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Analytical Chemistry (structural biology) PhD Projects, Programs & Scholarships

We have 18 Analytical Chemistry (structural biology) PhD Projects, Programs & Scholarships

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  Developing H/D-exchange mass spectrometry for native membrane protein structural biology
  Dr E Reading
Application Deadline: 12 April 2020

Funding Type

PhD Type

Supervisors. Dr. Eamonn Reading (Primary supervisor – KCL), Mr. Malcolm Anderson (Industrial supervisor - Waters Corporation), Prof.
  Establishing NMR chemical shifts as reliable reporters of atomic charge distributions in enzymes
  Prof J Waltho, Prof P Popelier
Applications accepted all year round

Funding Type

PhD Type

Enzymes are not only central to life but also to the growing need to harness elements of the natural world to the benefit of mankind.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
  EPSRC CASE PhD studentship: Novel high-throughput approaches for the rapid analysis of target engagement by mass spectrometry (collaboration with Medicines Discovery Catapult)
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof F. Sobott, Dr J.R. Ault
Application Deadline: 28 February 2020

Funding Type

PhD Type

The ability to provide fast and efficient readouts for drug engagement with targets (proteins and oligonucleotides) is a key driving technology in the biopharma pipeline, e.g.
  Molecular analysis of the dynamic sulfotyrosine proteome
  Prof C E Eyers, Prof P Eyers, Dr A R Jones
Applications accepted all year round

Funding Type

PhD Type

The survival of an organism depends upon the ability of different cell types to communicate with each other by assembling the correct complexes of proteins at the correct time in the correct place.
  Multi-omics investigations for enhanced understanding of NF-κB mediated drug resistance
  Prof R Goodacre, Prof N Perkins, Prof C E Eyers, Dr A R Jones
Application Deadline: 1 June 2020

Funding Type

PhD Type

We have an established system that can be used to investigate the role of NF-κB signalling in the cancer cell response to DNA replication stress and have generated cell lines which are resistant to treatment with a highly selective and specific CHK1 inhibitor (CCT244747).
  Development of metabolomics for understanding AMR in mixed infections
  Prof R Goodacre
Applications accepted all year round

Funding Type

PhD Type

Without correct antibiotic stewardship we could be cast back to a pre-infective era where we have run out of antibiotics to treat life-threatening infections.
  Understanding and dissecting microbial communities with Raman spectroscopy
  Prof R Goodacre
Applications accepted all year round

Funding Type

PhD Type

We have shown that it is possible to label bacteria with heavy isotopes of carbon (13C) and nitrogen (15N) and this incorporation within cellular biomass of heavy isotopes has led to significant shifts in certain vibrational modes from amino acids and nucleic acids that can be readily detected with Raman spectroscopy.
  Differential ion mobility spectrometry and mass spectrometry for proteomics
  Prof H J Cooper
Applications accepted all year round

Funding Type

PhD Type

Research in our laboratory focuses on the application of state-of-the-art mass spectrometry techniques to the global analysis of peptides and proteins.
  Mathematical Virology: A New Mathematical Approach to Viral Evolution Grounded in Experiment
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

Mathematical modelling of natural phenomena has the potential to be predictive but requires direct verification by experiment. Such models can then be very powerful indicators of our understanding and they permit in silico simulations of situations that are difficult to test experimentally.
  Mass spectrometry analysis of human tissue to characterise cleavage events resulting in amyloid deposition associated with aortic aneurysm and dissection
  Dr J Madine, Prof C E Eyers
Applications accepted all year round

Funding Type

PhD Type

The most common form of localised amyloid occurs in the aorta (aortic medial amyloid; AMA) and is estimated to occur in 97% of Caucasian people over 50.
  Carbohydrate analysis for biomedical applications.
  Dr S Allman
Applications accepted all year round

Funding Type

PhD Type

Changes in the patterns of carbohydrates produced by the cell can provide insights into disease states, revealing perturbations and differences in cellular metabolic processes.
  Cationic antimicrobial peptides as anticancer agents
  Dr R Green, Prof R A Frazier
Applications accepted all year round

Funding Type

PhD Type

Cationic peptides are widespread in nature where they play a key role in host defense within plants and animals. The mechanism by which these peptides interact with cell membranes potentially leads to these being less prone to antimicrobial resistance than conventional antibiotics.
  Integrating mass spectrometry metabolomics, imaging and bioinformatics to develop physiology-based kinetic models for chemical safety science
  Prof M Viant, Dr B Campos, Dr C Rivetti, Dr I Sorrell
Application Deadline: 1 April 2020

Funding Type

PhD Type

**If you are interested in this studentship, it is vital to contact Professor Mark Viant prior to applying with a copy of your CV.
  Design and synthesis of novel, targeted, anti-cancer agents
  Prof H Osborn, Dr F Greco
Applications accepted all year round

Funding Type

PhD Type

One of the major problems of cancer chemotherapy is that the drugs used have poor selectivities for cancer cells and cause damage to normal cells and organs.
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