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We have 153 Biochemistry (english) PhD Projects, Programmes & Scholarships

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Biochemistry (english) PhD Projects, Programmes & Scholarships

We have 153 Biochemistry (english) PhD Projects, Programmes & Scholarships

Protein engineering enzymes for Industry

Project Overview. We are interested in key features of the protein sequence - structure - function relationship, and how this information can be translated to health. Read more

Using CRISPR in iPS cells to modify platelet function

Project Overview. Platelets are the small cells in the blood whose job it is to prevent bleeding. Under normal conditions, when they encounter a damaged blood vessel they become activated and form a thrombus. Read more

PhD in Chemistry: Microwave assisted heterogeneous catalysis

The PhD will be based within the Cardiff Catalysis Institute (CCI) (www.cf.ac.uk/cci) which is one of the leading centres for catalyst research focussed on improving the understanding of catalysis, developing new catalytic processes with industry and promoting the use of catalysis as a sustainable 21st century technology. Read more

Staphylococcus aureus colonisation and pathogenicity

Project Overview.  . Staphylococcus aureus is a versatile and adaptable pathogen of humans and animals. Of serious medical and economic importance, infections can range from mild skin issues like boils and impetigo to more serious conditions like pneumonia and bloodstream infections. Read more

The effect of early-life stress on cardiac function in later life

Stressful experiences in early childhood can increase the risk of cardiovascular disease (CVD) in later life. How early-life stress (ELS) influences susceptibility to CVD onset remains largely unknown. Read more

Unravelling the Intricacies of Stress Hormone Regulation

Project Overview. The proopiomelanocortin (POMC) pathway is a crucial signaling cascade involved in regulating various physiological processes, including our response to stress, metabolism, immune function, and pigmentation. Read more

Investigating Neuropeptide Signalling From Synthesis to Survival

Neuropeptides, comprising of short amino acid chains, are potent bioactive molecules with extensive neuromodulatory functions and are predominantly expressed within the central nervous system. Read more

Targeting the extracellular matrix remodelling for the treatment of obesity-associated cardio-renal dysfunction

Obesity is a risk factor for many chronic metabolic diseases including heart failure and chronic kidney disease. Our lab demonstrated a tight association between increased deposition of extracellular matrix components (e.g. Read more

Targeting Ras palmitoylation for the treatment of cancer

Lay summary. Proteins can be thought of as molecular machines that carry out work within cells. Protein activity can be regulated through the reversible attachment of certain chemical groups to specific amino acids within proteins. Read more

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

Investigating lysosomal (dys)function in ageing and neurodegeneration

Project Overview. Ageing is associated with a decline in the functions of an organism (López-Otín, C. et al. Cell, 2023) and correlates with an increased risk of developing diseases in the later life (Niccoli, T. Read more

Developing novel targeted therapeutic approaches through induced-proximity of proteins

Protein post-translational code is at the heart of protein function and signal transduction in cells. Enzymes catalyse the addition or removal of post-translational modifications (PTM), such as phosphorylation, methylation, acetylation, and ubiquitylation, on proteins. Read more

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