Progress in drug design has led to the development of new peptides, proteins, and drug molecules. However, the limited ability to deliver selectively these molecules at well-defined dosing regimens and without invoking drug-resistance remains a significant challenge. Read more
With the increasing prevalence of debilitating eye diseases such as age-related macular degeneration, glaucoma, and dry-eye syndromes, there is a pressing need for the development of novel therapeutic strategies. Read more
Minimally invasive microneedles (MNs) offer unique opportunities to address current challenges in the effective management of ocular disorders, such as age-related macular degeneration and diabetic retinopathy. Read more
Self-assembling peptide-based hydrogels (SAPH) are composed of short peptide sequences, typically consisting of 5 to 20 amino acids, which undergo spontaneous self-assembly into three-dimensional networks under physiological conditions. Read more
According to WHO, cancer is the second leading cause of death worldwide, with nearly 1 in 6 deaths been due to cancer. The principal modes of cancer management are surgery, radiotherapy, chemotherapy and pharmaceutical agents. Read more
Current clinical therapies often rely on intermittent drug administration, such as frequent oral tablets or injections, as seen in diabetes management. Read more
Ocular drug delivery presents one of the greatest challenges in pharmaceutical science, largely due to the eye’s unique anatomy, which limits drug permeation to the intended site of action. Read more
The use of medications by older adults is acknowledged to be the most common form of medical intervention for many acute and chronic conditions and prescribing amongst the older population (those aged 65 years and over) continues to increase due to increasing multimorbidity. Read more
Three drug products are now available to prevent HIV prevention: . Truvada®/ Descovy®—daily oral pills containing the antiretroviral drugs emtricitabine and tenofovir . Read more
Skin is one of the most organs of the human body exposed to irritants, pollutants and xenobiotics from the environment. Skin health and safety is based on skins’ endogenous antioxidants reserves. Read more
The aim of this project is to engineer brain-targeted nanoparticles to efficiently deliver novel therapeutic agents for the treatment of neurodegenerative diseases (e.g., Parkinson’s and Alzheimer’s Disease), which currently affect 15% globally and are increasing due to aging populations. Read more
Chimeric antigen receptor (CAR)-T therapies have demonstrated remarkable treatment outcomes and several CAR-T therapies now approved for treatment of haematological malignancies. Read more
Catheter-associated urinary tract infections (CAUTIs) are among the most common hospital-acquired infections worldwide threatening over 150 million people annually, imposing substantial burdens on the health system. Read more
Diabetic foot ulcers (DFU) present a significant clinical challenge, affecting millions worldwide and often leading to severe complications, including infection and amputation. Read more
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