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innate PhD Projects, Programs & Scholarships

We have 89 innate PhD Projects, Programs & Scholarships

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  EASTBIO Sex dimorphisms in innate immunity, inflammatory pathology, and ageing
  Research Group: Institute of Immunology & Infection Research
  Dr J Regan, Dr S Jenkins
Application Deadline: 5 January 2020

Funding Type

PhD Type

Ageing is the largest risk factor for the developed world’s biggest killers, and the impact of age-related disease is one of society’s foremost challenges.
  Sex dimorphisms in innate immunity, inflammatory pathology, and ageing
  Research Group: Institute of Immunology & Infection Research
  Dr J Regan, Dr S Jenkins
Application Deadline: 5 January 2020

Funding Type

PhD Type

Ageing is the largest risk factor for the developed world’s biggest killers, and the impact of age-related disease is one of society’s foremost challenges.
  Nucleic Acid Sensing During Virus Infection – Innate Immunity
  Dr J Rehwinkel
Application Deadline: 10 January 2020

Funding Type

PhD Type

Virus infection is a constant threat to the cells of all living organisms. To counter this threat, cellular receptors detect virus presence and activate potent antiviral immune responses.
  Nucleic Acid Sensing During Virus Infection – Innate Immunity
  Dr J Rehwinkel
Application Deadline: 10 January 2020

Funding Type

PhD Type

Virus infection is a constant threat to the cells of all living organisms. To counter this threat, cellular receptors detect virus presence and activate potent antiviral immune responses.
  Virus pathogenesis: interplay between the unfolded protein response and innate immunity.
  Dr S-W Chan, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

The unfolded protein response (UPR) is a cellular homeostatic response in restoring endoplasmic reticulum balance upon stress conditions e.g.
  MRC DiMeN Doctoral Training Partnership: How does the human innate immune system kill the Streptococcus pneumoniae bacterium during infection?
  Dr A Fenton, Dr L Prince
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. The bacterium Streptococcus pneumoniae is a highly successful human pathogen and a leading cause of pneumonia, a disease responsible for millions of deaths every year.
  MRC DiMeN Doctoral Training Partnership: How does the human innate immune system kill the Streptococcus pneumoniae bacterium during infection?
  Dr A Fenton, Dr L Prince
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. The bacterium Streptococcus pneumoniae is a highly successful human pathogen and a leading cause of pneumonia, a disease responsible for millions of deaths every year.
  The contribution of human mast cells to innate functional memory in anti-bacterial responses
  Prof S Bulfone-Paus, Dr J Cavet
Applications accepted all year round

Funding Type

PhD Type

In the recent years, it has become evident that after infection or vaccination innate immune cells have the capacity to adapt and modify the nature of their activities following a single immunostimulatory challenge and display a long-term functional memory.
  PhD student position (f/m/d) in a research project analyzing the "Communication between neutrophilic granulocytes and other cells of the innate and adaptive immune system"
  Dr L Erpenbeck
Application Deadline: 31 December 2019

Funding Type

PhD Type

The Clinic for Dermatology, Venerology and Allergology offers as soon as possible a PhD student position (f/m/d) in a research project analyzing the "Communication between neutrophilic granulocytes and other cells of the innate and adaptive immune system" limited for 3 years, 19,25 h/week (50%).
  Ph.D. Fellowship in Intestinal Innate Immunity and Host Defense Peptides
  Dr E Cobo
Applications accepted all year round

Funding Type

PhD Type

RESEARCH. One Ph.D. position is available immediately at the University of Calgary, Canada to study gut innate immunity contributed by host defense peptides and immunoregulation in the epithelial and leukocyte cross-talking in response to microbial pathogens.
  Vitamin D and immunometabolism
  Prof M Hewison, Dr S Dimeloe
Applications accepted all year round

Funding Type

PhD Type

Vitamin D has potent anti-inflammatory and antibacterial immune effects.
  Regulation of innate immune response by enhancer elements and genetic variants within them
  Research Group: Functional Gene Control
  Dr M Spivakov
Application Deadline: 1 December 2019

Funding Type

PhD Type

Non-coding DNA elements such as gene enhancers play key roles in gene regulation, particularly upon stimulus response and in development.
  Regulation of intestinal immune responses to commensal bacteria by innate lymphoid cells
  Dr M Hepworth, Prof K Else
Applications accepted all year round

Funding Type

PhD Type

Commensal bacteria present in the gastrointestinal tract provide beneficial roles for the host, such as supporting nutrient metabolism.
  Inhibition of innate immunity by vaccinia virus: a discovery tool for host restriction factors
  Prof G L Smith
Application Deadline: 1 January 2020

Funding Type

PhD Type

The interaction between viruses and their host reveals a fascinating conflict between host defense and virus evasion. The project concerns vaccinia virus (VACV), the live vaccine used to eradicate smallpox, and how it shuts down host innate defenses.
  EASTBIO Understanding the rules of mitochondrial nucleic acid escape in innate immune activation
  Dr A Dhir, Dr S Tait
Application Deadline: 5 January 2020

Funding Type

PhD Type

Mitochondria are the ‘power-stations’ of our cell, providing energy for cellular function. Mitochondria have evolved from ancient bacteria that invaded our cells a billion of years ago and have ‘integrated’ into our biological system in an endosymbiotic relationship.
  Proteolytic network regulating the human innate immune response
  Dr D Boucher, Prof I Hitchcock
Application Deadline: 30 June 2020

Funding Type

PhD Type

The innate immune system is our first line of defence against a wide range of bacteria and viruses. Upon infection, immune cells, such as macrophages and neutrophils, will assemble signalling platforms termed inflammasome, to restrict and clear the insult.
  Modulation of platelet-mediated innate immune responses in chronic lymphocytic leukaemia
  Dr M Arman
Application Deadline: 31 March 2020

Funding Type

PhD Type

Chronic lymphocytic leukaemia (CLL) is the most common form of leukaemia in the Western World. B-cell receptor-induced intracellular signals are critical for the survival of leukaemia cells and disruption of this pathway by the Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib is a highly effective CLL therapy.
  Trained innate immunity in atherosclerosis
  Prof R Choudhury
Application Deadline: 10 January 2020

Funding Type

PhD Type

This laboratory studies the role of the innate immune system (monocytes / macrophages) on the progression and regression of atherosclerosis.
  Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam
  Dr M Soller
Applications accepted all year round

Funding Type

PhD Type

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response.
  Precision Medicine DTP – Investigating disease causing mutations in PNPase- an approach to understand mitochondrial nucleic acid driven auto-inflammation
  Research Group: Centre of Genomic and Experimental Medicine
  Dr A Dhir, Dr S Tait, Dr T Chandra
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Mitochondrial diseases are a heterogeneous class of disorders often characterized by failure of mitochondrial function and loss of energy associated with respiratory chain complex deficiency.
  Molecular mechanism of innate immunity mediated by the Toll/IL1 receptor signalling pathways.
  Prof N J Gay
Applications accepted all year round

Funding Type

PhD Type

This group participates in the Wellcome Trust 4 year PhD programme in Developmental biology., MRC and BBSRC Doctoral Training Programmes.
  Crosstalk between the circadian clock and innate immune system in plants
  Research Group: Institute of Molecular Plant Sciences
  Dr G van Ooijen, Dr S Spoel
Application Deadline: 5 January 2020

Funding Type

PhD Type

Involvement of the circadian clock in many aspects of human health is well recognised, but circadian input in plant immunity is not as well understood.
  EASTBIO Crosstalk between the circadian clock and innate immune system in plants
  Research Group: Institute of Molecular Plant Sciences
  Dr G van Ooijen, Dr S Spoel
Application Deadline: 5 January 2020

Funding Type

PhD Type

Involvement of the circadian clock in many aspects of human health is well recognised, but circadian input in plant immunity is not as well understood.
  Neural circuit basis of sexually dimorphic and learned behaviours in Drosophila
  Dr G Jefferis
Application Deadline: 3 December 2019

Funding Type

PhD Type

We study how sensory information is transformed into behaviour in the fly brain. We mostly use the olfactory system, because olfaction is a relatively shallow sense.
  (MCRC Non-Clinical) Manipulating the Tumour Microenvironment to Optimise TIL therapy
  Prof R Edmondson, Dr A Armstrong, Prof T Hussell, Prof F Thistlethwaite
Application Deadline: 1 December 2019

Funding Type

PhD Type

Adoptive T cell therapy is a novel and exciting form of immunotherapy. Key to ensuring it achieves its full clinical potential is to determine ways to optimise its efficacy.
  EASTBIO The Role of Autophagy in Inflamm-aging
  Dr M Gray, Dr G Cowan
Application Deadline: 5 January 2020

Funding Type

PhD Type

Aging is the greatest risk factor for the majority of chronic diseases, including muscle wasting, autoimmunity, Alzheimer’s and cardiovascular disease (CVD).
  Precision Medicine DTP – Investigating the metabolic alterations that initiate pre-neoplastic development in zebrafish and in humans
  Research Group: Centre for Inflammation Research
  Dr Y Feng, Dr K Burgess, Dr R Burchmore, Dr G Ho
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. “Warburg metabolism” is characterised by an increased uptake of glucose and its conversion to lactate by glycolysis under normoxia.
  Modelling of Oral Neutrophil Epithelial interactions
  Dr E Hagi-Pavli
Applications accepted all year round

Funding Type

PhD Type

Background and Clinical Significance. Neutrophils are an important and vital cellular component of the innate immune system providing rapid protection against microbial invasion.
  Characterizing the immunogenic properties of bacterial extracellular vesicles (EVs) of the Cystic Fibrosis airway
  Dr J Coppinger
Application Deadline: 2 December 2019

Funding Type

PhD Type

Recurrent Pseudomonas (P) aeruginosa infection is common in chronic pulmonary diseases including cystic fibrosis (CF), chronic obstructive lung disease (COPD) and a leading cause of hospital acquired pneumonia.
  (BBSRC DTP) Electron Paramagnetic Resonance Pulsed Dipolar Spectroscopy for Structural Biology
  Dr A Bowen, Dr S Hay, Dr M Shanmugam
Application Deadline: 31 January 2020

Funding Type

PhD Type

Electron Paramagnetic Resonance is a rapidly expanding suit of techniques used for the study of complex (bio)molecules that possess spin-active moieties with unaired electrons.
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