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protease PhD Projects, Programs & Scholarships

We have 15 protease PhD Projects, Programs & Scholarships

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  Protease-resistant antimicrobial peptides to target bacterial and fungal pathogens
  Dr J Bella, Dr L Tabernero
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance is quickly becoming a serious global health problem. The emergence of multidrug-resistant microbial strains combined with the drying up of the antibiotic pipeline in the pharmaceutical industry has significantly worsened the situation in recent years.
  Engineering protease-activated receptors to modulate cell signalling output
  Dr R Preston, Dr I Schoen
Application Deadline: 2 December 2019

Funding Type

PhD Type

Protease-activated receptor 1 (PAR1) is a G protein coupled-receptor expressed on the surface of endothelial cells and platelets.
  Investigating the role of the protease ADAMTS5 in ovarian cancer
  Dr E Rainero
Applications accepted all year round

Funding Type

PhD Type

Ovarian cancer is the most lethal gynaecological malignancy. Mostly because of late stage diagnosis, the 5-year survival rate is.
  Dissecting novel mechanisms of cysteine protease biology in tumourigenesis
  Dr R Burden, Prof C Scott
Applications accepted all year round

Funding Type

PhD Type

Proteases are known for their role in facilitating tumour development, primarily through processes such as proliferation and invasion.
  Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Prof P Loadman
Applications accepted all year round

Funding Type

PhD Type

Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis.
  Targeting antiretroviral drugs to the gut-associated lymphoid tissues for improved treatment of HIV/AIDS
  Dr P Gershkovich
Applications accepted all year round

Funding Type

PhD Type

"Gut-associated lymphoid tissue (GALT) is an anatomical reservoir of HIV, setting a barrier for strategies aimed at HIV eradication.
  Functional analysis of fungal effector proteins in the barley/wheat powdery mildew plant-pathogen interactions.
  Dr L Bindschedler, Prof A Devoto
Applications accepted all year round

Funding Type

PhD Type

Pathogens secrete small proteins called effectors or virulence factors which are important for the successful invasion of the host.
  Characterisation of DNA-protein crosslink proteolysis repair in cancer and therapy
  Prof K Ramadan, Prof B Kessler
Application Deadline: 4 December 2019

Funding Type

PhD Type

THE PROJECT. DNA-protein crosslinks (DPCs) are under-investigated DNA lesions caused by the covalent attachment of proteins to DNA.
  FGFR signalling in breast cancer
  Dr A Chioni
Applications accepted all year round

Funding Type

PhD Type

Growth factors are used during development to convey messages that tell cells to divide, survive, migrate and adopt a particular fate.
  Cryo-electron tomography of HIV-1 assembly and maturation
  Dr J Briggs
Application Deadline: 3 December 2019

Funding Type

PhD Type

Retroviruses are enveloped RNA viruses, whose assembly is largely driven by the viral Gag polyprotein. Gag recruits other virion components and targets them to the viral assembly site.
  Accurate energy evaluation of receptor-ligand interaction
  Prof P Popelier, Dr S De Visser
Applications accepted all year round

Funding Type

PhD Type

Drug design routinely uses existing computational methods to evaluate the interaction energy between receptor (protein) and ligand (drug) in molecular docking.
  (BBSRC DTP) Characterising the proteolytic network of plant cathepsin B
  Dr P Gallois, Dr A Day
Application Deadline: 31 January 2020

Funding Type

PhD Type

Programmed Cell Death (PCD) is a process that is critical to all organisms for development and defence against pathogens. The process of PCD in plants does not mirror what has been described in animal apoptosis and represents a novel alternative pathway still to be fully discovered.
  Cathepsin Z as a novel potential biomarker for osteoporosis
  Dr D Barraclough, Prof L Ranganath
Applications accepted all year round

Funding Type

PhD Type

Supervisors. Dr. Dong Barraclough, Professor Lakshminarayan Ranganath and Professor Sobhan Vinjamuri.
  Biological role of Stress Hormones
  Dr A B Bicknell
Applications accepted all year round

Funding Type

PhD Type

OVERVIEW. Our lab focuses on the biological roles of peptide hormones derived from pro-opiomelanocortin (POMC), a protein produced in the anterior pituitary gland.
  BBSRC White Rose DTP iCASE - Exploring the therapeutic potential of BoNT/X
  Dr A Peden
Application Deadline: 6 January 2020

Funding Type

PhD Type

Clostridial neurotoxins are produced by anaerobic bacteria such as Clostridium botulinum. Each toxin molecule has a highly conserved zinc-dependent protease domain that has exquisite specificity for SNARE proteins, a family of molecules required for intracellular trafficking and vesicle fusion.
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