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We have 21 Chemistry PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Belfast
Chemistry PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Belfast
We have 21 Chemistry PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Belfast
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Safer, scalable, and modifiable polymer-based lipid nanocapsules for drug delivery
Lipid nanocapsules (LNCs) are very interesting nanoformulations as they can be made by phase inversion technique (PIT), a scalable method with predictable particle size at the beginning of the preparation process. Read more
Structure-based design of allosteric modulators for G protein-coupled receptors using molecular modelling and pharmacology experiments
Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more
QUADRAT DTP: Is nibbled, riddled and rotten good for health? Biodiverse stimulation of antiparasitic chemical production by plants and fungi
About the Project. Control of parasitic infections in grazing livestock is under severe strain from drug resistance and climate change, and new approaches are urgently needed. Read more
Dissecting mechanism of drug responses to novel anti-cancer therapies
Repurposing drug screens with compounds that have already gained FDA approval can accelerate the identification of new therapies to treat an illness and in the cancer setting extend life or provide compassionate care. Read more
Development of Nanomaterials for Targeting the Bacteria–Host Interface in Cystic Fibrosis Airways
The attachment of Pseudomonas aeruginosa (PA) to the airway mucus in the lungs of people with cystic fibrosis (CF) represents an important step in airway colonization and the subsequent development of lung infection. Read more
Development of carbohydrate-functionalised materials for detection and prevention of medical device-associated infections
Antibiotic-resistant bacteria are a growing problem in the 21st century, causing longer and more serious infections, and resulting in poor outcomes for vulnerable patients. Read more
Chemical glycoengineering of therapeutic antibodies
Glycosylation is the most common posttranslational protein modification. Recombinant therapeutic glycoproteins (RTGs) such as monoclonal antibodies (mAbs) are decorated with complex glycans that determine not only their efficacy but also other critical parameters such as in vivo half-life, stability and antigenicity. Read more
Bio-inspired liquid-like coatings for medical devices to combat biofilms and associated infections
Biofilms are microbial cells embedded within a self-secreted extracellular polymeric substance matrix, which are central to some of the most urgent global challenges across diverse fields of application, from medicine to industry and exert considerable economic and social impact. Read more
High throughput screening models for intracellular delivery of antimicrobial nanotherapeutics
Fungal and bacterial infections contribute to over 7 million deaths yearly, affecting over 300 million people globally (. GAFFI. ). Read more
Mechanochemical synthesis of polymer-drug conjugates via reactive extrusion
Polymer–drug conjugate (PDCs) therapeutics are pharmacologically active macromolecular constructs comprising at least one therapeutic agent covalently bound to a polymeric carrier. Read more
Microneedle delivery systems for next-generation antibody therapeutics
Microneedle arrays are minimally-invasive devices that painlessly, and without drawing blood, penetrate the skin’s stratum corneum barrier. Read more
Polymer-engineering nanocages for protein delivery
Protein therapeutics are a fast-acting and potent class of medicine with remarkable success in the treatment of several relevant disorders. Read more
Self-regulating, self-cleaning biomaterials
A major problem associated with medical devices is infection. With infection rates of approaching 100% in some devices, ways to prevent formation of bacterial biofilm on medical device surfaces are urgently required. Read more
Enzyme-responsive peptide hydrogel as in situ forming long-acting drug delivery implants
One of the key issues in the treatment and prevention of disease is that patients struggle to adhere to the complex dosage regimens of therapies, which often require multiple dosing at very specific times each day. Read more
Digital design and advanced processing technologies for antimicrobial nanotherapeutics
Fungal and bacterial infections contribute to over 7 million deaths yearly, affecting over 300 million people globally (GAFFI). Read more
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