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FindA University Ltd Featured PhD Programmes
FindA University Ltd Featured PhD Programmes

metabolism PhD Projects, Programs & Scholarships

We have 86 metabolism PhD Projects, Programs & Scholarships

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  Bioengineering of bacterial CO2-concentrating system for improved photosynthesis
  Prof LN Liu, Dr D Canniffe
Applications accepted all year round

Funding Type

PhD Type

The single-cell photosynthetic bacteria, cyanobacteria, account for over 25% of global carbon fixation, thanks for their powerful CO2-concentrating machinery.
  Characterising and repurposing cyanobacterial CO2-fixing organelles for metabolic engineering
  Prof LN Liu, Dr J Hartwell
Applications accepted all year round

Funding Type

PhD Type

Compartmentalisation represents an effective strategy used by cells to enhance their activities. By creating physical barriers and compartments, cells sequester the metabolic pathways from the cellular milieu to allow controls of metabolic flux and toxic diffusion.
  Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials
  Dr V Liu, Dr L Swanton
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function.
  Defining the microbiome environment in patients with biliary tract cancer and its implications for therapy
  Prof J W Valle, Dr M McNamara
Applications accepted all year round

Funding Type

PhD Type

Biliary tract cancers (BTCs) encompass cancers of the extrahepatic/intrahepatic bile ducts, gallbladder and ampullary carcinoma. The only potentially curative option is surgical resection; median overall survival (OS) in the advanced setting.
  Maternal anti-hypertensive medicines & placental vascular function
  Dr P Brownbill, Dr J Myers, Dr E Johnstone
Applications accepted all year round

Funding Type

PhD Type

A range of anti-hypertensive medicines are prescribed to women with chronic hypertension in pregnancy, that enter the fetal circulation.
  The mechanism of regulation of protein synthesis via eIF2 molecular complexes
  Dr A Roseman, Prof G D Pavitt
Applications accepted all year round

Funding Type

PhD Type

Control of protein synthesis is critical for normal metabolism, development and responses to stress. One major pathway is called the integrated stress response (ISR) and centres on translational control of the general protein synthesis factor eIF2B via the phosphorylation of eIF2 [1,2].
  Towards artificial signal transduction in living cells
  Dr S Webb
Applications accepted all year round

Funding Type

PhD Type

The development of synthetic molecules able to transmit biochemical information across phospholipid bilayers could lead to a new type of synthetic biology, where the introduction of orthogonal signalling pathways leads to ‘short-circuiting’ of natural signalling networks in cells.
  Enzymes of endocannabinoid turnover in inflammatory responses
  Dr SPH Alexander
Applications accepted all year round

Funding Type

PhD Type

Over recent years, we have generated, developed and established a wide range of assays for different enzyme activities.
  Regulation of clostridial solvent production by quorum sensing
  Dr K Winzer, Dr Y Zhang
Applications accepted all year round

Funding Type

PhD Type

Background. The genus Clostridium comprises a large group of strictly anaerobic and metabolically diverse spore-forming bacteria.
  Sex hormone actions in frailty and health during ageing
  Dr M Garratt
Applications accepted all year round

Funding Type

PhD Type

It is well established that testosterone and estrogens can influence ageing, with hormone administration improving physical function, muscle and bone strength in some cohorts of the elderly.
  Impact of maternal obesity on offspring adipogenesis
  Dr D Sellayah
Applications accepted all year round

Funding Type

PhD Type

Obesity is the major health crisis of this generation. Thus, research into the mechanistic basis behind obesity is of paramount importance.
  The impact of protein ubiquitination on ageing and ageing-associated diseases
  Dr E Kevei
Applications accepted all year round

Funding Type

PhD Type

"Ageing is characterized by a general functional decline of cells, tissues and organs with increased risk of disease, such as neurodegenerative disorders.
  The relationship between dietary iron and zinc, and the gut microbiota: Can dietary iron and zinc regime be exploited to improve health?
  Prof S C Andrews
Applications accepted all year round

Funding Type

PhD Type

"The gut microbiota (100 trillion cells) outnumber human cells by 10 to 1. Its composition of around 500 to 1000 species is specific for each individual and is dynamic, changing with age, health and diet.
  Transdermal and Topical Drug Delivery: developing novel formulations to increase drug delivery into and through skin
  Prof A Williams
Applications accepted all year round

Funding Type

PhD Type

Human skin is a remarkable self-repairing barrier that controls the ingress of environmental contaminants and regulates water loss from the body.
  PhD in the Biosynthesis and Enzymology of Fluorine Containing Metabolites in Streptomyces Bacteria
  Prof D O'Hagan
Applications accepted all year round

Funding Type

PhD Type

Research in the O’Hagan group has had a focus on the biosynthesis of fluorine containing natural products and the identification of a fluorination enzyme, ‘the fluorinase’, from Streptomyces cattleya.[1] Fluorine is very rare in nature, and in those rare cases where an organism can form a C-F bond from fluoride ion, then the enzymology is unique and interesting.
  An investigation into Soft Tissue Biomechanics Using Computational Fluid Dynamics
  Dr M Lappa
Applications accepted all year round

Funding Type

PhD Type

Aim of the present project is the modelling and numerical simulation of soft-tissue growth in rotating bioreactors and related morphological evolution.
  Actin regulation of nuclear mechanics during DNA repair
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

In eukaryotic cells, the nucleus houses the genomic material and transcription machinery that allows the cell to develop and perform its role.
  HDAC inhibitors: a potential therapy for breast cancer?
  Dr C Staton, Dr B Corfe
Applications accepted all year round

Funding Type

PhD Type

Radiation resistance, due to hypoxia, remains a major cause of mortality in the treatment of breast cancer.
  High-throughput mechanobiology
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

Cancer research has traditionally focused upon extra- or intra-cellular biochemical signals, and their relation to cancer development and metastasis.
  Proteomic Markers of Chronic Renal Scarring
  Dr P Watson
Applications accepted all year round

Funding Type

PhD Type

All types of chronic kidney disease (CKD) progress to end stage renal failure through a common pathway of fibrosis and scarring. Subsequently 2 million patients worldwide require renal replacement therapy (RRT).
  Treating cancer by targeting the mechanical properties of cells
  Dr A Gad
Applications accepted all year round

Funding Type

PhD Type

Cancer development is marked by massive increase of matrix fibres around tumor cells, which changes the mechanical properties of the tissue and is used to diagnose tumours by manual palpation.
  Determining the translational potential of the highly phosphorylated proto-oncogene PBF
  Dr V Smith
Applications accepted all year round

Funding Type

PhD Type

In order to translate the many molecular alterations now detectable in human tumours into effective clinical management we need to fully understand their impact on tumour biology.
  Polo-like kinase inhibitors for targeted therapy in adrenocortical carcinoma
  Dr C L Ronchi, Dr P Foster
Applications accepted all year round

Funding Type

PhD Type

Adrenocortical carcinoma (ACC) is a rare cancer with a generally poor prognosis and partially unknown pathogenesis.
  Repairing DNA Damage in Response to BRAF Mutation
  Dr C McCabe, Prof G Stewart
Applications accepted all year round

Funding Type

PhD Type

We are the leading thyroid cancer research group in the UK; we work on other neoplasias as well, including breast and head and neck etc.
  Novel bone-targeted therapy for treatment against dormant myeloma cells
  Dr M Lawson, Dr A Chantry
Application Deadline: 1 September 2019

Funding Type

PhD Type

Multiple myeloma is a cancer of differentiated B-lymphocytes (plasma cells) that grow in the bone marrow. Despite the development and use of more effective drugs in the treatment of myeloma it remains an incurable disease, given that current treatment regimens are not able to eradicate all tumour cells.
  Novel niclosamide-bisphosphonate vectors as bone-targeted therapy for multiple myeloma
  Dr M Lawson, Dr A Chantry
Application Deadline: 1 September 2019

Funding Type

PhD Type

Myeloma remains an incurable cancer despite improvements in survival outcomes over the last few years, due to the development of better therapies.
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