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php PhD Projects, Programs & Scholarships

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  Precision Medicine DTP - Molecular dynamics of the response to breast cancer therapies
  Research Group: Edinburgh Cancer Research Centre
  Dr A Sims, Dr T Cannings
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Surgery is still the gold standard approach for treating cancer, most therapies are given after tumour excision, making it difficult to examine how cancer cells respond directly in patients.
  Precision Medicine DTP - Omics Prediction of Incident Disease
  Research Group: Centre of Genomic and Experimental Medicine
  Dr R Marioni, Dr C Hayward, Dr C Vallejos
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Disease prediction years prior to onset is a major goal for biomedical research. This may be possible through the development of cutting edge statistical and machine learning tools and their application to millions of biological data points from thousands of individuals.
  Precision Medicine DTP - Proteomic analysis of FAK function in human pancreatic cancer
  Research Group: Centre for Inflammation Research
  Dr A Serrels, Dr A Byron, Dr A von Kriegsheim
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. In the United Kingdom, the 5-year survival rate for patients with pancreatic ductal adenocarcinoma (PDAC) is just 3% (Cancer Research UK statistics), and as a result pancreatic cancer is the 4th most common cause of cancer death in the UK and US.
  Precision Medicine DTP - Stromal transcriptomic signatures in prostate cancer metastasis and hormone therapy resistance
  Research Group: MRC Centre for Reproductive Health
  Dr B Qian, Prof H Y Leung, Dr A Sims, Prof P Wiklund
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. A tremendous amount of cancer ‘-omics’ data have been generated with the intention to stratify patients for personalized diagnosis and treatment.
  Precision Medicine DTP - Synthetic chromosomes to understand genome instability
  Research Group: MRC Human Genetics Unit
  Prof N Gilbert, Prof A Marston
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Genomic instability in cancer has been known for many years; the advent of genomic analyses in the late 1990’s enabled these changes to be characterized in detail.
  Precision Medicine DTP - Taming the Hippo in mesothelioma through proteogenomics
  Research Group: Centre for Inflammation Research
  Dr C G Hansen, Prof J Lehtio
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Pleural Mesothelioma is an asbestos-related cancer, which originates in the pleural lining of the lung and is characterized by a diverse phenotype.
  Precision Medicine DTP - Understanding the neurobiological basis of co-morbid chronic pain and depression by integrating genomics, peripheral biomarkers and neuroimaging data
  Research Group: Centre for Clinical Brain Sciences
  Dr H Whalley, Prof M Fallon, Dr D Smith, Dr T-K Clarke
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Chronic pain is a major public health problem affecting one fifth of the general population(1). Major depressive disorder (MDD) is also a major health concern and is now the leading cause of disability worldwide(2).
  Precision Medicine DTP – Using Omics to Understand the Genes and Pathways Underlying Alcohol Use Disorder
  Research Group: Centre of Genomic and Experimental Medicine
  Dr K Evans, Dr T-K Clarke, Dr S Glerup
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Alcohol use disorder (AUD) is a chronic relapsing brain disease characterised by compulsive alcohol use, loss of control over alcohol intake, and a negative emotional state when not using alcohol.
  Precision Medicine DTP - 3D Modeling of Changes in Genome Architecture in Development and Disease
  Research Group: Institute of Cell Biology
  Prof E Schirmer, Dr D Marenduzzo
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Defects in spatial genome organisation have recently been linked to human disease and the National Institutes of Health, USA director speculated that most as yet unidentified disease alleles will occur in non-coding genome regions.
  Precision Medicine DTP – A novel data integration method for cellular social networks within self-organising multicellular systems
  Research Group: Institute of Stem Cell Research
  Dr G Blin, Dr L Schumacher, Dr A Tsanas
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. The quantification and interrogation of how the cells organise and interact with their environment is fundamental for advancing developmental biology, cancer research, pharmaceutics and medical diagnostics.
  Precision Medicine DTP - Accurate methods for rare variant calling in low-coverage cancer exome sequencing data
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr G Stracquadanio, Dr G Sanguinetti
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. High-throughput sequencing technologies enabled the characterization of the genomic landscape of many tumours (1,2).
  Precision Medicine DTP - Analysis of signaling pathways underlying development of human haematopoietic stem cells (HSCs)
  Prof A Medvinsky, Dr K Kaji, Dr A Ivens
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Haematopoietic stem cells (HSCs) are broadly used in the clinic to treat blood disorders, but there is a shortage of these cells to meet clinical demands.
  Precision Medicine DTP - Connecting Molecular Profiles to Phenotype: A Proteomic Resource for Assigning Cell Cycle and Senescent States
  Research Group: Institute of Cell Biology
  Dr T Ly, Dr A Lindqvist
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. A hallmark of cancer is aberrant cell cycle control leading to pathological cell proliferation. Cell cycle progression is controlled by key kinases, such as cyclin-dependent kinases (CDKs) and polo-like kinases (PLKs).
  Precision Medicine DTP - Defining and predicting the molecular basis for male infertility
  Research Group: Institute of Cell Biology
  Dr J Welburn, Dr J Marsh
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Male infertility is on the rise. While the genetics and molecular mechanisms underlying the phenomenon remain poorly understood, mutations in >75 human protein-coding genes have already been confidently linked to male infertility (Oud et al, 2019).
  Precision Medicine DTP - Dynamic changes that protect oocytes from chromosome mis-segregation
  Research Group: Institute of Cell Biology
  Prof H Ohkura, Dr T Ly, Dr A Kouznetsova
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Before fertilisation, oocytes arrest in metaphase in humans, as well as many other animal species including mouse and Drosophila.
  Precision Medicine DTP - Investigating the contribution of rare genetic variants to depression
  Research Group: Institute of Evolutionary Biology
  Dr S Knott, Dr P Navarro, Prof C Haley
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Genome-wide association studies (GWAS) are revealing the role of common genetic variants in the control of diseases and underlying traits.
  Precision Medicine DTP - The role of transcription factors and the signaling environment in commitment of cells into the germline
  Research Group: Institute of Stem Cell Research
  Prof I Chambers, Dr T Chandra
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. In mammals, specification of the germline occurs shortly after implantation. Understanding how germ cells become specified is important both to inform the treatment of human infertility, for example through in-vitro spermatogenesis, and for the wider field of regenerative medicine.
  Precision Medicine DTP - Time-resolved single-cell analysis of neural cell differentiation in motor neuron disease (MND)
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr C Sibley, Dr R Grima
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Motor neuron disease (MND) is a relentlessly progressing and devastating condition caused by the selective degeneration of upper and lower motor neurons essential for all movement.
  EPSRC InDustrial CDT for Offshore Renewable Energy (IDCORE)

Funding Type

PhD Type

A jointly awarded Doctorate in Engineering from the University of Edinburgh, Exeter University and Strathclyde University, offering ten places per year funded by the UK Engineering and Physical Sciences Research Council.
  Precision Medicine DTP - A step change in sensitivity of Raman spectroscopy for accurate and rapid analysis of living cells
  Dr A Downes, Dr H Yin
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Most methods of cell characterization require a destructive or invasive test, without any real-time readout.
  Precision Medicine DTP - Blood flow and solute transport in human placental vascular networks: an in-silico approach to characterising pregnancy pathologies
  Dr T Krueger, Dr M Bernabeu
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. The human placenta performs diverse functions later taken on by several different organs. In particular, it mediates the exchange of vital solutes, including respiratory gases and nutrients, between the mother and the developing fetus.
  Precision Medicine DTP - Determining clinically significant early stage lung cancers from image analysis
  Dr W.H. Nailon
Application Deadline: 8 January 2020

Funding Type

PhD Type

Additional Supervisors. Dr Iain Philipps, Dr Duncan Mclaren & Dr Stephen Harrow. Background. Stereotactic Ablative Body Radiotherapy (SABR) is an image guided radiotherapy technique, used to deliver a curative treatment for early stage lung cancer.
  Precision Medicine DTP - Developing Personalised Precision Medical Approaches for Paediatric Intensive Care through Data Informatics and Machine Learning on the Impact of Acute Clinical and Physiological Phenotypes on Outcome
  Dr J Escudero Rodriguez, Dr T Lo, Dr L Moss
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Routine clinical practice generates a large amount of data that is under-used for research and quality improvement[1].
  Precision Medicine DTP - Tumour exosome-functionalised magnetic nanoparticles for magnetic resonance imaging guided precision medicine and personalised breast cancer treatment
  Dr M Chen, Dr B Qian, Prof R Vellaisamy
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. One of the difficulties in cancer treatment is the tumour heterogeneity. Therefore, the conventional “one size fits all” approach and even the targeted therapeutics will not efficiently treat all cancer patients.
  Modelling the agriculture-deforestation interface in the Brazilian Amazon and Cerrado biomes
  Dr P Alexander
Application Deadline: 9 January 2020

Funding Type

PhD Type

Summary. Mathematical modelling will be used to understand the dynamics of land use change and agricultural intensification and deforestation related to beef cattle and soybean production in Brazil.
  Study History, Classics and Archaeology at the University of Edinburgh - funding opportunities available

Funding Type

PhD Type

Our School. The School of History, Classics and Archaeology at the University of Edinburgh is one of the great world centres for the study of the human past.
  Precision Medicine DTP - Analysis of intestinal metagenomes using ASAR
  Prof I Goryanin, Dr S Farrington, Prof M Dunlop
Application Deadline: 8 January 2020

Funding Type

PhD Type

Additional Supervisors. Dr Anatoly Sorokin & Dr Vidya Rajasekaran. Background. Understanding risk factors to Colorectal Cancer (CRC) can aid in its prevention.
  Precision Medicine DTP - Detection of novel prognostic macrophage-associated genes in cancer
  Dr D Oyarzun, Dr B Qian
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. The grand goal of precision medicine is to deliver the right treatment to the right person at the right time. Thanks to tremendous progress in omics technologies we can now access ever more detailed maps of the molecular make-up of patients.
  Precision Medicine DTP - Large-Scale Data-Driven Lung Cancer Diagnostics using Time-Resolved Fluorescence Spectroscopy (TRFS)
  Dr S Seth, Dr KD Dhaliwal, Dr M Khadem
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Pulmonary nodules are common, often incidental, findings on chest CT scans. The investigation of pulmonary nodules is, however, time-consuming and often leads to protracted follow-up with ongoing radiological surveillance.
  EPSRC InDustrial CDT for Offshore Renewable Energy (IDCORE)

Funding Type

PhD Type

A jointly awarded Doctorate in Engineering from the University of Edinburgh, Exeter University and Strathclyde University, offering ten places per year funded by the UK Engineering and Physical Sciences Research Council.
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