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We have 17 Biochemistry (cell migration) PhD Projects, Programmes & Scholarships

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Biochemistry (cell migration) PhD Projects, Programmes & Scholarships

We have 17 Biochemistry (cell migration) PhD Projects, Programmes & Scholarships

Is there a Role for Activated Akt in Palatogenesis?

Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more

Cancer biology: identification of new treatment options for EML4-ALK driven lung cancer through understanding mechanisms of cell division and migration.

Lung cancer is the largest cause of cancer-related deaths in the UK and worldwide. While little progress has been made in long-term survival rates, we now have a good understanding of the genetic drivers raising the prospect of earlier diagnosis and more effective treatments. Read more

Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

How does myosin 10 contribute to filopodia formation and stability?

How do cells make filopodia? Filopodia are thin protrusions that act as pathfinders in cell migration, helping cells to sense where to go, and pulling cells through the extracellular matrix, especially important in driving cancer cell metastasis. Read more

SLS 3: Investigating the anti-inflammatory effects of artemisinin compounds on macrophages under systemic inflammatory conditions

Artemisinin compounds are safe and effective antimalarials. Recent evidence in our lab has shown these compounds also exert a potent anti-inflammatory effect by inhibiting neutrophil migration and the release of cytokines, chemokines and neutrophil extracellular traps. Read more

Regulation of CaaX protein processing

USP17 is over-expressed in a range of primary tumours including NSCLC, breast, colorectal, cervical, ovarian and osteosarcoma and its depletion has been shown to block the growth of cells from all these cancer types, as well as the migration of a range of cancer cells (NSCLC, breast, ovarian, osteosarcoma).    . Read more

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