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proteomic PhD Projects, Programs & Scholarships

We have 39 proteomic PhD Projects, Programs & Scholarships

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  A proteomic study of serum from children with neurofibromatosis type 1 autism
  Prof J Green, Dr S Garg, Dr R Unwin
Applications accepted all year round

Funding Type

PhD Type

Proteomic approaches using mass spectrometric analysis have proved a valuable tool in understanding the molecular pathogenesis of complex disorders such as schizophrenia and ASD.
  Activity based proteomic probes for profiling CYP2W1 in cancer tissues
  Research Group: Institute of Cancer Therapeutics
  Dr C Sutton, Dr K Pors
Applications accepted all year round

Funding Type

PhD Type

Cytochromes P450 (CYPs) are a superfamily of mixed function oxidases of which CYP1-4 subfamily members are unique in their ability to oxidise drugs.
  Proteomic Markers of Chronic Renal Scarring
  Dr P Watson
Applications accepted all year round

Funding Type

PhD Type

All types of chronic kidney disease (CKD) progress to end stage renal failure through a common pathway of fibrosis and scarring. Subsequently 2 million patients worldwide require renal replacement therapy (RRT).
  Elucidation of the role of newly discovered post-translational modification of proteins involved in hypoxia signalling using proteomic analysis and live cell imaging
  Dr V See, Prof C E Eyers
Applications accepted all year round

Funding Type

PhD Type

The hypoxia signalling pathway is required for the adaptation of cells to a low oxygen environment, which cells can experience in various physiological and pathological circumstances related to high altitude, development, wound healing and cancer.
  A functional proteomic approach to reveal how receptor tyrosine kinases trafficking specifies cancer cell responses
  Dr C Francavilla, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Background and goals. Cells respond appropriately to their surroundings by activating plasma membrane spanning receptors like Receptor Tyrosine Kinases (RTKs) and thereby adapting long-term outputs (e.g.
  Proteomic analyses of adhesion signalling in cancer
  Prof M J Humphries, Dr C Jorgensen
Applications accepted all year round

Funding Type

PhD Type

Why adhesion? Cell surface adhesion receptors play key roles in the control of cell movement, survival, division and differentiation, and they underpin a metazoan (multicellular) existence.
  Proteomic approach to understand mitochondrial quality control under normal and stress conditions
  Dr H Lu, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Defects in protein quality control lead to the accumulation of misfolded and damaged proteins, which play an important role in many diseases (e.g.
  The generation of RBCs in vitro from stem cell sources and the molecular regulation of erythropoiesis.
  Dr J Frayne
Applications accepted all year round

Funding Type

PhD Type

Development of systems for the generation of red blood cells (RBCs) from stem cells sources (adult peripheral blood, cord blood and pluripotent stem cells)…
  Assessment of the predictive value of plasma proteins in oesophageal adenocarcinoma treatment
  Dr AJ Stewart
Application Deadline: 19 July 2019

Funding Type

PhD Type

Applications are invited for a Tenovus Scotland PhD studentship to start in October 2019. The project will be supervised by Dr Alan Stewart, Dr Swati Arya and Dr Peter Caie in the School of Medicine.
  Impact of alternative mRNA splicing on the human proteome
  Dr V Wickramasinghe, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

Alternative splicing of RNA transcripts has emerged as a key mechanism for enabling biological complexity within the human genome.
  Characterising the skeletal muscle secretome and its role in cardiometabolic disease
  Dr Daniel Kelly, Dr D P Smith
Application Deadline: 30 June 2019

Funding Type

PhD Type

Faculty of Health & Wellbeing, Sheffield Hallam University. Biomolecular Sciences Research Centre. PhD Research Studentship (full-time for 3 years).
  Elucidating the interplay between mitochondrial dynamics, organelle contact sites and metabolic (re)programming (On the University’s application portal, please select "PhD in Medical Science at the MRC Mitochondrial Biology Unit").
  Dr J Prudent
Application Deadline: 30 June 2019

Funding Type

PhD Type

Mitochondria house hundreds of biochemical reactions involved in processes critical for the survival and homeostatic adaptation of the cell.
  Molecular mechanisms of neuronal ageing in bladder and bowel neurons (ref: SF18/APP/Ranson)
  Dr R Ranson
Applications accepted all year round

Funding Type

PhD Type

Ageing results in a progressive loss of physiological function resulting in a reduced quality of life in the elderly. One of the more prevalent conditions associated with ageing is incontinence-both faecal and urinary.
  Novel drug target validation for treating Diabetes Mellitus (ref: SF18/APP/Soundararajan)
  Dr M Soundararajan
Applications accepted all year round

Funding Type

PhD Type

The important cellular entities responsible for fighting against infections in our body are the T cells. T cells are however also shown to play a central role in the development of autoimmune diseases (AIDs) as “T cell activation hijacking” is the major autoimmune reaction causing mechanism observed in several AIDs.
  The role of isothiocyanates-derived from natural sources in uveal melanoma chemoprevention (ref: SF18/APP/McDermott)
  Prof A McDermott, Prof M Panagiotidis, Dr G Koutsidis
Applications accepted all year round

Funding Type

PhD Type

Uveal melanoma is the most frequent primary intraocular tumor, in Caucasian adults, and one that is very difficult to treat once it becomes metastatic.
  Functional analysis of fungal effector proteins in the barley/wheat powdery mildew plant-pathogen interactions.
  Dr L Bindschedler, Prof A Devoto
Applications accepted all year round

Funding Type

PhD Type

Pathogens secrete small proteins called effectors or virulence factors which are important for the successful invasion of the host.
  Determining the translational potential of the highly phosphorylated proto-oncogene PBF
  Dr V Smith
Applications accepted all year round

Funding Type

PhD Type

In order to translate the many molecular alterations now detectable in human tumours into effective clinical management we need to fully understand their impact on tumour biology.
  Determining brain glycosylation in ageing and Alzheimer’s disease
  Research Group: Pharmacology and Experimental Therapeutics
  Dr R Williamson, Dr C Sutton
Applications accepted all year round

Funding Type

PhD Type

Increasing age is associated with lower levels of cognitive performance; concomitant with this is a decrease in brain glucose metabolism.
  Exploration of 5-fluorouracil resistance mechanisms in colorectal cancer using 5-FU-resistant xenograft models
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Dr C Sutton
Applications accepted all year round

Funding Type

PhD Type

Despite therapeutic advances, colorectal cancer (CRC) still has a 45% mortality rate, and one of the major problems is the development of acquired resistance to treatment with anticancer drugs.
  Identifying glucose-dependent mechanisms underlying risk factors for Alzheimer’s disease
  Research Group: Pharmacology and Experimental Therapeutics
  Dr R Williamson, Dr S McLean
Applications accepted all year round

Funding Type

PhD Type

Several risk factors for Alzheimer’s disease including diabetes and midlife obesity are age-dependent and have an obvious metabolic component resulting in impaired glucose metabolism.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  LaNts and laminins in breast cancer
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

The laminins are a family of proteins that make up part of specialised regions of extracellular matrix termed basement membranes.
  Understanding bone mass using collageneases and aggrecanases
  Prof G Bou-Gharios
Applications accepted all year round

Funding Type

PhD Type

Bone is not only essential for locomotion, support and protection but crucial for many aspects of animal and human health. Specifically, bone is a calcium/phosphorous reservoir, is integral to glucose metabolism, houses the hematopoietic system and cross-talks with renal and reproductive systems.
  Bacteriophages of Gram positive bacteria: gateways to infection control
  Dr G Xia, Prof J P Derrick
Applications accepted all year round

Funding Type

PhD Type

The rise in antibiotic resistance has prompted a renewed interest in bacteriophage research. A study of the molecular basis for recognition of the bacterial host has applications in detection, vaccine design and control of bacterial infections.
  Genetic and immunological basis of rare primary immunodeficiency diseases
  Dr P Arkwright, Dr T Briggs, Prof T Hussell
Applications accepted all year round

Funding Type

PhD Type

Objective. To understand the genetic and explore the functional immune basis of rare primary immunodeficiency diseases. Background.
  Immune control of parasitic infection: Defining the role of gel-forming mucins in protection against gastrointestinal nematodes
  Prof D Thornton, Prof R K Grencis
Applications accepted all year round

Funding Type

PhD Type

Infection by gastrointestinal parasites (GI) is one of the most common types of parasitic infection in man and animals worldwide.
  Ion channel clustering in neuronal membranes
  Dr S M Prince, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

The aim of the study is to investigate the organization of ion channels in the membranes of excitable cells by scaffold proteins, and to discover how the properties of the channels are modified by these interactions.
  Membrane protein misfolding and disease: quality control pathways
  Dr L Swanton, Prof P Woodman
Applications accepted all year round

Funding Type

PhD Type

Misfolded proteins represent a continuous threat to cell viability, and if allowed to accumulate, can disrupt cellular function and induce cell death.
  Quantitative Allele-Specific Proteomics in Drug Metabolism and Disposition
  Dr J Barber, Dr B Achour, Prof A Rostami
Applications accepted all year round

Funding Type

PhD Type

The effective dose of a drug is subject to considerable inter-individual variation because the enzymes that metabolise drugs and the proteins that transport them in and out of cells exist, in many cases, in different polymorphic forms and are expressed in varying concentration.
  Understanding the aetiology of diabetic neuropathy
  Dr N Gardiner, Dr R Unwin
Applications accepted all year round

Funding Type

PhD Type

Diabetic neuropathy is a common secondary complication of diabetes mellitus which affects around 50% of all patients with diabetes - impacting on health, wellbeing and quality of life.
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