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We have 243 in vitro PhD Projects, Programmes & Scholarships

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in vitro PhD Projects, Programmes & Scholarships

We have 243 in vitro PhD Projects, Programmes & Scholarships

Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more

The impact of nutritional scavenging on host-pathogen interactions, antifungal efficacy and emergence of antifungal resistance

Infections caused by Aspergillus fumigatus (Af) cause more deaths globally than any other fungal disease. Over 20 million are affected annually with four million having life threatening invasive and chronic infections with high morbidity and mortality up to 90%. Read more

In vitro modelling and investigation of skin ageing and the impact of negative stimuli

With an ageing population and the number of over 65s predicted to be 1 in 6 by 2050 there is a real need for targeted research to enhance the quality of life of this demographic. Read more

Developing in vitro techniques to investigate host-parasite interactions in shrimps

In the heart of Asia's thriving shrimp industry lies a silent threat that undermines both economic vitality and food security. devastating diseases caused by viruses and other microbial pathogens, notably gregarine apicomplexans. Read more

Unravelling the biophysical mechanisms that regulate liver fibrosis

Applications are invited for a Postgraduate studentship, supported by the Engineering and Physical Sciences Research Council Doctoral Training Programme, to be undertaken within the College of Health and Life Sciences at Aston University. Read more

Competition and cooperation relationships within human microbial communities.

Typical studies of the human microbiome identify dysbiosis by sampling from healthy individuals, comparing them to individuals with a particular disease state, and reporting changes in the presence and/or abundance of bacterial species. Read more

Investigating the impact of inflammation on cardiovascular disease

We are seeking talented, motivated students with a passion for research in cardiovascular inflammation and immune-mediated chronic inflammatory diseases to join the group of Dr Asif Iqbal (Dr Asif Iqbal - Institute of Cardiovascular Sciences - University of Birmingham). Read more

Microfluidic technologies applied to respiratory diseases

Subject area. 3D Printing, lab-on-a-chip, Drug Delivery, Pharmaceutical Technology. In Preclinical studies, a large number of molecules and biomolecules, in a very short time, have to be evaluated in terms of efficacy and toxicity. Read more

Vascularising human mini-brains in a dish

Blood vessels play a pivotal role in brain development and function. They promote tissue growth and survival by supplying nutrients and oxygen to surrounding tissues, signals to progenitor populations, as well as guiding neuronal migration. Read more

Role of mechanical signals in a 3D human model of alveolar differentiation

Alveolar epithelial type I (AT1) and type II (AT2) cells are essential for normal lung function following birth. Abnormal differentiation of AT1 and AT2 cells during development results in pulmonary pathology with associated neonatal mortality and long-term morbidity. Read more

Dysfunctional antifungal potency of the respiratory mucosa in COPD

Inhalation of Aspergillus fumigatus spores cause >3,000,000 chronic and >200,000 invasive diseases annually worldwide. Invasive aspergillosis carries a 50% mortality rate overall, but mortality rate approaches 100% if diagnosis is delayed or missed and it is >75% in certain cohorts of patients, such as COPD sufferers. Read more

Sensitizing AML cells to RAR and VDR ligands (vitamin A and D derivatives) to prevent leukaemia relapse

The doctoral candidate (DC) will perform basic research on leukaemia cell biology in vitro and in vivo at the Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel. Read more

Investigating the mechanisms for cardiac fibrosis development and reversal

Research interests/description of main research theme. Fibrosis is a hard to treat condition of major socioeconomic importance, with ~45% of all deaths in the developed world being attributed to some type of chronic fibro-proliferative disease and is exemplified by heart disease. Read more

Molecular mechanisms underlying the anti-atherogenic actions of natural products

Atherosclerosis, the underlying cause of myocardial infarction, stroke and peripheral vascular disease, is responsible for most deaths in the western world with mortality increasing at a marked rate in developing. Read more

Investigating the innate immune response in RSV and HMPV infection

This is a Self-Funded/Sponsored PhD opportunity. FUNDING REQUIRED. Full UK/EU or International Tuition Fees. UK Living Expenses. Bench Fees (£46,000 total). Read more

Cardiac Harmony: Modelling Heart Beats with Stem Cells and Code

Despite significant advancements in cardiac research, heart disease remains a leading cause of mortality globally. Unexpected cardiac events can occur even in young, fit individuals engaged in routine activities. Read more

The Role of Reactive Sulfur Species in the Ageing Heart

Second Supervisor. Prof Melanie Madhani, University of Birmingham. Background . Ageing is a natural and complex biological process that involves the gradual deterioration of cells, tissues, and organ systems over time, thus leading to an increased susceptibility to diseases and mortality. Read more

Developing therapies targeting inflammation and dysfunctional matrix biology in neurological and ocular disease

We are seeking talented, motivated students with a passion for research in inflammation and matrix biology in the eye and brain to join our team co-led by Dr Lisa Hill https://www.birmingham.ac.uk/staff/profiles/clinical-sciences/hill-lisa.aspx and Dr Hannah Botfield https://www.birmingham.ac.uk/staff/profiles/inflammation-ageing/botfield-hannah.aspx. Read more

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