Community medical and nursing teams are increasingly called upon to deliver palliative and end-of-life care to terminally ill people living in their own homes and in long-term care settings such as nursing homes. Read more
Implantable medical devices are commonplace in modern medicine (e.g. joint replacements, stents, artificial heart valves, etc.), and are of ever increasing interest in the field of regenerative medicine. Read more
Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more
The attachment of Pseudomonas aeruginosa (PA) to the airway mucus in the lungs of people with cystic fibrosis (CF) represents an important step in airway colonization and the subsequent development of lung infection. Read more
Biofilms are microbial cells embedded within a self-secreted extracellular polymeric substance matrix, which are central to some of the most urgent global challenges across diverse fields of application, from medicine to industry and exert considerable economic and social impact. Read more
Poor drug solubility presents a major challenge in drug product development of oral solid dosage (OSD) forms. However, many new development compounds exhibit poor solubility and only a few of them reach market approval. Read more
Progress in drug design has led to the development of new molecules. However, the limited ability to selectively deliver these molecules at well-defined dosing regimens remains a significant challenge. Read more
According to WHO, cancer is the second leading cause of death worldwide, with nearly 1 in 6 deaths been due to cancer. The principal modes of cancer management are surgery, radiotherapy, chemotherapy and pharmaceutical agents. Read more
Breast Cancer (BC) is the most common cancer in the UK, accounting for 15% of new cancer cases. There is a significant unmet clinical need to understand why some cancers do not respond to treatment and what drives metastasis. Read more
Many infections and disease states are closely linked to associated microbiomes, either of the patient themselves or the surrounding clinical environment. Read more
USP17 is over-expressed in a range of primary tumours (NSCLC, breast, colorectal, cervical, ovarian, osteosarcoma) and its depletion blocks the growth, and migration, of cells from all of these cancer types. Read more
Medicines management is a complex process for people living with dementia (PLWD), who often have other comorbidities and are frequently prescribed multiple regular medicines. Read more
Polymer–drug conjugate (PDCs) therapeutics are pharmacologically active macromolecular constructs comprising at least one therapeutic agent covalently bound to a polymeric carrier. Read more
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