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We have 23 leukaemia PhD Projects, Programmes & Scholarships

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leukaemia PhD Projects, Programmes & Scholarships

We have 23 leukaemia PhD Projects, Programmes & Scholarships

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Defining the molecular mechanisms of leukaemia chemotherapies

The University of Manchester Faculty of Biology, Medicine and Health
Chemotherapies are usually the backbone of cancer treatment for either curative or palliative patient care. Multiple therapies can be used for the same disease, with the choice of drug dependent on parameters such as the patient’s age and fitness. Read more
 Supervisors: Dr JK Knight, Dr K Batta, Dr D Wiseman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Sensitizing AML cells to RAR and VDR ligands (vitamin A and D derivatives) to prevent leukaemia relapse

Medical University of Vienna Institute for Pathophysiologie and Allergy
The doctoral candidate (DC) will perform basic research on leukaemia cell biology in vitro and in vivo at the Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel. Read more
 Supervisor: Dr MD Danilenko
 29 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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The role of NFIA fusion genes in erythroid leukaemia

Cardiff University Cardiff School of Medicine
It is clear that the process of haematopoietic (blood) development is ultimately coordinated by transcription factors, a view supported by the prevalence of transcription factor abnormalities found in leukaemia. Read more
 Supervisor: Prof A Tonks
 3 May 2024  PhD Research Project  Funded PhD Project (European/UK Students Only)
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The BCAT1 CXXC Motif and Oncogenesis in Acute Myeloid Leukaemia

University of Worcester Research School
The BCAT1 gene is implicated in the pathogenesis of many cancer types, including acute myeloid leukaemia (AML)1–4. Recently, our group identified a novel antioxidant role for BCAT1 in AML cells5. Read more
 Supervisor: Dr S Coles
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the metabolic link between leukaemia and heart failure (RUSHWORTHS_U24BIGC)

University of East Anglia Norwich Medical School
Primary supervisor - Dr Stuart Rushworth. Secondary supervisor - Dr James Smith. Rushworth Lab. This 4-year PhD project funded by the Big C cancer charity represents an exciting opportunity to develop and conduct research at the forefront of cancer research. Read more
 Supervisor: Dr S Rushworth
 7 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Role of BTG1 and BTG2 in acute lymphocytic leukaemia and diffuse large B-cell lymphoma

University of Nottingham School of Pharmacy
Acute lymphocytic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) is often associated with small deletions of or point mutations in the highly related BTG1 or BTG2 genes. Read more
 Supervisor: Dr G S Winkler
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisor: Dr P Laslo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Linking phenotype to genotype in paediatric Acute Myeloid Leukaemia with GATA2 mutations

University of Birmingham Institute of Cancer and Genomic Sciences
The appointee will be PhD students in the area of paediatric oncology and be registered on the ‘The Azaylia Childhood Cancer PhD Programme’. Read more
 Supervisor: Dr R Monteiro
 13 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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REGULATION OF BCR SIGNALLING BY DNA DAMAGE RESPONSE AND P53 PROTEIN

Masaryk University Faculty of Medicine
Doctoral study program. Molecular Medicine. Research area. Cancer biology. Consultant. Marek Mraz, MD, Ph.D. We are looking for a motivated PhD student that would like to work on the following project funded by the ERC (European Research Council) Starting grant. Read more
 Supervisor: Dr MB Boudny
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Importance of RARγ for malignant potential of AML blasts

Medical University of Vienna Institute for Pathophysiologie and Allergy
The Doctoral Candidate (DC) will determine the roles of retinoic acid receptors (RAR) α and γ in the development of acute myeloid leukaemia (AML). Read more
 Supervisor: Prof E Marcinkowska
 29 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Genomic actions of RAR and VDR ligands

Medical University of Vienna Institute for Pathophysiologie and Allergy
The Doctoral Candidate (DC) will determine whether the combination of RARγ antagonist and VDR agonist is suitable as a differentiation therapy against acute myeloid leukaemia (AML). Read more
 Supervisor: Prof E Marcinkowska
 29 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Studying protein homeostasis in healthy and malignant stem cells

University of York York Biomedical Research Institute
This PhD will focus on studying the protein biology of healthy and malignant stem cells of the blood system. Read more
 Supervisors: Dr W Grey, Prof D G Kent
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Molecular Glues as Novel Tools for Tackling Big Challenges in Human Health

University of Leicester Department of Chemistry
Background. The need for new medicines is greater than ever because of an ageing population and the complex clinical challenges brought about by drug resistance and/or side effects. Read more
 Supervisors: Dr RD Doveston, Prof S Macip
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

University of Leeds Faculty of Biological Sciences
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more
 Supervisor: Dr J Boyes
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Developing virtual reality for paediatric neurorehabilitation

University of Sheffield Department of Computer Science
Brain and spinal cord tumours are the second most common types of cancer in children and young people (CYP) after leukaemia, accounting for approximately 1 out of every 4 childhood cancers. Read more
 Supervisor: Dr S C Maddock
 22 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia

University of Liverpool Institute of Systems, Molecular and Integrative Biology
This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more
 Supervisors: Dr M Papamichos Chronakis, Prof D MacEwan, Dr A Kanhere
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Creation of cell lines modelling complex karyotype in B cell lymphomas using CRISPR/Cas9

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Chronic lymphocytic leukaemia (CLL) and diffuse large B cell lymphoma (DLBCL) make up more than half of all the newly diagnosed cases of non-Hodgkin’s lymphoma (NHL), the 6th most common cancer in the UK. Read more
 Supervisors: Dr J Slupsky, Dr N Kalakonda, Dr M Glenn
 1 May 2024  PhD Research Project  Self-Funded PhD Students Only
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Analysing the role of statins in cardiovascular protection

University of Liverpool Department of Pharmacology and Therapeutics
Drug-induced cardiovascular toxicity is a major problem affecting a number of cancer chemotherapy drugs (Cross et al., 2015). Read more
 Supervisors: Dr M Cross, Dr B Wilm, Dr AM Mondru
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: m6A modification of segmentation clock mRNAs and its role in somitogenesis

University of Dundee School of Life Sciences
During early embryogenesis, segments (somites) are formed during a process called somitogenesis. These somites will go on to form the bones and muscles of the skeleton. Read more
 Supervisors: Prof J K Dale, Dr P Murray
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Analysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity

University of Liverpool Department of Pharmacology and Therapeutics
Liver sinusoidal endothelial cells (LSECs) comprise approximately 50% of the non-parenchymal hepatic cells. They play a vital role in hepatic microcirculation and provide a physiological barrier to the movement of xenobiotics from the bloodstream to hepatic tissue. Read more
 Supervisors: Dr M Cross, Prof C Goldring
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Improvements of asparaginase-based treatment for Childhood ALL

Cardiff University Cardiff School of Biosciences
Project Description. Most popular current treatments for childhood acute lymphoblastic leukaemia (ALL) in clinic are based on asparaginase (Raja et al 2012). Read more
 Supervisors: Dr O V Gerasimenko, Dr J Gerasimenko
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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ROLE OF FOXO1 TRANSCRIPTION FACTOR IN B-CELL MALIGNANCIES

Masaryk University Faculty of Medicine
The project is focused on FoxO1 transcription factor and its role in the pathophysiology of chronic lymphocytic leukemia (CLL). Although the therapy of CLL has made several remarkable improvements, the disease still remains incurable. Read more
 Supervisor: Assoc Prof Marek Mraz
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Haematology: Oncogenic reprogramming of immune cells

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisors: Dr F Errington-Mais, Dr P Laslo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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