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Analytical Chemistry (screening) PhD Projects, Programs & Scholarships

We have 11 Analytical Chemistry (screening) PhD Projects, Programs & Scholarships

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  EPSRC CASE PhD studentship: Novel high-throughput approaches for the rapid analysis of target engagement by mass spectrometry (collaboration with Medicines Discovery Catapult)
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof F. Sobott, Dr J.R. Ault
Application Deadline: 28 February 2020

Funding Type

PhD Type

The ability to provide fast and efficient readouts for drug engagement with targets (proteins and oligonucleotides) is a key driving technology in the biopharma pipeline, e.g.
  Chemo-enzymatic Synthesis and Potential Applications of Novel Heterocyclic Alkaloids
  Dr H Deng, Dr L Trembleau
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  Biosensors for Forensic Analysis - 4 Year PHD Studentship
  Research Group: School of Population Health & Environmental Sciences
  Dr N Frascione, Dr J Gooch
Application Deadline: 14 February 2020

Funding Type

PhD Type

The Forensic Biochemistry group within the School of Population Health & Environmental Sciences is seeking an exceptional and highly motivated early career researcher with a strong background in analytical science, forensic science or biochemistry to undertake a fully funded PhD studentship in the development of biosensors for the detection and identification of body fluids.
  Diffusion Ordered Spectroscopy NMR for the Rapid Identification of Medicinal Plants
  Dr JM Peron, Dr A Le Gresley
Applications accepted all year round

Funding Type

PhD Type

Diffusion Ordered Spectroscopy (DOSY) is a nuclear magnetic resonance (NMR) technique that is used to analyse mixtures.[1–3] Put simply, NMR signals that overlap in 1D NMR spectra are separated in 2D DOSY spectra according to molecular size and those that belong to the same component align as they are governed by the same diffusion coefficient.
  (BBSRC DTP CASE) Discovery and Engineering of Expanded Halogenases for Late Stage Enzymatic Functionalisation
  Prof J Micklefield, Prof P Barran
Application Deadline: 31 January 2020

Funding Type

PhD Type

The project aims to discover and engineer novel enzymes (biocatalysts) that can affect regioselective halogenation of complex molecules enabling more efficient and environmentally sustainable production of pharmaceuticals which are urgently required to combat disease.
  (BBSRC DTP CASE) Exploitation of P450 BM3 variants for production of valuable drug metabolites
  Prof A Munro, Prof D Leys
Application Deadline: 31 January 2020

Funding Type

PhD Type

The US Food and Drug Administration (FDA) have recommended that human drug metabolites (as well as their parent drugs) should be subject to testing for safety/toxicity.
  (BBSRC DTP) Discovery, development and application of novel amine and imine biocatalysts for the synthesis of natural products, their analogues and other privileged motifs
  Dr R Whitehead, Prof N Turner, Prof P Barran
Application Deadline: 31 January 2020

Funding Type

PhD Type

This is a cross-disciplinary project, which combines the complementary research expertise of Professor Nick Turner (biocatalysis), Professor Perdita Barran (mass spectrometry) and Dr Roger Whitehead (organic synthesis/biological chemistry).
  Understanding regulation of gene expression during development via an integrated computational analysis of ‘omics data
  Prof S Hubbard, Prof S Griffiths-Jones, Dr M Baron
Applications accepted all year round

Funding Type

PhD Type

Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome.
  Targeting ubiquitin ligases with small molecules to develop new therapeutics (CHANTRYAU20SCIO)
  Dr A Chantry, Dr A M Hemmings
Application Deadline: 30 January 2020

Funding Type

PhD Type

Ubiquitination (the addition of ubiquitin to specific proteins) is a key regulatory mechanism for cellular processes such as protein turnover via the ubiquitin-proteasome system (UPS), trafficking, autophagy, subcellular localisation, transcription and DNA repair.
  Understanding and dissecting microbial communities with Raman spectroscopy
  Prof R Goodacre
Applications accepted all year round

Funding Type

PhD Type

We have shown that it is possible to label bacteria with heavy isotopes of carbon (13C) and nitrogen (15N) and this incorporation within cellular biomass of heavy isotopes has led to significant shifts in certain vibrational modes from amino acids and nucleic acids that can be readily detected with Raman spectroscopy.
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