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mitochondria PhD Projects, Programs & Scholarships

We have 34 mitochondria PhD Projects, Programs & Scholarships

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  Elucidating the interplay between mitochondrial dynamics, organelle contact sites and metabolic (re)programming (On the University’s application portal, please select "PhD in Medical Science at the MRC Mitochondrial Biology Unit").
  Dr J Prudent
Application Deadline: 30 June 2020

Funding Type

PhD Type

Mitochondria house hundreds of biochemical reactions involved in processes critical for the survival and homeostatic adaptation of the cell.
  MRC DiMeN Doctoral Training Partnership: How does mitochondrial morphology change in neurons with age and disease?
  Dr A Reeve, Dr C Racca, Dr A Vincent
Application Deadline: 6 January 2020

Funding Type

PhD Type

Mitochondria are fundamental to the function of our neurons, and defects in the function of this important organelle are found in several neurodegenerative disorders, as well as in normal ageing.
  (BBSRC DTP) Understanding mitochondrial protein quality control under normal and stress conditions
  Dr H Lu, Prof C M Grant, Prof S Hubbard
Application Deadline: 31 January 2020

Funding Type

PhD Type

Mitochondria are vitally important organelles within living cells and are often described as their powerhouses, as the primary energy source for all biological activities.
  EASTBIO Understanding the rules of mitochondrial nucleic acid escape in innate immune activation
  Dr A Dhir, Dr S Tait
Application Deadline: 5 January 2020

Funding Type

PhD Type

Mitochondria are the ‘power-stations’ of our cell, providing energy for cellular function. Mitochondria have evolved from ancient bacteria that invaded our cells a billion of years ago and have ‘integrated’ into our biological system in an endosymbiotic relationship.
  Targeting molecules to mitochondria, mitochondrial radical production, thiol redox state and redox signalling (On the University’s application portal, please select "PhD in Medical Science at the MRC Mitochondrial Biology Unit").
  Prof M Murphy
Application Deadline: 30 June 2020

Funding Type

PhD Type

Targeting molecules to mitochondria. Bioactive molecules can be targeted to mitochondria within cells by linking them to lipophilic cations.
  MRC DiMeN Doctoral Training Partnership: Elucidating Disease Mechanisms using New Approaches to Capture Transient Protein Complexes in the Mitochondria
  Prof L-Y Lian, Prof A J Wilson
Application Deadline: 6 January 2020

Funding Type

PhD Type

The mitochondria is the powerhouse of the cell. Its malfunction is the cause of many diseases, ranging from cancer to heart and neurological diseases, which become more prevalent with age.
  Proteomic approach to understand mitochondrial quality control under normal and stress conditions
  Dr H Lu, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Defects in protein quality control lead to the accumulation of misfolded and damaged proteins, which play an important role in many diseases (e.g.
  Finding the eat-me signals
  Dr I Ganley
Application Deadline: 1 December 2019

Funding Type

PhD Type

The Ganley lab is interested in unravelling the molecular mechanism of autophagy (which literally translates from the Greek meaning to eat oneself).
  China Scholarship Council - Finding the eat-me signals
  Dr I Ganley
Application Deadline: 15 January 2020

Funding Type

PhD Type

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students.
  An exploration of the links between mitochondrial function and splicing regulation. PhD in Medical Studies (SWBio DTP)
  Dr L Harries
Application Deadline: 2 December 2019

Funding Type

PhD Type

Lead Supervisor. Professor Lorna Harries, College of Medicine and Health, University of Exeter. Additional Supervisors. - Professor Mark Lindsay, Department of Pharmacy and Pharmacology, University of Bath.
  Hydrogen sulphide as a treatment for respiratory disease.
  Dr R Roberts, Dr SPH Alexander
Applications accepted all year round

Funding Type

PhD Type

We have demonstrated that hydrogen sulphide (H2S) is synthesised within the airways in the lungs. H2S synthesis in the airways occurs through activation of the enzymes cystathionine  lyase, cystathionine β synthase, and mercaptopyruvate sulphurtransferase (MPST).
  Elucidating the role of the Omp85/BamA-related protein OEP80 in chloroplast β-barrel biogenesis
  Prof P Jarvis
Application Deadline: 24 January 2020

Funding Type

PhD Type

Link to group webpage. http://users.ox.ac.uk/~dops0547/. Chloroplasts belong to a diverse family of plant organelles termed plastids [1].
  Role and mechanism of mitochondrial transport proteins (On the University’s application portal, please select "PhD in Medical Science at the MRC Mitochondrial Biology Unit").
  Prof E Kunji
Application Deadline: 30 June 2020

Funding Type

PhD Type

Mitochondria are central to the utilization of sugars and fat by the eukaryotic cell in order to synthesise ATP via oxidative phosphorylation.
  MRC DiMeN Doctoral Training Partnership: Mitochondrial DNA mutations in blood: Why do they decline?
  Dr S Pickett, Prof M Collins, Dr O Russell
Application Deadline: 6 January 2020

Funding Type

PhD Type

Mitochondrial diseases are caused by mutations in nuclear and mitochondrial (mt) genomes and there is currently no cure for these debilitating disorders.
  Precision Medicine DTP – Investigating disease causing mutations in PNPase- an approach to understand mitochondrial nucleic acid driven auto-inflammation
  Research Group: Centre of Genomic and Experimental Medicine
  Dr A Dhir, Dr S Tait, Dr T Chandra
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Mitochondrial diseases are a heterogeneous class of disorders often characterized by failure of mitochondrial function and loss of energy associated with respiratory chain complex deficiency.
  Regulation of membrane contact sites in mammalian cells. PhD in Biosciences (SWBio DTP)
  Dr J Costello
Application Deadline: 2 December 2019

Funding Type

PhD Type

Lead Supervisor. Dr Joseph Costello, Department of Biosciences, College of Life and Environmental Sciences, University of Exeter.
  Investigating Noise in Ageing Cellular Power Stations
  Prof N Jones
Applications accepted all year round

Funding Type

PhD Type

PhD Project. Imperial College Mathematics. Student Background. Theoretical Physics, Mathematics/Statistics, Electrical Engineering (Biological knowledge not required).
  Carbon nanotubes in the boron neutron capture therapy of cancer
  Dr G Calabrese
Applications accepted all year round

Funding Type

PhD Type

The early promise of boron neutron capture therapy as a method for the treatment of brain cancer has been mainly inhibited by the inherent toxicity associated with 10B-containing pharmacophores and the need for the ability to cross biological membranes.
  Using a novel 3D co-culture model to define metabolic flux maps of different cancer cell types in response to physical activity
  Dr M Morris, Dr A Islam, Prof M.P. Lewis
Applications accepted all year round

Funding Type

PhD Type

During exercise, and in the presence of sufficient oxygen, glucose is metabolised by muscle cells to produce pyruvate, a metabolic intermediate which is fed into the Kreb’s cycle in the mitochondria to produce large amounts of energy.
  Mitochondrial calcium in neurodegeneration (PhD in Biological Science at the MRC Mitochondrial Biology Unit)
  Dr A J Whitworth
Application Deadline: 30 June 2020

Funding Type

PhD Type

Mitochondrial calcium plays a key role in a wide array of cellular homeostatic processes as diverse as bioenergetics and cell death, and has been linked to disease conditions as varied as cancer, ischemia-reperfusion injury and neurodegeneration (1-3).
  Regulation of mitochondrial gene expression (On the University’s application portal, please select "PhD in Medical Science at the MRC Mitochondrial Biology Unit").
  Dr M Minczuk
Application Deadline: 30 June 2020

Funding Type

PhD Type

MRC Mitochondrial Biology Unit. The key objective of this PhD project is to study nuclear-encoded proteins involved in mitochondrial (mt-) RNA metabolism, in order to understand how their dysfunction is linked to human mitochondrial pathologies.
  The mechanism, function, and medically-relevant dysfunction of mitochondrial complex I (NADH:ubiquinone oxidoreductase) (On the University’s application portal, please select "PhD in Medical Science at the MRC Mitochondrial Biology Unit").
  Prof J Hirst
Application Deadline: 30 June 2020

Funding Type

PhD Type

Complex I (NADH:ubiquinone oxidoreductase) catalyses the first step in the respiratory chain and oxidative phosphorylation. NADH oxidation and quinone reduction, coupled to proton translocation across the inner membrane.
  (BBSRC DTP) Cardiac Physiology in the World’s Oldest Vertebrate, The Greenland Shark
  Dr H Shiels, Dr G Galli
Application Deadline: 31 January 2020

Funding Type

PhD Type

The life span of the Greenland shark is at least 272 years and may be as long as 500 years making this animal the longest living vertebrate on the planet1.
  (BBSRC DTP) Kinesin light chains: why so many?
  Prof V Allan, Prof M Ashe, Dr G Poulin
Application Deadline: 31 January 2020

Funding Type

PhD Type

Kinesin-1 is a microtubule motor that moves many cargoes within cells, and this transport is crucial for life and health.
  (MCRC Non-Clinical) Defining the Bcl-2 family interactome to optimise breast cancer cell response to chemotherapy
  Dr A P Gilmore, Prof K R Brennan, Dr R Clarke, Dr S Howell
Application Deadline: 1 December 2019

Funding Type

PhD Type

Project summary. More than 80% of breast cancer (BC) patients can be treated with targeted drugs like tamoxifen or trastuzumab, which have significantly reduced mortality rates over the past 20 years.
  Metabolic control of T cell function
  Dr S Dimeloe
Applications accepted all year round

Funding Type

PhD Type

Current research interests in Sarah Dimeloe’s lab focus on the metabolism and interlinked immune function of T lymphocytes in health and disease.
  Studying the Molecular Mechanism of Mitochondrial Aminoacyl tRNA Synthetases in Neurons
  Dr R Horvath, Prof P Chinnery
Application Deadline: 3 December 2019

Funding Type

PhD Type

Aminoacyl-tRNA synthetases (ARSs) are essential and ubiquitous ‘house-keeping’ enzymes responsible for charging amino acids to their cognate tRNAs and provide the substrates for global protein synthesis in the cytosol and mitochondria.
  Precision Medicine DTP – Investigating the metabolic alterations that initiate pre-neoplastic development in zebrafish and in humans
  Research Group: Centre for Inflammation Research
  Dr Y Feng, Dr K Burgess, Dr R Burchmore, Dr G Ho
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. “Warburg metabolism” is characterised by an increased uptake of glucose and its conversion to lactate by glycolysis under normoxia.
  MRC Precision Medicine DTP: Target autophagy and aberrant mitochondrial folate metabolism in leukaemic stem cells
  Research Group: Institute of Cancer Sciences
  Dr V Helgason, Dr A Vazquez
Application Deadline: 8 January 2020

Funding Type

PhD Type

Supervisors. Dr Vignir Helgason. Dr Alexei Vazquez. Dr Zuzana Brabcova. Project summary. Chronic myeloid leukaemia (CML) develops following a specific mutation in a single blood stem cell.
  MRC DiMeN Doctoral Training Partnership: Relating skeletal muscle oxygenation dynamics to exercise intolerance mechanisms in heart failure: patient-specific interpretation of near infrared spectroscopy measurements
  Dr A.P. Benson, Dr C Ferguson, Prof S Egginton
Application Deadline: 6 January 2020

Funding Type

PhD Type

Heart failure is a complex clinical syndrome, the principal symptom of which is profound exercise intolerance (an inability to perform even day-to-day activities), the severity of which relates to disease severity.
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