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transgenic PhD Projects, Programs & Scholarships

We have 42 transgenic PhD Projects, Programs & Scholarships

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  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Applications accepted all year round

Funding Type

PhD Type

Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  LaNts in wound repair, stem cell activation and squamous cell carcinoma
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

The Laminin N terminus proteins (LaNts) are a relatively unstudied protein family that are related to netrins and laminins. To date there are only two publications and one preprint about the LaNt proteins in the literature which means there is a massive potential to do novel, ground breaking research in this area.
  (MRC DTP) Investigating the role of neuroinflammation and cholesterol metabolism in the progression of brain injury following intracerebral haemorrhage
  Dr P Kasher, Dr D Brough, Prof S Allan, Dr A Parry-Jones
Application Deadline: 15 November 2019

Funding Type

PhD Type

Intracerebral haemorrhage (ICH) is a type of stroke caused by spontaneous bleeding within the brain.
  Targeting Notch signaling to treat osteoarthritis pain. (#202012)
  Prof T Vincent, Dr A Kusumbe
Application Deadline: 31 December 2019

Funding Type

PhD Type

Pain is the principal problem for thousands of individuals who suffer from osteoarthritis (OA), the most common form of joint disease.
  PhD position/Graduate Research Assistantship in the area of Allergy, Asthma and Immunology
  Dr A Mishra
Application Deadline: 14 March 2020

Funding Type

PhD Type

The Laboratory of Lung Inflammation, Department of Pathobiology, College of Veterinary Medicine at Auburn University have opening for highly motivated PhD candidate/ Graduate Research Assistant to work on NIH-funded research project in the area of Allergy, Asthma and Immunology.
  Egr2 and 3 mediated T cell tolerance in cancer and their impact in immune checkpoint therapy
  Dr S Li
Applications accepted all year round

Funding Type

PhD Type

Tumour infiltrated lymphocytes (TILs) contain tumour reactive T cells and have been used as adoptive cell transfer therapy in patients which can mediate cancer regression.
  Can improved genetic understanding of grain weight help feed the world? (UAUYJ20DTP)
  Dr C Uauy
Application Deadline: 25 November 2019

Funding Type

PhD Type

Wheat provides 20% of the calories and protein consumed by humans. The world population will reach 9 billion by 2050, which requires food production to more than double.
  How does epithelial tissue organization modulate pluripotent stem cell identity and fate?
  Dr M Shahbazi
Application Deadline: 3 December 2019

Funding Type

PhD Type

During embryogenesis pluripotent stem cells give rise to all the cell types present in the organism. How pluripotent cells decide their fate is a fundamental question in development and regeneration.
  Cellular cross-talk at the perivascular niche and the blood brain barrier
  Prof B Hogan
Applications accepted all year round

Funding Type

PhD Type

Much research on vasculature has focussed on the endothelial cells that line functional vessels, however the milieu of cells that surround vessels (mural cells) play important and under-appreciated roles in homeostasis and disease.
  The Hippo pathway and Yap1 in vascular growth control in development and disease
  Prof B Hogan, Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Lymphatic vessels play roles in the drainage of tissue fluid, trafficking of immune cells and the metastatic spread of cancer.
  Development of gene therapies for muscular dystrophies
  Dr L Popplewell
Applications accepted all year round

Funding Type

PhD Type

The activities in the Popplewell lab focus on the development of pre-clinical gene therapies for neuromuscular diseases, in particular muscular dystrophies based on gene replacement, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene sliencing.
  Interneuron Development in the Zebrafish Spinal Cord
  Dr K Lewis
Applications accepted all year round

Funding Type

PhD Type

The Lewis Lab moved to Syracuse University from Cambridge University in the UK in 2010.
  Early detection of colorectal cancer
  Dr V Li
Application Deadline: 12 November 2019

Funding Type

PhD Type

This 4-year PhD studentship is offered in Dr Vivian Li’s Group based at the Francis Crick Institute (the Crick).
  (MRC DTP) Innate immune crosstalk and orchestration of mucosal immunity
  Dr M Hepworth, Prof A MacDonald
Application Deadline: 15 November 2019

Funding Type

PhD Type

Barrier tissue sites - including the gastrointestinal tract, lung and skin – are the primary site of exposure to a multitude of foreign organisms and environmental challenges.
  (MRC DTP) Location, Location, Location: The importance of the immunological landscape during parasitic infection
  Prof R K Grencis, Dr K Couper
Application Deadline: 15 November 2019

Funding Type

PhD Type

Whipworm infection is one of the three major types of parasitic helminth infections of man, infecting one in fifteen of the world’s population.
  (MRC DTP) The importance of 24h rhythms in the gut microbiome for immunity
  Dr J Gibbs, Dr M Hepworth, Prof K Else
Application Deadline: 15 November 2019

Funding Type

PhD Type

The gut microbiome is a collection of trillions of organisms. These bacteria and the metabolites they produce (through the breakdown of dietary components) play a critical role in the maintenance of immunity.
  (MRC DTP) The role of the brain glymphatic system in recovery from cerebral malaria
  Dr K Couper, Dr D Brough, Dr M Fergie
Application Deadline: 15 November 2019

Funding Type

PhD Type

Cerebral malaria is a severe complication of Plasmodium falciparum infection that affects 2 -3 million people, resulting in approximately 300,000 deaths, each year.
  Function of miRNAs in formation and regeneration of human hair follicles
  Dr S Kurinna, Dr S Herrick, Prof R Paus
Applications accepted all year round

Funding Type

PhD Type

Recent advances in treating a severe skin condition with autologous transgenic keratinocyte cultures emphasises the importance of molecular mechanisms in selecting subpopulations of skin cells for cutaneous repair [1].
  Generation of transplant tissue following correction of patient stem cells by genomic engineering
  Dr F Manson, Dr RL Taylor, Dr A Adamson
Applications accepted all year round

Funding Type

PhD Type

A number of retinal degenerations result from mutations in genes expressed in the retinal pigment epithelium (RPE) which lies under the photoreceptors.
  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
  Dr M Harte, Prof J Neill
Applications accepted all year round

Funding Type

PhD Type

Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
  GW4 FRESH CDT PhD Studentship: Speciation of emerging contaminants in wetland systems
  Prof B Kasprzyk-Hordern
Application Deadline: 16 December 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the NERC Centre for Doctoral Training in Freshwater Biosciences and Sustainability (GW4 FRESH CDT) which is offering up to 14 studentships to start in September 2020.
  Regulation of autophagy in human embryonic stem cells and its therapeutic application in induced pluripotent stem cell-based disease models
  Dr S Sarkar
Applications accepted all year round

Funding Type

PhD Type

Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
  PhD Position in Molecular and Cellular Mechanisms of Synaptopathies/cerebellar motor dysfunction
  Prof S Schoch, Prof D Dietrich
Applications accepted all year round

Funding Type

PhD Type

A PhD Position in Molecular and Cellular Mechanisms of Synaptopathies/cerebellar motor dysfunction is available at the Institute of Neuropathology, University Bonn Medical School, Germany.
  PhD Position in the Dynamics of the Presynaptic Nano-Architecture as the basis of rapid information storage in neuronal circuits
  Prof S Schoch, Prof D Dietrich
Applications accepted all year round

Funding Type

PhD Type

A PhD Position in the Dynamics of the Presynaptic Nano-Architecture as the basis of rapid information storage in neuronal circuits is available at the Institute of Neuropathology, University Bonn Medical School, Germany.
  Live-imaging and genetic approaches to explore cross-talk between tissue damage, immune dysfunction and infection within novel animal models of cystic fibrosis
  Dr H Weavers, Prof E Mahenthiralingam, Dr D N Sheppard
Application Deadline: 25 November 2019

Funding Type

PhD Type

Cystic fibrosis (CF) is a genetic disorder driven by mutations in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene.
  Genetic risk factors underlying impaired cognitive flexibility and neural plasticity in psychiatric disorders.
  Prof J Mellor, Dr MC Ashby
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisors. Prof Jack Mellor (Bristol), Jeremy Hall (Cardiff), Dr Michael Ashby (Bristol), Prof Lawrence Wilkinson (Cardiff). Cian O’Donnell (Bristol.
  Exploring the chromatin landscape in early development (WHEELERU20DTP)
  Dr G N Wheeler, Prof A E Munsterberg
Application Deadline: 25 November 2019

Funding Type

PhD Type

The Neural Crest and Placodes are groups of cells found only in vertebrates, specifically in the embryo. They originate at the neural border between the ectoderm and neuroectoderm.
  Do diatoms feel cold? Mechanisms of temperature sensing in temperate and polar diatoms (WHEELERUMBA20ARIES)
  Dr G Wheeler, Prof T Mock, Dr K Helliwell
Application Deadline: 7 January 2020

Funding Type

PhD Type

SCIENTIFIC BACKGROUND. Diatoms are single-celled algae that are able to inhabit diverse marine environments, including habitats that experience significant fluctuations in temperature and salinity, such as estuaries.
  Regulation of food preference and reward by the brain. PhD in Medical School (MRC GW4 BioMed DTP)
  Dr K Ellacott
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Kate Ellacott, Institute of Biomedical and Clinical Sciences, Medical School, University of Exeter. Prof Anthony Pickering, Pharmacology and Physiology, University of Bristol.
  Understanding how altered GABA signalling in the brain’s master clock contributes to circadian rhythm disruption in Alzheimer’s disease. PhD in Medical Studies (MRC GW4 BioMed DTP)
  Dr M Belle
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Mino Belle, Institute of Biomedical and Clinical Science, Medical School, University of Exeter. Dr James Hodge, Faculty of Life Sciences, University of Bristol.
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