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transcription PhD Projects, Programmes & Scholarships

We have 75 transcription PhD Projects, Programmes & Scholarships

Understanding transcription factor complexes controlling endothelial cell quiescence and escape from quiescence

University of Nottingham Division of Cancer and Stem Cells

Endothelial cell proliferation and lymphatic cell proliferation is initiated during angiogenesis and lymphangiogenesis respectively and are both regulated by the VEGF signalling pathway. With some exceptions, endothelial and lymphatic cells in healthy individuals are quiescent and do not proliferate. Read more

Supervisors: Dr S Jayaraman , Prof K Gaston, Dr AB Benest

Year round applications PhD Research Project Self-Funded PhD Students Only

Understanding transcription factor complexes in endothelial quiescence

University of Nottingham Division of Cancer and Stem Cells

Endothelial cell proliferation and lymphatic cell proliferation known as angiogenesis and lymphangiogenesis respectively are both regulated by ligands in the VEGF signalling pathway. Read more

Supervisors: Dr S Jayaraman , Prof K Gaston, Dr AB Benest

Year round applications PhD Research Project Self-Funded PhD Students Only

Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia

University of Liverpool Institute of Systems, Molecular and Integrative Biology

This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more

Supervisors: Dr M Papamichos Chronakis, Prof D MacEwan, Dr A Kanhere

Year round applications PhD Research Project Self-Funded PhD Students Only

ROLE OF FOXO1 TRANSCRIPTION FACTOR IN B-CELL MALIGNANCIES

Masaryk University Faculty of Medicine

The project is focused on FoxO1 transcription factor and its role in the pathophysiology of chronic lymphocytic leukemia (CLL). Although the therapy of CLL has made several remarkable improvements, the disease still remains incurable. Read more

Supervisor: Assoc Prof Marek Mraz

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis

Masaryk University Faculty of Medicine

Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. Read more

Supervisor: Dr D Blažek

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Understanding control of genome folding by cohesin

University of Leicester Molecular and Cell Biology

Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more

Supervisors: Prof D Panne, Dr T Schalch

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

Human Genetics, Genomics and Disease: Integrating fusion-proteins molecular signatures for advancing sarcoma diagnosis and therapy

University of Edinburgh College of Medicine and Veterinary Medicine

Research Group: MRC Human Genetics Unit

Location. MRC Human Genetics Unit, University of Edinburgh, UK & Max Delbrück Center, Berlin, Germany. Supervisors. Dr Nezha Benabdallah, Dr Daria Bunina. Read more

Supervisor: Dr NB Benabdallah

19 May 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

Structural insights into genome control by cohesin

University of Leicester Molecular and Cell Biology

Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more

Supervisor: Prof D Panne

Year round applications PhD Research Project Self-Funded PhD Students Only

Transcriptional kinases in cancer and developmental disorders

University of Leicester Molecular and Cell Biology

Cyclin-dependent kinases (CDKs) are protein kinases performing essential functions in regulation of cell cycle and transcription. Read more

Supervisor: Dr MT Tellier

Year round applications PhD Research Project Self-Funded PhD Students Only

Haematology: Oncogenic mechanisms causing malignant transformation of B cells and plasma cells

University of Leeds Faculty of Medicine and Health

Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Read more

Supervisor: Prof U Klein

Year round applications PhD Research Project Self-Funded PhD Students Only

Nuclear and transcriptional dysregulations during cellular senescence

University of Leicester Molecular and Cell Biology

Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more

Supervisors: Dr MT Tellier, Dr Y Markaki

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

PhD studentship - Defining the mechanisms underpinning HIF-1 and HIF-2 dependent transcriptional specificity in hypoxia.

Newcastle University Biosciences Institute

Award summary. 100% of home tuition fees paid and annual living expenses of £18,622. Overview. The cellular response to low oxygen levels (hypoxia), is crucial for cell survival and identity. Read more

Supervisor: Dr B Ortmann

14 June 2024 PhD Research Project Funded PhD Project (European/UK Students Only)

Understanding the evolution of gene regulatory networks through biophysical modelling and machine learning

The University of Manchester Faculty of Biology, Medicine and Health

The ability to coordinate the expression of genes within a cell is at the heart of life. When and how much of a specific gene is turned into a protein is essential for organisms to respond to their environment and to manage resources. Read more

Supervisors: Dr M Lagator, Prof M Rattray

Year round applications PhD Research Project Self-Funded PhD Students Only

Delineating the IRF6 regulatory network driving periderm formation and function

The University of Manchester Faculty of Biology, Medicine and Health

During development, the ectoderm passes through a series of cell states to produce a self-replenishing, multi-layered epidermis. Initial stratification forms a single-cell layer of flattened periderm cells which act as a barrier to prevent pathological adhesions during embryogenesis. Read more

Supervisors: Prof M Dixon, Dr J Dixon

Year round applications PhD Research Project Self-Funded PhD Students Only

Molecular mechanism of vimentin induced epithelial mesenchymal transition (EMT) and stemness in cancer cells

Queen Mary University of London Institute of Dentistry

Background. Most cancers are epithelial in origin and arise from a single progenitor cell, similar to an embryo, to become a clone of cells. Read more

Supervisors: Prof A Waseem, Dr H Tummala, Dr F Flores-Borja

Year round applications PhD Research Project Self-Funded PhD Students Only

The Survivin Interactome in Health and Disease

University of Nottingham School of Life Sciences

Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more

Supervisor: Dr S Wheatley

Year round applications PhD Research Project Self-Funded PhD Students Only

Short and long-term genetic and behavioural consequences of traumatic brain injury in fruit flies

University of Leicester Department of Genetics and Genome Biology

General background . How many fingers am I holding up? What day of the week is it? Follow my finger? These three questions are designed to test your sensory, memory and motor neural abilities following an accident; all three systems are affected by a severe deceleration of your brain. Read more

Supervisors: Dr B Warren, Dr E Rosato, Dr R Feuda

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

The University of Manchester Faculty of Biology, Medicine and Health

Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more

Supervisors: Dr S Nagarajan, Dr HH Harrison, Prof R Clarke, Dr I Iqbal

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

Dissecting mechanisms that control adult stem cells in health, disease, and ageing

University of Birmingham Institute of Cancer and Genomic Sciences

Research interests/description of main research theme. Read more

Supervisors: Dr M Clarke, Prof J Frampton

Year round applications PhD Research Project Self-Funded PhD Students Only

The role of NFIA fusion genes in erythroid leukaemia

Cardiff University Cardiff School of Medicine

It is clear that the process of haematopoietic (blood) development is ultimately coordinated by transcription factors, a view supported by the prevalence of transcription factor abnormalities found in leukaemia. Read more

Supervisor: Prof A Tonks

3 May 2024 PhD Research Project Funded PhD Project (European/UK Students Only)

BARIToNE: Improving barley climate resilience using a candidate gene approach (Project code 24H)

The James Hutton Institute PhD Opportunities

Supervisors. Lead supervisor - Dr Martin Balcerowicz, University of Dundee. Second supervisor - Dr Craig Simpson, James Hutton Institute. Read more

Supervisors: Dr M Balcerowicz, Dr C Simpson, Ms G MacDonald

31 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

BARIToNE: Improving barley climate resilience using a candidate gene approach (Project code 24H)

University of Dundee School of Life Sciences

Supervisors. Lead supervisor - Dr Martin Balcerowicz, University of Dundee. Second supervisor - Dr Craig Simpson, James Hutton Institute. Read more

Supervisors: Dr M Balcerowicz, Dr C Simpson, Ms G MacDonald

31 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

Investigating the role of RNA dependent DNA repair in childhood cancer

University of Dundee School of Medicine

Damage to our genetic material DNA is responsible for a wide range of human diseases including neurodegenerative diseases, haematological diseases, immune deficiencies, early ageing and cancers. Read more

Supervisor: Prof K Hiom

30 June 2024 PhD Research Project Self-Funded PhD Students Only

The role of regulatory evolution in phage ecology

The University of Manchester Faculty of Biology, Medicine and Health

The regulation of genes crucially determines the fitness and function of all organisms. This is particularly relevant for bacteriophages, the viruses that infect bacteria, as they rely on a tightly scheduled program for a successful infection. Read more

Supervisors: Dr M Lagator, Dr CI Igler

Year round applications PhD Research Project Self-Funded PhD Students Only

Cell-biological mechanisms mediating primary cilium mediated interpretation of Shh signalling during vertebrate neuronal differentiation

The University of Manchester Faculty of Biology, Medicine and Health

Newborn neurons undergo extensive morphological changes as they polarise to extend axons. In the developing spinal cord, newborn neurons extend axons towards their targets in response to cues from the surrounding tissues. Read more

Supervisors: Dr R Das, Dr S Herbert

Year round applications PhD Research Project Self-Funded PhD Students Only

Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis

Masaryk University Faculty of Medicine

Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development. Read more

Supervisor: Dr D Blažek

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

The analysis of HIF function in DNA repair and genome stability

University of Sheffield School of Biosciences

DNA damage is a factor that underlies many human diseases. Such damage results in mutations, and if such genetic alterations occur in tumour suppressor or proto-oncogenes it can lead to cancer. Read more

Supervisors: Dr F Van Eeden, Prof S El-Khamisy

Year round applications PhD Research Project Self-Funded PhD Students Only

Retrotransposons in immunity

UNSW Sydney School of Biotechnology and Biomolecular Sciences

Only about 1-2% of our genome is made up of protein coding genes, the rest is non-coding and at least half of that is made up of repetitive DNA sequences known as transposable elements (TEs). Read more

Supervisor: Prof C King

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

Transcriptome homeostasis in cellular ageing and cancer

Queen Mary University of London Institute of Dentistry

Project Summary. We have previously established the oncogenic mechanisms of the transcription factor FOXM1 in perturbation of genome stability (1, 2), epigenome (3, 4) and adult progenitor epithelial stem cell proliferation (5). Read more

Supervisor: Dr M T Teh

Year round applications PhD Research Project Self-Funded PhD Students Only

Mechanisms controlling gene expression in hypoxia and inflammation

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Oxygen is one of the most important molecules for life. Every member of the animal kingdom depends on oxygen to help metabolize its food and drive many critical processes in metabolism. Read more

Supervisor: Prof S Rocha

Year round applications PhD Research Project Self-Funded PhD Students Only

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