We focus on developing general platforms for the purification of antibodies, their fragments & proteins in general without the need for any chromatographic steps, specific ligands, membranes or polymers (resins). . Read more
Bacterial antibiotic resistance is a global public health emergency that already causes 1.3m deaths annually. The problem is exacerbated by continuing failure to develop new antibiotics, especially drugs with novel modes of action that evade resistance to agents in current use. Read more
Background. Tackling infectious diseases represents one of the major global societal challenges of the 21st century. The discovery of antibiotics led to a new era of infection medicine and is widely regarded as one of the most significant medical advancements in history. Read more
Urinary tract infection (UTI) is a very common presentation in primary care, and the most common infection leading to microbiological examination and antibiotic treatment. Read more
As part of the National Institute for Health Research funded, Leeds Biomedical Research Centre (BRC), one PhD scholarship is available for UK fee rated applicants only. Read more
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 21 studentships for entry in September 2025. Read more
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 21 studentships for entry in September 2025. Read more
Our ability to fight infections relies not on the capacity of our professional immune system to defend our body but also on the skills of individual cells to defend themselves. Read more
TRIM21 is the cytosolic E3 ligase and antibody receptor responsible for intracellular antibody immunity. Unlike other ubiquitin ligases, TRIM21 doesn’t have a defined substrate but is directed towards its targets by antibodies. Read more
Project description. Primary supervisor - Dr Stephanie Schüller. Crohn’s Disease (CD) is a chronic inflammatory bowel disorder affecting > 120,000 people in the UK. Read more
This project is devoted to an AI-based prediction of bacteria growth and its control by antibiotics. In synthetic biology, an improved understanding of bacterial regulatory circuits is required to develop complex biological systems with functionalities beyond existing in nature [1, 2]. Read more
The last 80 years has witnessed the rapid emergence of antibiotic resistant pathogens driven by the widespread reliance on antibiotics to control infectious disease in clinical and veterinary medicine. Read more
In this age of increasing antimicrobial resistance, bacterial infections remain a major global health burden. During infection, bacterial pathogens deliver virulence proteins into the host cells. Read more
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