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splicing PhD Projects, Programmes & Scholarships

We have 22 splicing PhD Projects, Programmes & Scholarships

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Structural investigation of oncogenic splicing factors

University of Leicester Molecular and Cell Biology
More than 90% of human genes can and do express multiple proteins. This is achieved by a process called alternative RNA splicing, which is an essential step in gene expression in mammals. Read more
 Supervisors: Dr C Dominguez, Prof I Eperon, Prof A Hudson
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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A deep-learning approach to genomic regulation of tissue-specific alternative splicing

The University of Manchester Faculty of Biology, Medicine and Health
Each human gene is a blueprint for multiple distinct RNA transcripts that can be produced in differing quantities based on the localisation of the transcribing… Read more
 Supervisors: Dr JE Eales, Prof T Papamarkou
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Identifying variants impacting splicing of 5’ and 3’ UTRs and underpinning inherited retinal disease

The University of Manchester Faculty of Biology, Medicine and Health
Genomic variation that impacts splicing is well established as a cause of genomic disorders, but is almost exclusively limited to protein-coding exons and introns intersecting protein-coding exons. Read more
 Supervisors: Dr J Ellingford, Prof R O'Keefe
 15 June 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Understanding the role of spliceosome gene mutations in disease

The University of Manchester Faculty of Biology, Medicine and Health
The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more
 Supervisors: Prof R O'Keefe, Prof B Newman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam

University of Birmingham School of Biosciences
Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more
 Supervisor: Dr M Soller
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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How do RNA-binding proteins control splice site selection? A multi-disciplinary approach

University of Leicester Molecular and Cell Biology
Almost every protein-coding gene in vertebrates can and does express multiple proteins. This is achieved primarily by RNA splicing, which is an essential step in gene expression in mammals and generates incredible diversity. Read more
 Supervisors: Prof I Eperon, Prof A Hudson, Dr C Dominguez
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Therapeutic resolution of Myelodysplastic Syndrome (MDS) by natural products

University of Bradford Faculty of Life Sciences
  Research Group: Pharmacology and Experimental Therapeutics
Myelodysplastic syndromes (MDS) are a type of blood cancer where the patients do not have enough healthy blood cells. Read more
 Supervisors: Dr T Nasim, Dr M Najafzadeh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Non-canonical functions of SRSF protein kinase (SRPK) in pluripotent stem cells

University of Dundee School of Life Sciences
The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. Read more
 Supervisor: Dr G Findlay
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Molecular characterization of Sam68-driven cytoskeletal reorganization

University of Leicester Molecular and Cell Biology
The cytoskeleton is a complex network of various fibres (microtubules, actin, …) that is essential for cells to maintain their shape and internal organization and for their migration. Read more
 Supervisors: Dr C Dominguez, Prof A Fry
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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MSc By Research: Understanding the mechanism of an essential nematode gene expression process

Aberdeen University School of Medicine, Medical Sciences & Nutrition
The MSc by Research programme at the University of Aberdeen is for students interested in a research-intensive master's degree. It is designed specifically to enhance your skills for a PhD or research career. Read more
 Supervisors: Prof J Pettitt, Dr B Mueller
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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BARIToNE: Improving barley climate resilience using a candidate gene approach (Project code 24H)

The James Hutton Institute PhD Opportunities
Supervisors. Lead supervisor - Dr Martin Balcerowicz, University of Dundee. Second supervisor - Dr Craig Simpson, James Hutton Institute. Read more
 Supervisors: Dr M Balcerowicz, Dr C Simpson, Ms G MacDonald
 31 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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BARIToNE: Improving barley climate resilience using a candidate gene approach (Project code 24H)

University of Dundee School of Life Sciences
Supervisors. Lead supervisor - Dr Martin Balcerowicz, University of Dundee. Second supervisor - Dr Craig Simpson, James Hutton Institute. Read more
 Supervisors: Dr M Balcerowicz, Dr C Simpson, Ms G MacDonald
 31 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Using genome sequencing to find the cause of undiagnosed rare conditions affecting bowel, heart, lung or brain in adults

University of Sheffield School of Medicine and Population Health
In the UK, a rare condition is one that affects fewer than 1/2000 people. Around 70% of rare conditions have a genetic cause (ie are caused by a change… Read more
 Supervisor: Dr A McNeill
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Therapeutic resolution of coronavirus (COVID-19) diseases by natural products

University of Bradford Faculty of Life Sciences
  Research Group: Pharmacology and Experimental Therapeutics
Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more
 Supervisor: Dr T Nasim
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: m6A modification of segmentation clock mRNAs and its role in somitogenesis

University of Dundee School of Life Sciences
During early embryogenesis, segments (somites) are formed during a process called somitogenesis. These somites will go on to form the bones and muscles of the skeleton. Read more
 Supervisors: Prof J K Dale, Dr P Murray
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Molecular Analysis of Nuclear Bodies and RNP Trafficking Pathways in the Cell Nucleus

University of Dundee School of Life Sciences
Many important processes within mammalian cells are compartmentalised within specific subcellular structures. In the cell nucleus, Nuclear Bodies (NBs), such as nucleoli, provide specialised compartments that are not surrounded by membranes, but still concentrate specific proteins and RNAs. Read more
 Supervisor: Prof A I Lamond
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Genetic causes of novel neurodevelopmental disorders

University of Otago Department of Biochemistry
The Rare Disorder Genetics / Bicknell lab is interested in characterising novel genetic syndromes, with three core motivations. -the difference we can make to families with rare disorders, through providing them with more information. Read more
 Supervisor: Assoc Prof L Bicknell
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Novel disease genes in brain development and decline

University of Otago Department of Biochemistry
The Rare Disorder Genetics / Bicknell lab is interested in characterising novel genetic syndromes, with three core motivations. -the difference we can make to families with rare disorders, through providing them with more information. Read more
 Supervisor: Assoc Prof L Bicknell
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Exploring a novel neurodevelopmental disease gene using a zebrafish model

University of Otago Department of Biochemistry
The Rare Disorder Genetics / Bicknell lab is interested in characterising novel genetic syndromes, with three core motivations. -the difference we can make to families with rare disorders, through providing them with more information. Read more
 Supervisor: Assoc Prof L Bicknell
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis

Masaryk University Faculty of Medicine
Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development. Read more
 Supervisor: Dr D Blažek
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Functional Mechanisms of Genetic Risk Factors for Immune-Related Disease

King’s College London School of Medicine
Who are we?. Read more
 Supervisor: Prof T Vyse
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Transcriptome homeostasis in cellular ageing and cancer

Queen Mary University of London Institute of Dentistry
Project Summary. We have previously established the oncogenic mechanisms of the transcription factor FOXM1 in perturbation of genome stability (1, 2), epigenome (3, 4) and adult progenitor epithelial stem cell proliferation (5). Read more
 Supervisor: Dr M T Teh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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