Research Group:
Wellcome-Wolfson Institute for Experimental Medicine
Acute Respiratory Distress Syndrome (ARDS) is a severe condition characterized by acute inflammation and diffuse alveolar damage, leading to respiratory failure. Read more
Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more
The attachment of Pseudomonas aeruginosa (PA) to the airway mucus in the lungs of people with cystic fibrosis (CF) represents an important step in airway colonization and the subsequent development of lung infection. Read more
Research Group:
Wellcome-Wolfson Institute for Experimental Medicine
Join a distinguished translational experimental group that spans from lab work to delivery of specialist asthma clinical care, seeking to understand variation in airways immunity and how this results in varied responses to current asthma therapies. Read more
Research Group:
Wellcome-Wolfson Institute for Experimental Medicine
Acute Respiratory Distress Syndrome (ARDS) is a common condition in critically ill patients requiring mechanical ventilation, and is often found in association with sepsis and other systemic illnesses. ARDS is associated with a high mortality, and there are no effective pharmacological interventions. . Read more
The prices of new pharmaceuticals have increased by orders of magnitude over the last two decades, and emerging gene therapies are expected to be priced a magnitude higher than the cellular therapies such as monoclonal antibodies. Read more
Research Group:
Wellcome-Wolfson Institute for Experimental Medicine
Detecting bacterial infection in children is very challenging, particularly in previously well children presenting to the Emergency department (ED) with fever as well as in children with chronic illnesses, such as those with cystic fibrosis (CF). Read more
Research Group:
The Patrick G Johnston Centre for Cancer Research
Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are clonal haematological malignancies that can disrupt normal haematopoiesis of multiple myeloid lineages. Read more
Research Group:
Wellcome-Wolfson Institute for Experimental Medicine
This project will use plasma samples of children with congenital heart disease to evaluate the role of novel and established cardiac biomarkers in identifying and monitoring paediatric heart failure. Read more
Cochlear implants are surgically implanted neuroprostheses designed to produce useful hearing sensations to persons with severe-to-profound sensorineural hearing loss by electrically stimulating the auditory nerve in the inner ear (or cochlea). Read more
One of the most challenging issues that the pharmaceutical industry face is poor aqueous solubility of drugs. 90% of candidate molecules within the discovery pipelines face solubility issues, posing significant hurdles to their clinical translation. Read more
Progress in drug design has led to the development of new peptides, proteins, and drug molecules. However, the limited ability to deliver selectively these molecules at well-defined dosing regimens and without invoking drug-resistance remains a significant challenge. Read more
The World Health Organisation (WHO) identifies antimicrobial resistance (AMR) as one of the top 10 global threats to human health (http://www.who.int/). Read more
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