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yeast PhD Projects, Programs & Scholarships

We have 53 yeast PhD Projects, Programs & Scholarships

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  Budding yeast as a model for sudden cardiac death
  Dr T Hoefken
Applications accepted all year round

Funding Type

PhD Type

Sudden unexpected cardiac death is responsible for about half of all heart disease deaths. It is an unexpected death caused by a change in heart rhythm.
  The production of alcohols as commodity chemicals/ biofuels using yeast as a vehicle
  Prof M Ashe, Prof C M Grant, Dr J-M Schwartz, Dr J Winterburn
Applications accepted all year round

Funding Type

PhD Type

Crude oil represents probably the most important natural resource to industrial nations. As well as fuel, crude oil is used to produce a host of chemicals that govern modern day life.
  (BBSRC DTP) Tackling the genomic dark matter through system engineering of ncRNAs in yeast
  Prof D Delneri, Prof P Cai
Application Deadline: 31 January 2020

Funding Type

PhD Type

Non-coding RNAs (ncRNAs) are thought as of genomic "dark matter" for which the biological significance has been largely underestimated.
  Targeting yeast epigenetics to combat anti-fungal resistance
  Dr E Hyland, Dr C Law
Application Deadline: 16 December 2019

Funding Type

PhD Type

Project details. One consequence of climate change is the increased incidence of fungal disease, as global temperatures become more aligned with optimal fungal growth conditions.
  Engineering synthetic ribosomal RNAs (rRNAs) in yeast
  Prof P Cai, Prof D Delneri
Applications accepted all year round

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
  Production of Industrial Chemicals for Personal Care and Health Care Using Oleaginous Yeast
  Dr TS Wong
Applications accepted all year round

Funding Type

PhD Type

Many ingredients in the personal care and health care products, for example lipids, are derived from petroleum, animal fat or vegetable oil.
  EASTBIO: Temporal Adaptation to Antifungal Treatment in Pathogenic Fungi
  Dr D Childers, Dr E Wallace
Application Deadline: 5 January 2020

Funding Type

PhD Type

Supervisors. Dr Delma Childers (University of Aberdeen). https://www.abdn.ac.uk/people/delma.childers. Dr Edward Wallace (University of Edinburgh).
  Unravelling mechanisms controlling gene expression noise in S. cerevisiae during rapid adaptive responses and its application to biotechnology.
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr S Granneman, Prof P Swain
Application Deadline: 5 January 2020

Funding Type

PhD Type

Microbes are constantly subjected to changes in their environment and have to rapidly alter their transcriptome to adapt efficiently.
  Structural and biochemical analysis of chromosome segregation in yeast
  Dr D Barford
Application Deadline: 3 December 2019

Funding Type

PhD Type

Our research is focused on understanding the mechanisms and regulation of chromosome segregation in mitosis. During the cell cycle, accurate chromosome segregation ensures that both daughter cells inherit the correct complement of chromosomes.
  Engineering tRNA neochromosomes in yeast
  Prof P Cai, Prof D Delneri
Applications accepted all year round

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
  Defining the sequence requirements for neo-centromere function in the fission yeast Schizosaccharomyces pombe
  Dr W R A Brown, Dr W Wickstead
Applications accepted all year round

Funding Type

PhD Type

Centromeres are the regions of the chromosome necessary for accurate segregation at cell division. They bind a complex set of proteins called the kinetochore which in turn tethers the chromosome to the microtubules of the spindle at cell division.
  The role mRNA-specific translation during chronological aging
  Prof C M Grant, Prof M Ashe, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Biological ageing can be thought of as a progressive decline in the ability of an organism to survive stress and disease. It is a complex process which is influenced by both genetic and environmental factors.
  EASTBIO Unravelling mechanisms controlling gene expression noise in S. cerevisiae during rapid adaptive responses and its application to biotechnology.
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr S Granneman
Application Deadline: 5 January 2020

Funding Type

PhD Type

Microbes are constantly subjected to changes in their environment and have to rapidly alter their transcriptome to adapt efficiently.
  Deciphering the regulation of fission yeast phenotypic heterogeneity by external conditions
  Research Group: Quantitative Gene Expression
  Dr S Marguerat
Application Deadline: 1 December 2019

Funding Type

PhD Type

Phenotypic cell-to-cell variability is a fundamental determinant of microbial fitness that contributes to stress adaptation and drug resistance.
  EASTBIO: Does Rif1 regulate meiotic DNA replication and recombination?
  Dr A Lorenz, Prof A Donaldson, Prof A Marston
Application Deadline: 5 January 2020

Funding Type

PhD Type

Supervisors. Dr Alexander Lorenz (University of Aberdeen). https://homepages.abdn.ac.uk/a.lorenz/pages/index.html. Professor Anne Donaldson (University of Aberdeen).
  Cell polarity regulation in a model eukaryote
  Research Group: Institute of Cell Biology
  Prof K E Sawin
Application Deadline: 5 January 2020

Funding Type

PhD Type

Normal cell architecture and organisation depends on internal and external cues and landmarks. Upon stress, cell organisation can also change in a coordinated way, either to generate changes in shape or to achieve homeostasis at the level of the entire cell.
  EASTBIO: Recurrent evolution of a eukaryotic molecular trait: acquisition of polycistronic RNA processing.
  Dr J Pettitt, Dr B Mueller, Dr M Wenzel, Prof I Stansfield
Application Deadline: 5 January 2020

Funding Type

PhD Type

Supervisors. Dr Jonathan Pettitt (University of Aberdeen). https://www.aberdeenwormlab.org/. Dr Berndt Mueller (University of Aberdeen).
  Natural selection in action: molecular evolution of resistance to anti-microbials (BROWNJ20DTP)
  Prof J Brown
Application Deadline: 25 November 2019

Funding Type

PhD Type

Evolution of resistance to drugs and pesticides is a problem of great practical importance and is also one of the clearest demonstrations of natural selection in action.
  Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells
  Dr M Pool, Prof G D Pavitt
Applications accepted all year round

Funding Type

PhD Type

Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.
  Understanding the role that the RNA helicase UPF1 plays in sorting ribonucleoprotein (RNP) complexes and the mechanism by which this role of UPF1 might reduce cellular stress and cell degeneration.
  Research Group: BBSRC MIBTP
  Dr S Brogna
Application Deadline: 7 January 2020

Funding Type

PhD Type

This project’s specific objective is to study the molecular role(s) that the RNA helicase UPF1 plays in RNA processing. UPF1 is a key player in nonsense-mediated mRNA decay (NMD), it is universally conserved in eukaryotes and is essential to the development of many organisms [1].
  Computer aided design methods for mammalian genome engineering
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr G Stracquadanio, Dr F Menolascina
Application Deadline: 5 January 2020

Funding Type

PhD Type

Computer Aided Design (CAD) software assists engineers in designing systems in-silico, thus reducing the time-to-market of a product and increasing the overall productivity.
  EASTBIO The RNA-bound proteome
  Research Group: Institute of Cell Biology
  Prof D Tollervey
Application Deadline: 5 January 2020

Funding Type

PhD Type

Second Supervisor. Angus Lamond University of Dundee. Functional interactions between RNAs and proteins underpin gene expression and defects in RNA-protein interactions form the basis of numerous human diseases.
  Epigenetic regulation of meiotic genes by the transcription factor Hac1i
  Dr M Schroeder
Applications accepted all year round

Funding Type

PhD Type

A self-funded PhD studentship to investigate how the transcription factor Hac1i achieves epigenetic regulation of early meiotic genes is available in the group of Dr.
  MRC London Institute of Medical Sciences fully funded studentships

Funding Type

PhD Type

We have multiple fully funded studentships available for our 3.5 year PhD programme commencing October 2020. The LMS is a Medical Research Council funded Institute based at the Hammersmith Hospital Campus of Imperial College London.
  Regulation of mitotic and meiotic chromosome function by different cohesin complexes
  Research Group: Meiosis
  Dr E Martinez-Perez
Application Deadline: 1 December 2019

Funding Type

PhD Type

Cohesin, the complex that provides sister chromatid cohesion (SCC) to ensure correct chromosome segregation during cell division, belongs to a family of SMC (structural maintenance of chromosomes) proteins conserved from bacteria to humans (1).
  Multiscale dynamic visualisation framework for industrial mutants design and biological knowledge discovery
  Dr D Zhang
Application Deadline: 30 August 2020

Funding Type

PhD Type

Current industrial bio-production processes exclusively uses yeast and bacteria as the microorganism hosts to synthesise valuable commercial compounds.
  (BBSRC DTP) Optimisation of heteromeric protein complex formation via co-ordinated mRNA localisation
  Prof M Ashe, Dr M Pool, Prof C M Grant
Application Deadline: 31 January 2020

Funding Type

PhD Type

RNA granules play key roles in cells controlling many aspects of mRNA fate. For instance, in response to stress the relocalisation of mRNAs to mRNA processing bodies (P-bodies) and stress granules facilitates the degradation or storage of unwanted or valuable mRNAs, respectively.
  (BBSRC DTP) Understanding mitochondrial protein quality control under normal and stress conditions
  Dr H Lu, Prof C M Grant, Prof S Hubbard
Application Deadline: 31 January 2020

Funding Type

PhD Type

Mitochondria are vitally important organelles within living cells and are often described as their powerhouses, as the primary energy source for all biological activities.
  Partitioning primary and secondary changes of gene expression caused by gene mutations
  Dr D Talavera, Prof G D Pavitt, Dr J-M Schwartz
Applications accepted all year round

Funding Type

PhD Type

Control of gene expression is a complex cell process, which involves balancing both the synthesis and the degradation of RNA and protein so as to establish optimal levels of each protein.
  Proteomic approach to understand mitochondrial quality control under normal and stress conditions
  Dr H Lu, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Defects in protein quality control lead to the accumulation of misfolded and damaged proteins, which play an important role in many diseases (e.g.
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