mutagenesis PhD Projects, Programmes & Scholarships

We have 25 mutagenesis PhD Projects, Programmes & Scholarships

Understanding Spinal Cord Regeneration: The role of dynamic gene expression

The University of Manchester Faculty of Biology, Medicine and Health

Spinal cord injury(SCI) paralysis is a devastating disease that affects at least 2500 people per year in the UK. It carries substantial individual and societal costs with most SCI sufferers experiencing chronic pain. Read more

Supervisors: Dr X Soto Rodriguez, Dr K Dorey, Dr Cerys Manning

Year round applications PhD Research Project Self-Funded PhD Students Only

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Revealing Reactivity in Cancer-Associated Heme Proteins: Novel Time-Resolved Structural Approaches

University of Leicester Molecular and Cell Biology

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme involved in the degradation of tryptophan to kynurenine. Cancer cells upregulate IDO1 to escape normal immune responses and, in many cases, a high expression of IDO1 is connected to poor prognosis. Read more

Supervisors: Dr HK Kwon, Dr P A Ash

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

University of Leicester Department of Chemistry

Redox properties of metal-containing active sites are critically important to many biocatalytic processes. one third of all proteins contain a redox-active metal, and ca 22% of submissions to the Protein Data Bank contain a transition metal. Read more

Supervisors: Dr PA Ash, Dr H Kwon

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Younger, happier and more productive plants: using developmental genetics to improve herb yields and quality

University of Bristol School of Biological Sciences

If you’ve ever grown coriander at home you’ll have noticed that once the plant flowers it no longer produces the leaves used for seasoning. Read more

Supervisor: Dr J Fouracre

Year round applications PhD Research Project Self-Funded PhD Students Only

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Bringing Palladium Chemistry into the Biocatalytic Toolbox.

University of Edinburgh School of Chemistry

A PhD studentship is available in the group of Dr Amanda Jarvis, School of Chemistry, University of Edinburgh, (https://www.amandajarvis.co.uk/ ). Read more

Supervisor: Dr A Jarvis

Year round applications PhD Research Project Funded PhD Project (UK Students Only)

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Unravelling the role of genotoxic E. coli in colorectal cancer (SCHULLERS_U24BIGC)

University of East Anglia Norwich Medical School

Primary supervisor - Dr Stephanie Schüller. Secondary supervisor - Prof Nathalie Juge. Colorectal cancer (CRC) is the third most common and second most fatal cancer globally. Read more

Supervisor: Dr S Schüller

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Elucidation of a new pathological mechanism for brittle bone disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

The incidence of the brittle bone disease osteogenesis imperfecta (OI) is estimated to be around 1 in 10,000 individuals. The phenotypic spectrum of OI ranges from mild to perinatal lethal and includes extra-skeletal connective tissue manifestations. Read more

Supervisor: Dr EG Laird

Year round applications PhD Research Project Self-Funded PhD Students Only

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Targeting Ras palmitoylation for the treatment of cancer

University of Dundee School of Medicine

Lay summary. Proteins can be thought of as molecular machines that carry out work within cells. Protein activity can be regulated through the reversible attachment of certain chemical groups to specific amino acids within proteins. Read more

Supervisor: Dr N Fraser

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Structural and functional characterisation of MALT1 ubiquitination to aid in the development of novel anti-cancer therapies

University of Leicester Molecular and Cell Biology

Nuclear factor-kappa B (NF-kB) is a family of transcription factors that play a crucial role in regulating various cellular processes; primarily related to immune responses, inflammation, and cell survival. Read more

Supervisor: Dr G Hall

Year round applications PhD Research Project Self-Funded PhD Students Only

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Synthetic and Mechanistic Studies into Enzymatic Degradation of Waste Plastics

The University of Manchester Department of Chemistry

Plastics are a broad range of solid polymeric materials that have found widespread application globally. However, there has been a steady accumulation of discarded plastics and there is now growing awareness that they present a significant hazard to the natural environment and human health. Read more

Supervisor: Dr L Wong

Year round applications PhD Research Project Self-Funded PhD Students Only

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MSc by Research: Molecular mechanisms underlying aphid effector virulence activity

University of Dundee School of Life Sciences

Pests and diseases are a major threat to food security with losses ranging between 20-40%. Aphids are one of the most devastating insect pests, globally. Read more

Supervisor: Dr J Bos

Year round applications PhD Research Project Self-Funded PhD Students Only

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Structural and functional analysis of the protein complexes which regulate cell fate decisions to identify novel cancer therapies

University of Leicester Molecular and Cell Biology

Whether a cell dies or not has profound consequences on health and disease. In healthy tissue, cells that acquire high levels of genetic damage are safely removed via a process of programmed cell death. Read more

Supervisor: Dr JF Fox

Year round applications PhD Research Project Self-Funded PhD Students Only

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4-year PhD Studentship: Combatting bacterial zoonoses through multi-disciplinary studies of virulence factors

University of Bristol Bristol Veterinary School

Vector-borne diseases, including bacterial zoonoses, pose a significant threat to human and animal health and to livestock industries, particularly in low and middle-income countries. Read more

Supervisor: Dr T Cogan

Year round applications PhD Research Project Self-Funded PhD Students Only

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Structure-based design of allosteric modulators for G protein-coupled receptors using molecular modelling and pharmacology experiments

Queen’s University Belfast School of Pharmacy

Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more

Supervisors: Dr I Tikhonova, Dr B Plouffe

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the mechanisms of antibacterial action of silver and copper ions and nanoparticles, and the emerging threat of metal-ion resistance

University of Reading Department of Biomedical Sciences

Project Overview. The emergence of bacterial strains with resistance to multiple classes of antibiotics has led to renewed interest in the antimicrobial properties of metals including silver. Read more

Supervisor: Dr G Mulley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the role of P2X7 receptor intracellular domains in cell signalling

Cardiff University Cardiff School of Biosciences

Project description. P2X7 receptors are ion channels that are found on the surface of immune cells, where they respond to the binding of extracellular ATP, a damage signal released by dying cells in infection and injury. Read more

Supervisors: Dr M Young, Dr J Parker

Year round applications PhD Research Project Self-Funded PhD Students Only

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Building new nano-biosensors for healthcare: Linking biology to the world of carbon nanotechnology through synthetic biology

Cardiff University Cardiff School of Biosciences

Project Descriptions. Proteins are nature’s very own molecular machines carrying out functions ranging from catalysis to molecular recognition to energy conversion. Read more

Supervisors: Prof D Jones, Dr M Palma, Dr WK Kelton

Year round applications PhD Research Project Self-Funded PhD Students Only

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Unlocking immune cells with tick-borne pathogens

University of Bristol Faculty of Health Sciences

In this project we will use tick-borne pathogenic bacteria as a molecular tool-kit for unlocking immune cells. These discoveries will help us combat tick-borne disease and provide a basis for manipulating immune cells, impacting on a wide range of diseases. Read more

Supervisors: Dr I Cadby, Dr J Mann, Dr E Ballou

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Molecular mechanism of vimentin induced epithelial mesenchymal transition (EMT) and stemness in cancer cells

Queen Mary University of London Institute of Dentistry

Background. Most cancers are epithelial in origin and arise from a single progenitor cell, similar to an embryo, to become a clone of cells. Read more

Supervisors: Prof A Waseem, Dr H Tummala, Dr F Flores-Borja

Year round applications PhD Research Project Self-Funded PhD Students Only

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Possible role of mutant vimentin in cancer progression and metastasis

Queen Mary University of London Institute of Dentistry

Background. This project will investigate the role of the cytoskeletal protein vimentin in cancer progression and metastasis using cell and molecular biology approaches. Read more

Supervisors: Prof A Waseem, Dr F Flores-Borja, Dr H Tummala

Year round applications PhD Research Project Self-Funded PhD Students Only

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Taking Light Induced Electron Paramagnetic Resonance In Cell for Biological Structural Determination

The University of Manchester Department of Chemistry

Studying the structure of proteins and other biological systems is an important step in understanding their function. Most structural studies are conducted in environments that are far away from native conditions, such as those found inside a cell. Read more

Supervisors: Dr A Bowen, Dr J Rowbotham, Dr I Riddell, Dr D Heyes

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

University of Sheffield School of Biosciences

Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more

Supervisor: Dr C Guo

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding transcription factor complexes controlling endothelial cell quiescence and escape from quiescence

University of Nottingham Division of Cancer and Stem Cells

Endothelial cell proliferation and lymphatic cell proliferation is initiated during angiogenesis and lymphangiogenesis respectively and are both regulated by the VEGF signalling pathway. With some exceptions, endothelial and lymphatic cells in healthy individuals are quiescent and do not proliferate. Read more

Supervisors: Dr S Jayaraman , Prof K Gaston, Dr AB Benest

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding transcription factor complexes in endothelial quiescence

University of Nottingham Division of Cancer and Stem Cells

Endothelial cell proliferation and lymphatic cell proliferation known as angiogenesis and lymphangiogenesis respectively are both regulated by ligands in the VEGF signalling pathway. Read more

Supervisors: Dr S Jayaraman , Prof K Gaston, Dr AB Benest

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating bacteria-bacteriophage diversity to develop phage libraries for treatment of bacterial infections

University of Reading Department of Biomedical Sciences

Project Overview. The World Health Organisation (WHO) predicts antimicrobial resistant (AMR) infections will be the leading cause of death globally by 2050. Read more

Supervisor: Dr G Mulley

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 25 mutagenesis PhD Projects, Programmes & Scholarships

mutagenesis PhD Projects, Programmes & Scholarships

We have 25 mutagenesis PhD Projects, Programmes & Scholarships

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