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genes PhD Projects, Programs & Scholarships

We have 191 genes PhD Projects, Programs & Scholarships

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  Genomics, gene regulation and disease: how mammalian genes are regulated and how their deregulation is linked with human disease
  Assoc Prof J Hughes, Prof T Milne
Application Deadline: 26 July 2019

Funding Type

PhD Type

The Hughes group is interested in how mammalian genes are regulated and how their deregulation is linked with human disease. The ~22 thousand genes in the mammalian genome are present in the DNA of every cell but are used in complex patterns in different cell types and organs.
  Gene Regulation: How mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseases
  Prof D Higgs, Assoc Prof J Hughes, Dr R Gibbons, Dr V Buckle
Application Deadline: 26 July 2019

Funding Type

PhD Type

Other Potential Supervisors. Mira Kassouf. Our laboratory addresses the question of how mammalian genes are switched on and off during development, lineage commitment and differentiation.
  Identification and functional characterisation of BRIT1/MCPH1 synthetic lethal genes to treat breast and ovarian cancer
  Dr S Bell, Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Women who have undergone surgery for breast and ovarian cancer often have additional chemotherapy to kill residual cancer cells and prevent recurrence.
  Investigating the candidate genes that alter body fat distribution using a big data analysis and CRISPR-Cas9 gene editing
  Dr A Oguro-Ando
Application Deadline: 27 May 2019

Funding Type

PhD Type

Lead supervisor. Dr Asami Oguro-Ando, College of Medicine and Health, University of Exeter. Additional supervisors. Prof Tim Frayling, College of Medicine and Health, University of Exeter.
  Genetic Epidemiology of Cardiovascular Disease: Studying genetic variation in cardiomyopathy and coronary artery disease across the entire allele frequency spectrum in order to identify causative genes and susceptibility loci.
  Prof M Farrall, Dr AG Goel
Application Deadline: 26 July 2019

Funding Type

PhD Type

Studying genetic variation in cardiomyopathy and coronary artery disease across the entire allele frequency spectrum in order to identify causative genes and susceptibility loci.
  Using canine models of obesity to discover the mechanisms by which genes influence obesity.
  Dr E Raffan, Dr D Sargan
Applications accepted all year round

Funding Type

PhD Type

We are interested in discovering the mechanisms by which genes influence obesity. The dog is an excellent model organism for human comparative analyses.
  To address the functional significance of circadian clock genes in regulating the “stemness” and tumorigenesis of mammary cells
  Prof C Streuli, Dr Q-J Meng
Applications accepted all year round

Funding Type

PhD Type

Circadian (24 hourly) rhythms generated by our intrinsic biological clocks play critical roles in regulating physiology and behaviour.
  Single-molecule imaging in live cell to study gene geography and the role of DNA biophysics in regulating genes
  Research Group: Physics of Life - Biological Physics and Biophysics
  Prof M Leake, Prof C Dorman
Application Deadline: 1 September 2019

Funding Type

PhD Type

Your project will address the key question of what is the importance of the physical location of genes in determining their state of activity.
  The physiological roles of the Rasd1 interactome in the central control of hydromineral homeostasis
  Prof D Murphy, Dr M Greenwood
Applications accepted all year round

Funding Type

PhD Type

The brain mechanisms responsible for osmotic stability are located in the hypothalamo-neurohypophyseal system (HNS), which consists of magnocellular neurons located in the supraoptic nucleus (SON) and paraventicular nucleus (PVN), the axons of which terminate in the posterior pituitary gland.
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
  Functional coronary artery disease genetics: investigating the role of the candidate gene in models of In vivo cardiovascular disease
  Dr G Douglas, Prof K Channon
Application Deadline: 26 July 2019

Funding Type

PhD Type

Despite significant advancements in its treatment coronary artery disease is the leading cause of death in both the UK and world wide, accounting for over 66,000 deaths in the UK each year.
  Social networking: Understanding promiscuity in the transfer of bacterial virulence genes
  Research Group: Institute of Infection, Immunity & Inflammation
  Prof JR Penades
Application Deadline: 1 September 2019

Funding Type

PhD Type

The development of novel multiresistant hypervirulent strains from formerly avirulent or only weakly virulent strains is dramatically fuelled by the acquisition of mobile genetic elements carrying virulence factors.
  An intelligent scheme to identify novel drug targets through analysing the DNA repairome in drug resistant cancer?
  Research Group: Biomedical Research Group
  Prof C Parris
Applications accepted all year round

Funding Type

PhD Type

Research Group. Biomedical Research Group. https://www.anglia.ac.uk/science-and-engineering/research/institutes-and-groups/biomedical.
  Identifying the genetic determinants of translation rate in blood cells and characterising their relevance to human traits
  Dr E Turro, Dr W Astle, Dr M Frontini
Application Deadline: 31 May 2019

Funding Type

PhD Type

The central dogma of molecular biology states that genetically encoded information flows from DNA to mRNA to protein. The flow from DNA to mRNA occurs through a process called transcription and the flow from mRNA to protein through a process called translation.
  Interneuron Development in the Zebrafish Spinal Cord
  Dr K Lewis
Applications accepted all year round

Funding Type

PhD Type

The Lewis Lab moved to Syracuse University from Cambridge University in the UK in 2010.
  Investigating convergent pathways regulating pancreatic and brain development in humans.
  Dr A Bhinge
Application Deadline: 27 May 2019

Funding Type

PhD Type

Lead supervisor. Dr Akshay Bhinge, College of Medicine and Health, University of Exeter. Additional supervisors. Professor Andrew Hattersley, College of Medicine and Health, University of Exeter.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  Characterization and functional analysis of a novel cancer-associated gene
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

In order to identify new candidate cancer-related genes, our lab developed a bioinformatics “guilt-by-association” method to identify and rank genes that are co-expressed with known cancer-related genes.
  Understanding the role of HoxA9 in chemotherapy resistance of Acute Myeloid Leukaemia (AML)
  Dr M Esposito
Applications accepted all year round

Funding Type

PhD Type

Acute Myeloid Leukaemia (AML) is a rare but yet deadly form of blood cancer. Genome-wide expression arrays and RNA sequencing have contributed to unravelling the leukaemia signature genes.
  Non-coding RNA regulation of stem cells
  Dr S Brown, Dr P Gokhale
Applications accepted all year round

Funding Type

PhD Type

Stem cells have the potential to make any cell type in the Human body and are powerful tools in drug discovery (Xia and Wong, 2012).
  Moonlight activities for cyclin genes in plants (MOUBAYIDINJ18RS)
  Dr L Moubayidin
Application Deadline: 28 May 2019

Funding Type

PhD Type

The control of cell division in plant development is crucial to achieve coherent organ patterning, and bilateral and radial symmetry.
  Clinical Genetics: De Novo Mutations, Selfish Selection, Mosaicism and Human Disease - developing methods for identification of new genes/molecular pathways subject to selfish selection within the human testis
  Prof A Goriely, Prof A Wilkie
Application Deadline: 26 July 2019

Funding Type

PhD Type

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
  Functional analysis of novel genes important in the physiology and pathogenesis of the human pathogen Campylobacter jejuni
  Prof D J Kelly
Applications accepted all year round

Funding Type

PhD Type

Campylobacter jejuni and E. coli are the commonest cause of human bacterial gastroenteritis worldwide. Although pathogenic in humans, C.
  FGFR signalling in breast cancer
  Dr A Chioni
Applications accepted all year round

Funding Type

PhD Type

Growth factors are used during development to convey messages that tell cells to divide, survive, migrate and adopt a particular fate.
  Characterising temperate bacteriophages in complex microbial communities and their role in antimicrobial resistance (Ref:SF18/APP/Smith)
  Dr D Smith
Applications accepted all year round

Funding Type

PhD Type

Temperate bacteriophages have the ability to integrate into the chromosome of their target bacterium that leads to a change in the physiology of their bacterial host.
  Control of tissue growth and cancer by the Hippo pathway
  Dr K. Harvey, Dr C Poon
Applications accepted all year round

Funding Type

PhD Type

A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have drawn conclusions about gene function using indirect techniques that only allow us to infer what a gene normally does, without actually watching it work.
  Targeting addiction to a breast cancer metastasis survival pathway by inhibition of RAN GTPase
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Prof M El-Tanani, Dr S Betmouni
Applications accepted all year round

Funding Type

PhD Type

Metastatic cancer is a major global health burden. Each year, eleven million new cases of cancer are diagnosed worldwide, including 5 million cases in industrialized countries.
  How to prevent promiscuous gene regulation
  Prof M C Gambetta
Applications accepted all year round

Funding Type

PhD Type

Regulatory elements that turn genes ON or OFF are promiscuous and can act over large genomic distances. How are genes protected from unwanted regulation?.
  Seeking critical branch points in bacterial evolution with comparative genomics
  Prof N Saunders, Mr A Khan
Applications accepted all year round

Funding Type

PhD Type

This is a bioinformatics and comparative genomics-focussed project, seeking to identify the basis of speciation and sub-speciation of bacterial species accounting for the development of individual and independent lineages.
  Understanding the interplay of mutations and selection during cancer evolution
  Prof D Weghorn
Application Deadline: 23 June 2019

Funding Type

PhD Type

Cancer is a genetic disease, subject to population genetics forces like mutation, selection and stochasticity.
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