type

PhD Type

Other Potential Supervisors. Dr Asha Bayliss. The Academic Endocrine Unit investigates the molecular basis of endocrine and metabolic disorders that principally affect calcium and phosphate homeostasis.
  Identification of key determinants affecting the quality of human Cancer specific cytotoxic T cells
  Prof T Dong
Application Deadline: 24 July 2020

Funding Type

PhD Type

The main objective of my group’s research is to focus on the functional aspects of the antigen specific T cells and study the factors affecting Cytotoxic T cells in controlling cancer development.
  Megakaryocytes, platelets and Malignant Bone Marrow Fibro
  Dr B Psalia, Prof A Mead
Application Deadline: 24 July 2020

Funding Type

PhD Type

My group focuses on the biology of megakaryocyte cells - large, rare cells found in the bone marrow that release blood platelets into the circulation and also produce many growth factors and other proteins that regulate blood cell development and the bone marrow microenvironment.
  Single Cell Biology of Hematopoietic Stem- and Progenitor Cells in Blood Cancer and Ageing
  Prof Claus Nerlov, Prof P Vyas
Application Deadline: 24 July 2020

Funding Type

PhD Type

The focus of the Nerlov laboratory is to use single cell genomics and functional analysis, combined with advanced mouse genetics, to study the function of hematopoietic stem– and progenitor cells in normal development and during ageing.
  Development and Maturation of B cell Mediated Immune Responses
  Dr O Bannard
Application Deadline: 24 July 2020

Funding Type

PhD Type

We study the cellular interactions and molecular events that lead to the development of high affinity and protective antibodies during humoral immune responses.
  Identification of key determinants affecting the quality of human Cancer specific cytotoxic T cells
  Prof T Dong
Application Deadline: 24 July 2020

Funding Type

PhD Type

The main objective of my group’s research is to focus on the functional aspects of the antigen specific T cells and study the factors affecting Cytotoxic T cells in controlling cancer development.
  Megakaryocytes, platelets and Malignant Bone Marrow Fibro
  Dr B Psalia, Prof A Mead
Application Deadline: 24 July 2020

Funding Type

PhD Type

My group focuses on the biology of megakaryocyte cells - large, rare cells found in the bone marrow that release blood platelets into the circulation and also produce many growth factors and other proteins that regulate blood cell development and the bone marrow microenvironment.
  Single Cell Biology of Hematopoietic Stem- and Progenitor Cells in Blood Cancer and Ageing
  Prof Claus Nerlov, Prof P Vyas
Application Deadline: 24 July 2020

Funding Type

PhD Type

The focus of the Nerlov laboratory is to use single cell genomics and functional analysis, combined with advanced mouse genetics, to study the function of hematopoietic stem– and progenitor cells in normal development and during ageing.
  Designing novel composite polysaccharide nanoparticles for combined diagnosis and treatment of cancers
  Dr E Barbu, Dr A Lalatsa
Applications accepted all year round

Funding Type

PhD Type

Cancer continues to impose a vast burden with regard to financial costs as well as human suffering but the progress in its treatment is hindered by the limited selectivity and significant side-effects that the current chemotherapy demonstrates, representing a major challenge for modern drug delivery.
  Cell competition as a tumour suppressor in leukaemia
  Dr C Slape
Application Deadline: 28 February 2020

Funding Type

PhD Type

Leukaemia is a devastating disease that, despite advances in treatment, still carries a poor prognosis, and as such the disease represents a huge burden on the health care system.
  FoodBioSystems DTP - Diet and Chronic Disease: mechanistic studies on the impact of dietary protein on gut barrier function and the microbiota.
  Dr M Lewis, Dr D Robertson, Prof B A Griffin, Dr G Walton
Application Deadline: 6 March 2020

Funding Type

PhD Type

Research Group. FOODBIOSYSTEMS BBSRC DTP. The gut microbiota is increasingly being linked to various chronic diseases including cardiovascular and liver disease.
  Biological role of neuropeptides and their receptors
  Dr L Lander
Applications accepted all year round

Funding Type

PhD Type

"Cell signalling is critical to the co-ordination and functioning of all cells. Cell signalling allows cells to co-ordinate activities within the intracellular environment as well as ensuring cells know how to correctly respond to other cells and to an ever-changing extracellular environment as well.
  Platelet-cell interactions: Platelets beyond thrombosis and haemostasis
  Dr A Pollitt
Applications accepted all year round

Funding Type

PhD Type

"Platelets play a key role in the prevention of bleeding following blood vessel damage.
  Using CRISPR in iPS cells to modify platelet function
  Dr C.E. Hughes
Applications accepted all year round

Funding Type

PhD Type

"Platelets are the small cells in the blood whose job it is to prevent bleeding. Under normal conditions, when they encounter a damaged blood vessel they become activated and form a thrombus.
  The evolution of symbiosis - testing the evolutionary theory of ecological conditions driving the emergence of symbioses
  Prof M Brockhurst
Applications accepted all year round

Funding Type

PhD Type

Symbiosis allows organisms to gain novel functions and exploit new ecological niches through the merger of once independent species.
  Characterisation of the genotype and phenotype of epithelial cells invaded by the periodontal pathogen Porphyromonas gingivalis.
  Dr S Whawell, Dr G Stafford
Applications accepted all year round

Funding Type

PhD Type

The presence of the Gram negative anaerobe Porphyromonas gingivalis is consistently associated with the more severe forms of periodontal disease and its ability to invade host epithelial cells is thought to be important in the pathogenesis of the disease.
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