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University of Manchester Applied Mathematics PhD Projects, Programs & Scholarships

We have 46 University of Manchester Applied Mathematics PhD Projects, Programs & Scholarships

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Showing 1 to 10 of 46
  (BBSRC DTP) Integrative statistical inference methods for eukaryotic gene regulation with applications to embryonic stem cell differentiation
  Prof M Rattray, Dr I Iqbal, Prof A Sharrocks
Application Deadline: 31 January 2019
Embryonic stem cells (ESCs) can differentiate into different cell types through intermediary cell states and deeper understanding of the regulatory control underlying these differentiation stages is a very important topic in the study of mammalian development (Yang et al., 2014).
  (BBSRC DTP) Microbial population diversity as a driver of antibiotic resistance evolution
  Dr D Gifford, Dr C Knight, Dr T Gilman
Application Deadline: 31 January 2019
Classically, microbial evolution has been thought to progress via rapid sweeps of beneficial mutations that quickly fix within populations—the so-called ‘strong selection, weak mutation’ model.
  (BBSRC DTP) Partitioning primary and secondary changes of gene expression caused by gene mutations
  Dr D Talavera, Prof G D Pavitt, Dr J-M Schwartz
Application Deadline: 31 January 2019
Control of gene expression is a complex cell process, which involves balancing both the synthesis and the degradation of RNA and protein so as to establish optimal levels of each protein.
  (BBSRC DTP) Using multilayer networks to organise and model cellular function
  Dr J-M Schwartz, Dr G Nenadic, Prof D Robertson
Application Deadline: 31 January 2019
Most biological functions arise from complex sets of physical interactions between proteins and various regulatory pathways, which are extremely difficult to reconstruct, represent and analyse manually.
  Analysis of the role of microRNAs in the regulation of NF-kappaB dynamics and function
  Prof M White, Dr A P Gilmore
Applications accepted all year round
NF-κB is one of most important cell signalling systems in the body and controls inflammation and cell fate. NF-κB signalling involves complex dynamics involving oscillations of the NF-κB complex between the nucleus and cytoplasm in activated cells.
  Effective models for function-structure relationship in complex biological media
  Dr I Chernyaysky, Prof O Jensen, Dr E Johnstone
Applications accepted all year round
A complex multiscale relationship between the structure and function is common in many human organs (such as the lung, liver and placenta), and many diseases are associated with an imbalance in the relationship.
  Exploring the influence of treatment on CD4+ T-cell sub-populations in patients receiving biologic drugs for their inflammatory arthritis
  Prof A Barton, Dr D Plant, Dr S Viatte
Applications accepted all year round
Background. Tumour necrosis factor inhibitor (TNFi) therapy is ineffective for approximately 20% of rheumatoid arthritis (RA) patients and there is currently no way to predict which patients will not benefit.
  Multi-scale network reconstruction and modelling of phage – bacteria interactions
  Dr J-M Schwartz, Prof S Lovell
Applications accepted all year round
Bacteriophages are viruses that infect bacteria. They are seen as a promising alternative to antibiotics, particularly as multi-resistant bacterial strains are becoming more widespread and could one day render existing antibiotic therapies ineffective.
  Towards more sustainable use of phosphorus in UK grasslands considering soil-plant interactions
  Dr V Niasar, Prof D Johnson, Dr S Lee
Applications accepted all year round
This ambitious project will lead to a major shift in how soil phosphorus (P), is managed in UK grasslands.
  Gas-Solid Reactors for Sustainable Processes in the Chemical Industry
  Research Group: Process Development and Integration
  Dr V Spallina, Prof C Hardacre
Application Deadline: 30 December 2018
Advanced energy and chemical plants require new reactors and processes designed to combine high efficiency, attractive economics and reduced pollutant emissions.
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