inhibitor PhD Projects, Programmes & Scholarships

Identifying Mechanisms of Tyrosine Kinase Inhibitor Resistance in Breast/Cervical Cancer (with emphasis on FGFR)

Kingston University Faculty of Health, Science, Social Care and Education

FGF signalling is implicated in cancer (e.g., breast and cervical cancer) susceptibility and progression, suggesting that this powerful developmental pathway is co-opted by cancer cells. Read more

Supervisor: Dr A Chioni

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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The role of vitamin D3 in treating skin cancer and preventing drug resistance

University of Bradford Faculty of Life Sciences

Research Group: Chemistry and Biosciences

During the last decade numerous studies have alluded to vitamin D. 3. playing a role in the prevention of cancer. Recent clinical trials looking at the potential role of vitamin D. Read more

Supervisors: Dr M Sutherland, Dr H Sheldrake, Dr S Kauser

Year round applications PhD Research Project Self-Funded PhD Students Only

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Preclinical testing of collagen synthesis inhibitors for fibrotic disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more

Supervisor: Dr EG Laird

Year round applications PhD Research Project Self-Funded PhD Students Only

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Urokinase-plasminogen activator as a target to block osteoarthritic cartilage destruction

University of Liverpool Institute of Life Course and Medical Sciences

Osteoarthritis (OA) is one of the major causes of disability globally, which is particularly significant in an ageing population. Read more

Supervisor: Dr D Wilkinson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Role of mechanical signals in a 3D human model of alveolar differentiation

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Alveolar epithelial type I (AT1) and type II (AT2) cells are essential for normal lung function following birth. Abnormal differentiation of AT1 and AT2 cells during development results in pulmonary pathology with associated neonatal mortality and long-term morbidity. Read more

Supervisors: Dr S Loukogeorgakis, Dr F Michielin, Prof P De Coppi

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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MSc By Research: Can PTP1B inhibition rewire macrophage function to improve anti-tumour immunity in breast cancer treatment?

Aberdeen University School of Medicine, Medical Sciences & Nutrition

The MSc by Research programme at the University of Aberdeen is for students interested in a research-intensive master's degree. It is designed specifically to enhance your skills for a PhD or research career. Read more

Supervisors: Prof H Wilson, Prof M Delibegovic, Prof V Speirs

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigation of novel protease-antiprotease imbalances associated with cystic fibrosis and the effect of CFTR correction.

Queen’s University Belfast School of Pharmacy

Cystic fibrosis (CF) is a progressive life-limiting airways disease that affects over 162,000 people worldwide. Read more

Supervisor: Prof L Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Selective targeting of furin for the treatment of fibrotic lung disease.

Queen’s University Belfast School of Pharmacy

Furin, a proprotein convertase has been established as a therapeutic target across several disease areas to include chronic airways diseases and infectious disease, such as COVID-19 (reviewed in our recent publication, Douglas et al, 2023). Read more

Supervisor: Prof L Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Molecular Glues as Novel Tools for Tackling Big Challenges in Human Health

University of Leicester Department of Chemistry

Background. The need for new medicines is greater than ever because of an ageing population and the complex clinical challenges brought about by drug resistance and/or side effects. Read more

Supervisors: Dr RD Doveston, Prof S Macip

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Deciphering the effect of antibody-dependent cell phagocytosis and cytotoxicity (ADCC/ADCP) in the regulation of cross-presentation and antigen spreading in liver cancer.

University of Oxford Nuffield Department of Medicine

Primary liver cancers (hepatocellular carcinoma [HCC] and intrahepatic cholangiocarcinoma) are the fourth leading cause of malignancy-related mortality worldwide. Read more

Supervisors: Dr F Galvez-Cancino, Prof I Melero Bermejo

6 May 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Exploring the multi-organ benefits of Rapamune in relation to ageing physiology

University of Nottingham School of Life Sciences

PhD Description. Drug repurposing is an emerging avenue of research in the field of Geroscience; a field whose stated aim is to “accelerate research into the basic mechanisms driving ageing which could lead to improved clinical interventions”. Read more

Supervisor: Prof P Atherton

22 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Gaining mechanistic insights into Atrial Fibrillation: Bench to bedside approaches

University of Liverpool Department of Pharmacology and Therapeutics

Atrial fibrillation (AF) is a common arrhythmia with symptoms like irregular heart rate, palpitations, shortness of breath, tiredness, and dizziness. Read more

Supervisor: Dr RB Burton

1 July 2024 PhD Research Project Self-Funded PhD Students Only

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BARIToNE: Using Next Generation Nitrogen Sources For Producing Spring Malting Barley and its Impact on Yield and Grain Malt Quality (Project code 24B)

University of Nottingham School of Life Sciences

Supervisors. Lead supervisor. Dr John Foulkes, University of Nottingham. Second supervisor. Dr Guillermina Mendiondo, University of Nottingham. Read more

Supervisors: Dr M J Foulkes, Dr G Mendiondo, Mr S Smith

31 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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The role of eIF2Bα in the response to Integrated Stress Response (ISR) modulation in cancer

Sheffield Hallam University Biomolecular Sciences Research Centre

The Industry and Innovation Research Institute (I2Ri) draws on talents, expertise and facilities across Sheffield Hallam University. Read more

Supervisors: Dr E Allen, Dr SC Campbell

10 May 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Use of a novel conjugation approach to generate a long-acting growth hormone receptor antagonist

University of Auckland Liggins Institute

Targeting the growth hormone (GH) signalling pathway could be an effective therapeutic approach for certain types of cancer. However, a lack of access to therapeutics that target GH or the GH receptor has hindered preclinical studies in this field. Read more

Supervisors: Dr Y Wang, Dr J Perry

30 August 2024 PhD Research Project Self-Funded PhD Students Only

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Multipurpose gel formulations containing antiretroviral-loaded lactoferrin nanoparticles and antibiotics for combination HIV prevention and treatment of bacterial vaginosis

Queen’s University Belfast School of Pharmacy

This is an exemplar PhD project co-supervised by Dr. Sheiliza Carmali (School of Pharmacy) and Prof. Karl Malcolm (School or Pharmacy). Read more

Supervisors: Dr S Carmali, Prof K Malcolm

Year round applications PhD Research Project Self-Funded PhD Students Only

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Is there a Role for Activated Akt in Palatogenesis?

University of Dundee Dental School

Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more

Supervisors: Dr S. J. Jones, Dr M Islam

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

University of Nottingham School of Pharmacy

Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more

Supervisor: Dr G S Winkler

Year round applications PhD Research Project Self-Funded PhD Students Only

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Therapeutic resolution of coronavirus (COVID-19) diseases by natural products

University of Bradford Faculty of Life Sciences

Research Group: Pharmacology and Experimental Therapeutics

Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more

Supervisor: Dr T Nasim

Year round applications PhD Research Project Self-Funded PhD Students Only

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The identification of allosteric inhibitors of high value therapeutic targets

University of Sheffield School of Biosciences

This study will develop a novel approach to identify allosteric inhibitor sites on a wide variety of high-value therapeutic targets, including protein kinases, protein phosphatases and small G-proteins. Read more

Supervisor: Prof J P Waltho

Year round applications PhD Research Project Self-Funded PhD Students Only

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Biological significance, predictive value and targeting of cell surface antigens in colorectal cancer

Kingston University Faculty of Health, Science, Social Care and Education

Despite major advances in its early detection, preventive measures and therapeutic options, colorectal cancer remains one of the most commonly diagnosed cancer and a leading cause of cancer deaths worldwide. Read more

Supervisor: Dr S. K Khelwatty

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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The effect of antihypertensive drugs in the treatment of breast cancer as monotherapy and in combination with Nigella sativa

Kingston University Faculty of Health, Science, Social Care and Education

Cancer research is one of the most highly funded and research-intensive fields in laboratories. Read more

Supervisor: Dr N. W Wehida

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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MSc by Research: Deciphering the role(s) of Cdk1 during oocyte meiosis

University of Dundee School of Life Sciences

Meiosis is a specialised type of cell division that produces haploid daughter cells known as gametes that are important for sexual reproduction. Read more

Supervisor: Dr F G Pelisch

Year round applications PhD Research Project Self-Funded PhD Students Only

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Short and long-distance communication in cancer: Feedback regulation of Ras signalling in tumourigenesis and cachexia

Cardiff University Cardiff School of Biosciences

Hamaratoglu Lab studies cell-cell signalling in development and tumourigenesis. We take advantage of outstanding genetic tools in Drosophila, and use larval imaginal discs as model epithelial organs. Read more

Supervisors: Dr F Hamaratoglu, Dr C Hogan

Year round applications PhD Research Project Self-Funded PhD Students Only

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Obtaining an integrated understanding of oncogenic RAS signalling

University of Leicester Molecular and Cell Biology

The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. The physiological importance of RAS signalling is evident as about 25% of all human cancers harbour mutations in ras genes, where kras is most frequently mutated (about 18%) (COSMIC, v94). Read more

Supervisor: Dr K Tanaka

Year round applications PhD Research Project Self-Funded PhD Students Only

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Antisense technologies as potential treatments for Cushing’s disease

University of Sheffield School of Medicine and Population Health

Cushing’s disease is a devastating condition caused by a pituitary corticotroph tumour that over-expresses the proopiomelanocortin gene (POMC) and secretes high levels of ACTH. Read more

Supervisor: Dr E H Kemp

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding gene regulation by HDAC1 complexes in development and cancer

University of Leicester Molecular and Cell Biology

Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more

Supervisor: Prof S Cowley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

The University of Manchester Faculty of Biology, Medicine and Health

Prostate cancer (PCa) is the commonest cancer diagnosed in men, with 5-year survival rates of 60% in those with advanced disease. Read more

Supervisors: Dr IP Monteiro dos Santos Pires, Prof AC Choudhury

Year round applications PhD Research Project Self-Funded PhD Students Only

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Regulation of gingival mast cells activity by valproic acid-potential to repurpose for treatment of periodontitis?

Queen Mary University of London Institute of Dentistry

Background. Periodontitis or chronic inflammation of the tooth-supporting tissues caused by a dysbiotic biofilm is the main cause of tooth loss in the adult population. Read more

Supervisor: Dr F Flores-Borja

Year round applications PhD Research Project Self-Funded PhD Students Only

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The Survivin Interactome in Health and Disease

University of Nottingham School of Life Sciences

Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more

Supervisor: Dr S Wheatley

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 30 inhibitor PhD Projects, Programmes & Scholarships

inhibitor PhD Projects, Programmes & Scholarships

We have 30 inhibitor PhD Projects, Programmes & Scholarships

Identifying Mechanisms of Tyrosine Kinase Inhibitor Resistance in Breast/Cervical Cancer (with emphasis on FGFR)

The role of vitamin D3 in treating skin cancer and preventing drug resistance

Preclinical testing of collagen synthesis inhibitors for fibrotic disease

Urokinase-plasminogen activator as a target to block osteoarthritic cartilage destruction

Role of mechanical signals in a 3D human model of alveolar differentiation

MSc By Research: Can PTP1B inhibition rewire macrophage function to improve anti-tumour immunity in breast cancer treatment?

Investigation of novel protease-antiprotease imbalances associated with cystic fibrosis and the effect of CFTR correction.

Selective targeting of furin for the treatment of fibrotic lung disease.

Molecular Glues as Novel Tools for Tackling Big Challenges in Human Health

Deciphering the effect of antibody-dependent cell phagocytosis and cytotoxicity (ADCC/ADCP) in the regulation of cross-presentation and antigen spreading in liver cancer.

Exploring the multi-organ benefits of Rapamune in relation to ageing physiology

Gaining mechanistic insights into Atrial Fibrillation: Bench to bedside approaches

BARIToNE: Using Next Generation Nitrogen Sources For Producing Spring Malting Barley and its Impact on Yield and Grain Malt Quality (Project code 24B)

The role of eIF2Bα in the response to Integrated Stress Response (ISR) modulation in cancer

Use of a novel conjugation approach to generate a long-acting growth hormone receptor antagonist

Multipurpose gel formulations containing antiretroviral-loaded lactoferrin nanoparticles and antibiotics for combination HIV prevention and treatment of bacterial vaginosis

Is there a Role for Activated Akt in Palatogenesis?

Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

Therapeutic resolution of coronavirus (COVID-19) diseases by natural products

The identification of allosteric inhibitors of high value therapeutic targets

Biological significance, predictive value and targeting of cell surface antigens in colorectal cancer

The effect of antihypertensive drugs in the treatment of breast cancer as monotherapy and in combination with Nigella sativa

MSc by Research: Deciphering the role(s) of Cdk1 during oocyte meiosis

Short and long-distance communication in cancer: Feedback regulation of Ras signalling in tumourigenesis and cachexia

Obtaining an integrated understanding of oncogenic RAS signalling

Antisense technologies as potential treatments for Cushing’s disease

Understanding gene regulation by HDAC1 complexes in development and cancer

Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

Regulation of gingival mast cells activity by valproic acid-potential to repurpose for treatment of periodontitis?

The Survivin Interactome in Health and Disease

We have 30 inhibitor PhD Projects, Programmes & Scholarships

inhibitor PhD Projects, Programmes & Scholarships

We have 30 inhibitor PhD Projects, Programmes & Scholarships

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