protein aggregation PhD Projects, Programmes & Scholarships

Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Supervisors: Prof C M Grant, Prof M Ashe

Year round applications PhD Research Project Self-Funded PhD Students Only

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Assessing the Impact of Aggregation-Prone Proteins on the Mitochondrial-Metallome Interplay in a Novel 3D Spheroid Cholinergic Cell Model of Neurodegenerative Disease

University of Birmingham School of Biomedical Sciences

Although showing diverse symptoms affecting cognition and movement, the brains of patients with neurodegenerative disorders (NDs) display similar neuropathological features namely protein aggregation within the brain. Read more

Supervisors: Dr I Pienaar, Prof J.F. Collingwood

Year round applications PhD Research Project Self-Funded PhD Students Only

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Engineering Developable Biopharmaceuticals

University of Leeds Faculty of Biological Sciences

The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Supervisors: Prof D B Brockwell, Prof S E Radford

Open Day(s) Year round applications PhD Research Project Self-Funded PhD Students Only

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Protein self assembly induced by multivalent biological metabolites

The University of Manchester Department of Chemical Engineering

In addition to being an energy source in biological reactions, recent discoveries suggest adenosine triphosphate (ATP) also plays a critical role in maintaining cell stability and preventing deleterious cellular processes through modulating biomacromolecular self assembly. Read more

Supervisor: Dr R Curtis

31 December 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Exploring Synthetic Lethality Interactions through Targeting the SUMO Pathway for Therapeutic Insights

University of Leeds Faculty of Biological Sciences

The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Supervisor: Dr C Bassi

Open Day(s) Year round applications PhD Research Project Self-Funded PhD Students Only

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Applied optogenetics to study the influence of neuronal activity on neurodegeneration

Macquarie University Centre for MND Research

Neurodegenerative diseases represent a significant and growing challenge to global health, affecting millions worldwide. Despite extensive research efforts, the underlying mechanisms of neurodegeneration are not fully understood, and there is a critical lack of effective treatments. Read more

Supervisors: Assoc Prof MM Morsch, Prof RC Chung

30 September 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Investigating lysosomal (dys)function in ageing and neurodegeneration

University of Reading Department of Biomedical Sciences

Project Overview. Ageing is associated with a decline in the functions of an organism (López-Otín, C. et al. Cell, 2023) and correlates with an increased risk of developing diseases in the later life (Niccoli, T. Read more

Supervisors: Dr S Cogo, Dr E Kevei

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

University of Sheffield School of Biosciences

Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more

Supervisor: Dr C Guo

Year round applications PhD Research Project Self-Funded PhD Students Only

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How does the dynamic intra-membrane aggregation of phage lysis proteins kill bacterial pathogens?

The University of Manchester Department of Physics and Astronomy

This is an interdisciplinary project. It will provide a unique opportunity to obtain training in a wide range of interdisciplinary skills, including protein engineering techniques, protein purification, atomic force microscopy, neutron reflection and scattering as well as molecular dynamics simulations. Read more

Supervisor: Prof J Lu

28 June 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Fully Funded PhD Scholarship in Antibody Drug Conjugate (ADC) analysis by Polarized Excitation Emission Matric (pEEM) spectroscopy, NBL-3

University of Galway School of Natural Sciences

Application(s) are invited from suitably qualified candidates for full-time funded PhD scholarship(s) starting in February 2024 affiliated to the Nanoscale Biophotonics Laboratory in the Discipline of Physics (School of Natural Sciences) at the University of Galway. Read more

Supervisor: Prof AG Ryder

31 May 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Structure-function relationships governing polyphenol bioactivity with respect to plasma membranes

University of Reading Department of Food and Nutritional Sciences

This project aims to investigate polyphenol binding to lipid membrane surfaces with a view to understanding how polyphenol structure and aggregation within the gastrointestinal tract (GIT) affects the bioavailability of these nutraceuticals. Read more

Supervisors: Prof R A Frazier, Dr R Green

Year round applications PhD Research Project Self-Funded PhD Students Only

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Fully Funded PhD Scholarship in Polarised Fluorescence based Downstream Analytics, NBL-1

University of Galway School of Natural Sciences

Application(s) are invited from suitably qualified candidates for full-time funded PhD scholarship(s) starting in February 2024 affiliated to the Nanoscale Biophotonics Laboratory in the Discipline of Physics (School of Natural Sciences) at the University of Galway. Read more

Supervisor: Prof AG Ryder

31 May 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Genetics: Investigating the molecular basis of optic nerve degeneration in glaucoma to try and develop a personalized medicine strategy for treatment

University of Leeds Faculty of Medicine and Health

The optic nerve is a special sensory nerve that transmits visual impulses from the retina to the brain. Primary Open Angle Glaucoma (POAG) is a chronic, progressive optic neuropathy of multifactorial origin that affects 1 in 10 elderly individuals. Read more

Supervisor: Dr M Ali

Open Day(s) Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 13 protein aggregation PhD Projects, Programmes & Scholarships

protein aggregation PhD Projects, Programmes & Scholarships

We have 13 protein aggregation PhD Projects, Programmes & Scholarships

Chaperones and the response to protein misfolding stress

Assessing the Impact of Aggregation-Prone Proteins on the Mitochondrial-Metallome Interplay in a Novel 3D Spheroid Cholinergic Cell Model of Neurodegenerative Disease

Engineering Developable Biopharmaceuticals

Protein self assembly induced by multivalent biological metabolites

Exploring Synthetic Lethality Interactions through Targeting the SUMO Pathway for Therapeutic Insights

Applied optogenetics to study the influence of neuronal activity on neurodegeneration

Investigating lysosomal (dys)function in ageing and neurodegeneration

Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

How does the dynamic intra-membrane aggregation of phage lysis proteins kill bacterial pathogens?

Fully Funded PhD Scholarship in Antibody Drug Conjugate (ADC) analysis by Polarized Excitation Emission Matric (pEEM) spectroscopy, NBL-3

Structure-function relationships governing polyphenol bioactivity with respect to plasma membranes

Fully Funded PhD Scholarship in Polarised Fluorescence based Downstream Analytics, NBL-1

Genetics: Investigating the molecular basis of optic nerve degeneration in glaucoma to try and develop a personalized medicine strategy for treatment

We have 13 protein aggregation PhD Projects, Programmes & Scholarships

protein aggregation PhD Projects, Programmes & Scholarships

We have 13 protein aggregation PhD Projects, Programmes & Scholarships

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