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recombinant PhD Projects, Programs & Scholarships

We have 74 recombinant PhD Projects, Programs & Scholarships

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  Modelling cellular stress during recombinant protein production for improving upstream biomanufacturing processes
  Dr D Dikicioglu, Prof G Lye
Application Deadline: 29 November 2019

Funding Type

PhD Type

Applications are invited for one PhD studentship to work in modelling the stress imposed on host organisms by recombinant protein production for improving predictive capabilities of upstream bioprocess models employed in biomanufacturing practices.
  Cross presentation of antigens of recombinant overlapping peptides to optimise vaccines against tumour and infectious diseases
  Dr S Jiang, Dr N Burgess-Brown
Application Deadline: 4 December 2019

Funding Type

PhD Type

THE PROJECT. We have developed a technology to producing overlapping peptides - bacterial expression of an amino acid sequence corresponding to overlapping peptide sequences spanning the length of a protein of interest interspersed with enzymatic cleavage sites.
  Oxidative protein folding of industrially and pharmaceutically important recombinant proteins
  Dr H Lu, Dr A Day
Applications accepted all year round

Funding Type

PhD Type

Oxidative protein folding is an important process for the function of many proteins, which includes both folding and formation of native disulphide bonds.
  In silico design of high-affinity recombinant antibodies
  Dr P Mulheran, Dr V A Ferro
Application Deadline: 30 November 2019

Funding Type

PhD Type

Currently there is a trend to move from small drug molecule therapy to use of biologics such as monoclonal antibodies (mAb).
  Developing a virus-like particle (VLP) Polio vaccine
  Dr G Mulley
Applications accepted all year round

Funding Type

PhD Type

Rationale. Poliovirus is a non-enveloped RNA virus, spread via the faecal-oral route, that causes the infectious disease Poliomyelitis (Polio).
  Identifying Dengue virus receptor proteins in Aedes aegypti mosquito
  Dr A Winter
Applications accepted all year round

Funding Type

PhD Type

Neglected tropical diseases caused by the Dengue virus (DENV), endemic Dengue fever and its more severe manifestation, Dengue syndrome, cause great socioeconomic loss as well as high mortality in Asia and South America.
  Engineering protease-activated receptors to modulate cell signalling output
  Dr R Preston, Dr I Schoen
Application Deadline: 2 December 2019

Funding Type

PhD Type

Protease-activated receptor 1 (PAR1) is a G protein coupled-receptor expressed on the surface of endothelial cells and platelets.
  Rational engineering of NMDAR subunit-specific peptide affinity reagents and their pharmacological and functional characterisation as novel subtype specific NMDAR ligands.
  Dr M Soloviev
Applications accepted all year round

Funding Type

PhD Type

The aim of this project is to engineer subunit-specific anti-GluN1/2/A/B polypeptide affinity reagents and to characterise their pharmacological specificity and functional activity on the recombinant NMDARs expressed in heterologous expression systems and on native NMDARs in hippocampal slice preparations.
  (BBSRC DTP) Engineering novel stress-resilient microalgae strains as improved platform strains for industrial biotechnology
  Dr J Pittman, Dr P Gallois, Dr A Day
Application Deadline: 31 January 2020

Funding Type

PhD Type

Microalgae have potential as photosynthetic cell factories for the production of chemicals and metabolites that can be used for industrial applications or as platform strains for the production of recombinant proteins.
  EASTBIO: Understanding the pathogenesis of life-threatening Burkholderia cenocepacia infections using blocking antibodies and novel chemistry scaffolds to untangle complex aspects of AMR
  Prof A Porter, Dr S Palliyil, Prof M Jaspars
Application Deadline: 5 January 2020

Funding Type

PhD Type

Supervisors. Professor Andy Porter (University of Aberdeen). https://www.abdn.ac.uk/people/a.porter. Dr Soumya Palliyil (University of Aberdeen).
  Development of functionalised exosomes for personalised precision medicine in the treatment of cancer - a nanomedicine platform
  Research Group: Biomedical Research Group
  Dr P Dyer, Dr C O'Kane, Prof C Parris
Applications accepted all year round

Funding Type

PhD Type

Research Group. Biomedical Research Group. https://www.anglia.ac.uk/science-and-engineering/research/institutes-and-groups/biomedical.
  The investigation of a novel peptide delivery platform for the manipulation of platelet function
  Research Group: Biomedical Research Group
  Dr P Dyer, Dr N Pugh
Applications accepted all year round

Funding Type

PhD Type

Research Group. Biomedical Research Group. https://www.anglia.ac.uk/science-and-engineering/research/institutes-and-groups/biomedical.
  Antibody-drug conjugates (ADCs) for the treatment of solid tumours
  Dr S Karagiannis, Prof J Downward
Application Deadline: 29 November 2019

Funding Type

PhD Type

An Antibody-Drug Conjugate (ADC) comprises an antibody targeted toward a tumour cell surface antigen, coupled through a chemical linker to a highly-cytotoxic drug.
  Development of nature-inspired polyester particles for cancer vaccines
  Prof Bernd Rehm
Applications accepted all year round

Funding Type

PhD Type

Advances in synthetic biology allows recombinant bacteria to produce protein coated polyester particles. These polyester particles have been utilized as particulate vaccines against bacterial and viral infections.
  Rheological and mechanical behaviour of fibre composite with nanobiocomposites matrix for aerospace applications
  Dr S Vahid
Applications accepted all year round

Funding Type

PhD Type

The applications of nanocomposite materials derived from natural biopolymer components gaining more attraction because of their renewability, biodegradability, flexibility, and their capability of novel functionalities.
  Investigating the Drosophila DF31 protein to gain insight into the mechanisms and chromatin maintenance in animal cells
  Dr S Cotterill, Dr A Nohturfft
Applications accepted all year round

Funding Type

PhD Type

The Drosophila DF31 protein is an abundant ribonucleoprotein that localises to euchromatic regions and is involved in maintaining chromosome structure.
  (BBSRC DTP) Mechanism of early steps in protein synthesis by cryoEM imaging of supramolecular complexes
  Dr A Roseman, Prof G D Pavitt, Prof C Baldock
Application Deadline: 31 January 2020

Funding Type

PhD Type

The aim of this project is to understand the mechanism and control of protein synthesis in eukaryotic cells at the molecular level, particularly focused around the role of the eukaryotic translation initiation factors eIF2, eIF5 and eIF2B.
  (BBSRC DTP) Understanding structure and function of the mechanosensors talin and vinculin
  Dr C Ballestrem, Prof C Baldock, Dr A Roseman
Application Deadline: 31 January 2020

Funding Type

PhD Type

The ability of cells to sense biochemical and mechanical properties of their extracellular matrix (ECM) environment is critical for the development of functional tissue.
  Cutting off the fuel supply to calcium pumps in pancreatic cancer: a novel therapeutic strategy
  Dr J Bruce, Prof K Williams, Dr A P Gilmore
Applications accepted all year round

Funding Type

PhD Type

Background and Rationale. Pancreatic ductal adenocarcinoma (PDAC) has the poorest survival and limited treatment options. Therefore, the search for novel therapeutic targets and drugs designed to selectively kill PDAC cells must remain a central research strategy.
  Protease-resistant antimicrobial peptides to target bacterial and fungal pathogens
  Dr J Bella, Dr L Tabernero
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance is quickly becoming a serious global health problem. The emergence of multidrug-resistant microbial strains combined with the drying up of the antibiotic pipeline in the pharmaceutical industry has significantly worsened the situation in recent years.
  Stress regulation of protein translation: role in cancer and neurodegeneration
  Dr A J Whitmarsh, Prof M Ashe
Applications accepted all year round

Funding Type

PhD Type

Cells are subjected to a range of stresses that include physical injury, changes in oxygen levels or temperature, nutrient deprivation, radiation and infection.
  Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
  Prof A Sharrocks, Prof M Rattray
Applications accepted all year round

Funding Type

PhD Type

Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity.
  Structure/function studies of component proteins of anti-feeding prophage (Afp), a bacteriophage tail-like particle using high-resolution cryo-EM and x-ray crystallography
  Prof A Mitra
Applications accepted all year round

Funding Type

PhD Type

We are seeking a highly motivated candidate to carry out structure/function studies of component proteins of anti-feeding prophage (Afp), a bacteriophage tail-like particle using high-resolution cryo-EM and x-ray crystallography.
  GW4 BioMed MRC DTP PhD studentship: Structure of ART Toxins: understanding toxicity through host receptor interactions
  Prof R Mrsny, Dr G Masuyer
Application Deadline: 25 November 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the ‘GW4 BioMed MRC Doctoral Training Partnership’ which is offering up to 18 studentships for entry in September 2020.
  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Applications accepted all year round

Funding Type

PhD Type

Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  ADDomer: Synthetic Multiepitope Virus-Like Particle Platform for Next-Generation Vaccines
  Prof I Berger
Application Deadline: 2 December 2019

Funding Type

PhD Type

Infectious diseases plague and decimate populations. Among the means at our disposal to counter this threat, vaccination has proven to be exceptionally powerful.
  How does the protein LicB underpin infection by opportunistic bacteria?
  Dr P Curnow
Application Deadline: 25 November 2019

Funding Type

PhD Type

The human body is colonized by trillions of bacteria. These are generally harmless but can become a serious threat to human health.
  Precision Genome Editing using Modulators of dsDNA Break Repair Pathways
  Prof C Berger-Schaffitzel
Application Deadline: 2 December 2019

Funding Type

PhD Type

CRISPR/Cas9 relies on introducing specific double-stranded DNA breaks (DSBs) into the target genome which are then repaired by the predominant host cell DSB repair mechanisms.
  Taking de novo protein design and assembly into bacterial cells
  Prof DN Woolfson, Prof N J Savery, Prof P Verkade
Application Deadline: 2 December 2019

Funding Type

PhD Type

De novo protein design is said to have come of age (Huang et al., (2016) Nature 537 320). This is because a wide variety of synthetic protein structures can now be made from scratch, i.e., from first principles, or by applying computational design.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
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